233 related articles for article (PubMed ID: 29416044)
1. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Mahoney SJ; Narayan S; Molz L; Berstler LA; Kang SA; Vlasuk GP; Saiah E
Nat Commun; 2018 Feb; 9(1):548. PubMed ID: 29416044
[TBL] [Abstract][Full Text] [Related]
2. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
[TBL] [Abstract][Full Text] [Related]
3. HSP70 interacts with Rheb, inhibiting mTORC1 signaling.
Ryu HH; Ha SH
Biochem Biophys Res Commun; 2020 Dec; 533(4):1198-1203. PubMed ID: 33059920
[TBL] [Abstract][Full Text] [Related]
4. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Yang H; Jiang X; Li B; Yang HJ; Miller M; Yang A; Dhar A; Pavletich NP
Nature; 2017 Dec; 552(7685):368-373. PubMed ID: 29236692
[TBL] [Abstract][Full Text] [Related]
5. Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays.
Shams R; Ito Y; Miyatake H
Int J Mol Sci; 2021 Aug; 22(16):. PubMed ID: 34445471
[TBL] [Abstract][Full Text] [Related]
6. ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
Blackwood EA; Hofmann C; Santo Domingo M; Bilal AS; Sarakki A; Stauffer W; Arrieta A; Thuerauf DJ; Kolkhorst FW; Müller OJ; Jakobi T; Dieterich C; Katus HA; Doroudgar S; Glembotski CC
Circ Res; 2019 Jan; 124(1):79-93. PubMed ID: 30582446
[TBL] [Abstract][Full Text] [Related]
7. VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation.
Mohan N; Shen Y; Dokmanovic M; Endo Y; Hirsch DS; Wu WJ
Oncotarget; 2016 Aug; 7(32):52239-52254. PubMed ID: 27409169
[TBL] [Abstract][Full Text] [Related]
8. TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.
Xie J; De Poi SP; Humphrey SJ; Hein LK; Bruning JB; Pan W; Selth LA; Sargeant TJ; Proud CG
Cell Mol Life Sci; 2021 Apr; 78(8):4035-4052. PubMed ID: 33834258
[TBL] [Abstract][Full Text] [Related]
9. Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain.
Ma X; Du W; Wang W; Luo L; Huang M; Wang H; Lin R; Li Z; Shi H; Yuan T; Jiang W; Worley PF; Xu T
Cell Death Dis; 2020 Sep; 11(9):747. PubMed ID: 32920594
[TBL] [Abstract][Full Text] [Related]
10. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).
Shibutani S; Okazaki H; Iwata H
J Biol Chem; 2017 Nov; 292(44):18052-18061. PubMed ID: 28808055
[TBL] [Abstract][Full Text] [Related]
11. Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.
Deng L; Chen L; Zhao L; Xu Y; Peng X; Wang X; Ding L; Jin J; Teng H; Wang Y; Pan W; Yu F; Liao L; Li L; Ge X; Wang P
Cell Res; 2019 Feb; 29(2):136-150. PubMed ID: 30514904
[TBL] [Abstract][Full Text] [Related]
12. PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
Liu Z; Chen X; Wang Y; Peng H; Wang Y; Jing Y; Zhang H
J Biol Chem; 2014 Oct; 289(43):29739-49. PubMed ID: 25164809
[TBL] [Abstract][Full Text] [Related]
13. Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site.
Hao F; Kondo K; Itoh T; Ikari S; Nada S; Okada M; Noda T
J Cell Sci; 2018 Jan; 131(3):. PubMed ID: 29222112
[TBL] [Abstract][Full Text] [Related]
14. Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells.
Ahmed AR; Owens RJ; Stubbs CD; Parker AW; Hitchman R; Yadav RB; Dumoux M; Hawes C; Botchway SW
Sci Rep; 2019 Mar; 9(1):3408. PubMed ID: 30833605
[TBL] [Abstract][Full Text] [Related]
15. Rheb regulates nuclear mTORC1 activity independent of farnesylation.
Zhong Y; Zhou X; Guan KL; Zhang J
Cell Chem Biol; 2022 Jun; 29(6):1037-1045.e4. PubMed ID: 35294906
[TBL] [Abstract][Full Text] [Related]
16. Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors.
Melick CH; Jewell JL
Biochem J; 2020 May; 477(10):1847-1863. PubMed ID: 32347294
[TBL] [Abstract][Full Text] [Related]
17. Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
Mazhab-Jafari MT; Marshall CB; Ho J; Ishiyama N; Stambolic V; Ikura M
J Biol Chem; 2014 May; 289(18):12195-201. PubMed ID: 24648513
[TBL] [Abstract][Full Text] [Related]
18. Amino Acid-Mediated Intracellular Ca
Amemiya Y; Nakamura N; Ikeda N; Sugiyama R; Ishii C; Maki M; Shibata H; Takahara T
Int J Mol Sci; 2021 Jun; 22(13):. PubMed ID: 34198993
[TBL] [Abstract][Full Text] [Related]
19. Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation.
Sato T; Mukai S; Ikeda H; Mishiro-Sato E; Akao K; Kobayashi T; Hino O; Shimono W; Shibagaki Y; Hattori S; Sekido Y
Mol Cancer Res; 2021 May; 19(5):921-931. PubMed ID: 33574130
[TBL] [Abstract][Full Text] [Related]
20. Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
Zhang C; Liu Y; Zhang Y; Wang X; Zhang T; Ding J
J Mol Cell Biol; 2020 Sep; 12(9):741-744. PubMed ID: 32470140
[No Abstract] [Full Text] [Related]
[Next] [New Search]
