BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

435 related articles for article (PubMed ID: 29357810)

  • 1. Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells.
    Ogasawara A; Kato N; Torimoto N; Aohara F; Ohashi R; Yamada Y; Taniguchi H
    Drug Metab Lett; 2018; 12(1):14-23. PubMed ID: 29357810
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
    Rhodes SP; Otten JN; Hingorani GP; Hartley DP; Franklin RB
    J Pharmacol Toxicol Methods; 2011; 63(3):223-6. PubMed ID: 21111054
    [TBL] [Abstract][Full Text] [Related]  

  • 3. New Screening Criteria Setting on Evaluation of Cytochrome P450 Induction Using HepaRG Cells with Multiplex Branched DNA Technologies in Early Drug Discovery.
    Ogasawara A; Torimoto N; Tsuda N; Aohara F; Ohashi R; Yamada Y; Taniguchi H
    Drug Metab Lett; 2016; 10(3):152-160. PubMed ID: 27550199
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays.
    Murayama N; Usui T; Slawny N; Chesné C; Yamazaki H
    Drug Metab Lett; 2015; 9(1):3-7. PubMed ID: 25600204
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents.
    Uehara S; Uno Y; Suzuki T; Inoue T; Utoh M; Sasaki E; Yamazaki H
    Drug Metab Lett; 2017; 10(4):244-253. PubMed ID: 27842484
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.
    Kenny JR; Chen L; McGinnity DF; Grime K; Shakesheff KM; Thomson B; Riley R
    Xenobiotica; 2008 Dec; 38(12):1500-17. PubMed ID: 18989830
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells.
    Sugiyama I; Murayama N; Kuroki A; Kota J; Iwano S; Yamazaki H; Hirota T
    Xenobiotica; 2016 Sep; 46(9):765-74. PubMed ID: 26711482
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective Suppression of CYP3A4 mRNA and Enzyme Activity by Epidermal Growth Factor in Plated Human Hepatocytes.
    Zhang JG; Wang D; Ho T; Clark RJ; Stresser DM
    Drug Metab Lett; 2017; 11(2):119-127. PubMed ID: 29189189
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.
    Bachmann F; Duthaler U; Meyer Zu Schwabedissen HE; Puchkov M; Huwyler J; Haschke M; Krähenbühl S
    Clin Pharmacol Ther; 2021 Jun; 109(6):1505-1516. PubMed ID: 33336382
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
    Preiss LC; Liu R; Hewitt P; Thompson D; Georgi K; Badolo L; Lauschke VM; Petersson C
    Drug Metab Dispos; 2021 Aug; 49(8):668-678. PubMed ID: 34035124
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells.
    Anthérieu S; Chesné C; Li R; Camus S; Lahoz A; Picazo L; Turpeinen M; Tolonen A; Uusitalo J; Guguen-Guillouzo C; Guillouzo A
    Drug Metab Dispos; 2010 Mar; 38(3):516-25. PubMed ID: 20019244
    [TBL] [Abstract][Full Text] [Related]  

  • 12. An 'all-inclusive' 96-well cytochrome P450 induction method: measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes.
    Halladay JS; Wong S; Khojasteh SC; Grepper S
    J Pharmacol Toxicol Methods; 2012; 66(3):270-5. PubMed ID: 22809809
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin.
    Zhang JG; Ho T; Callendrello AL; Crespi CL; Stresser DM
    Drug Metab Lett; 2010 Dec; 4(4):185-94. PubMed ID: 20583967
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
    Madan A; Graham RA; Carroll KM; Mudra DR; Burton LA; Krueger LA; Downey AD; Czerwinski M; Forster J; Ribadeneira MD; Gan LS; LeCluyse EL; Zech K; Robertson P; Koch P; Antonian L; Wagner G; Yu L; Parkinson A
    Drug Metab Dispos; 2003 Apr; 31(4):421-31. PubMed ID: 12642468
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions.
    Abadie-Viollon C; Martin H; Blanchard N; Pekthong D; Bachellier P; Mantion G; Heyd B; Schuler F; Coassolo P; Alexandre E; Richert L
    Toxicol In Vitro; 2010 Feb; 24(1):346-56. PubMed ID: 19497360
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans.
    Kanebratt KP; Andersson TB
    Drug Metab Dispos; 2008 Jan; 36(1):137-45. PubMed ID: 17954527
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rapid determination of rat hepatocyte mRNA induction potential using oligonucleotide probes for CYP1A1, 1A2, 3A and 4A1.
    Surry DD; Meneses-Lorente G; Heavens R; Jack A; Evans DC
    Xenobiotica; 2000 May; 30(5):441-56. PubMed ID: 10875679
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.
    Runge D; Köhler C; Kostrubsky VE; Jäger D; Lehmann T; Runge DM; May U; Stolz DB; Strom SC; Fleig WE; Michalopoulos GK
    Biochem Biophys Res Commun; 2000 Jun; 273(1):333-41. PubMed ID: 10873607
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics.
    Choi JM; Oh SJ; Lee SY; Im JH; Oh JM; Ryu CS; Kwak HC; Lee JY; Kang KW; Kim SK
    Arch Pharm Res; 2015; 38(5):691-704. PubMed ID: 25336106
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation.
    Uno Y; Uehara S; Ushirozako G; Murayama N; Suemizu H; Yamazaki H
    Xenobiotica; 2023 Dec; 53(6-7):465-473. PubMed ID: 37800661
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.