BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 29414024)

  • 1. Metabolism of flavonolignans in human hepatocytes.
    Vrba J; Papoušková B; Roubalová L; Zatloukalová M; Biedermann D; Křen V; Valentová K; Ulrichová J; Vacek J
    J Pharm Biomed Anal; 2018 Apr; 152():94-101. PubMed ID: 29414024
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans.
    Vrba J; Papoušková B; Lněničková K; Kosina P; Křen V; Ulrichová J
    J Pharm Biomed Anal; 2020 Jan; 178():112972. PubMed ID: 31727359
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin.
    Vrba J; Papoušková B; Kosina P; Lněničková K; Valentová K; Ulrichová J
    Metabolites; 2020 Aug; 10(8):. PubMed ID: 32806559
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota.
    Valentová K; Havlík J; Kosina P; Papoušková B; Jaimes JD; Káňová K; Petrásková L; Ulrichová J; Křen V
    Metabolites; 2020 Jan; 10(1):. PubMed ID: 31936497
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.
    Albassam AA; Frye RF; Markowitz JS
    Chem Biol Interact; 2017 Jun; 271():24-29. PubMed ID: 28457856
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The study of flavonolignan association patterns in fruits of diverging Silybum marianum (L.) Gaertn. chemotypes provides new insights into the silymarin biosynthetic pathway.
    Martinelli T; Whittaker A; Benedettelli S; Carboni A; Andrzejewska J
    Phytochemistry; 2017 Dec; 144():9-18. PubMed ID: 28863306
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hepatic biotransformation of non-psychotropic phytocannabinoids and activity screening on cytochromes P450 and UDP-glucuronosyltransferases.
    Havlasek J; Vrba J; Zatloukalova M; Papouskova B; Modriansky M; Storch J; Vacek J
    Toxicol Appl Pharmacol; 2023 Oct; 476():116654. PubMed ID: 37574147
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9, 2C19, 2D6, and 3A4) enzymes.
    Faisal Z; Mohos V; Fliszár-Nyúl E; Valentová K; Káňová K; Lemli B; Kunsági-Máté S; Poór M
    Biomed Pharmacother; 2021 Jun; 138():111459. PubMed ID: 33706132
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.
    Wen Z; Dumas TE; Schrieber SJ; Hawke RL; Fried MW; Smith PC
    Drug Metab Dispos; 2008 Jan; 36(1):65-72. PubMed ID: 17913795
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metabolism of palmatine by human hepatocytes and recombinant cytochromes P450.
    Vrba J; Papouskova B; Pyszkova M; Zatloukalova M; Lemr K; Ulrichova J; Vacek J
    J Pharm Biomed Anal; 2015 Jan; 102():193-8. PubMed ID: 25285405
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).
    Miranda SR; Lee JK; Brouwer KL; Wen Z; Smith PC; Hawke RL
    Drug Metab Dispos; 2008 Nov; 36(11):2219-26. PubMed ID: 18687803
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.
    Westerink WM; Schoonen WG
    Toxicol In Vitro; 2007 Dec; 21(8):1581-91. PubMed ID: 17637504
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.
    Zhu HJ; Brinda BJ; Chavin KD; Bernstein HJ; Patrick KS; Markowitz JS
    Drug Metab Dispos; 2013 Sep; 41(9):1679-85. PubMed ID: 23835761
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA; Ehlhardt WJ; Jackson DA; Kulanthaivel P; Mutlib AE; Espina RJ; Moody DE; Crouch DJ; Yost GS
    Chem Res Toxicol; 2003 Mar; 16(3):336-49. PubMed ID: 12641434
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
    Deep G; Oberlies NH; Kroll DJ; Agarwal R
    Int J Cancer; 2008 Jul; 123(1):41-50. PubMed ID: 18435416
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities.
    Doehmer J; Weiss G; McGregor GP; Appel K
    Toxicol In Vitro; 2011 Feb; 25(1):21-7. PubMed ID: 20828605
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases.
    Vrba J; Papoušková B; Lněničková K; Kosina P; Křen V; Ulrichová J
    Antioxidants (Basel); 2021 Jun; 10(6):. PubMed ID: 34198653
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.
    Lee JI; Hsu BH; Wu D; Barrett JS
    J Chromatogr A; 2006 May; 1116(1-2):57-68. PubMed ID: 16631762
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.
    Vermeir M; Hemeryck A; Cuyckens F; Francesch A; Bockx M; Van Houdt J; Steemans K; Mannens G; Avilés P; De Coster R
    Biochem Pharmacol; 2009 May; 77(10):1642-54. PubMed ID: 19426702
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.
    Zhang D; Wang L; Chandrasena G; Ma L; Zhu M; Zhang H; Davis CD; Humphreys WG
    Drug Metab Dispos; 2007 Jan; 35(1):139-49. PubMed ID: 17062778
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.