BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

214 related articles for article (PubMed ID: 29420337)

  • 1. Anticancer effect of (S)-crizotinib on osteosarcoma cells by targeting MTH1 and activating reactive oxygen species.
    Qing X; Shao Z; Lv X; Pu F; Gao F; Liu L; Shi D
    Anticancer Drugs; 2018 Apr; 29(4):341-352. PubMed ID: 29420337
    [TBL] [Abstract][Full Text] [Related]  

  • 2. (S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1.
    Dai X; Guo G; Zou P; Cui R; Chen W; Chen X; Yin C; He W; Vinothkumar R; Yang F; Zhang X; Liang G
    J Exp Clin Cancer Res; 2017 Sep; 36(1):120. PubMed ID: 28882182
    [TBL] [Abstract][Full Text] [Related]  

  • 3. (S)-crizotinib reduces gastric cancer growth through oxidative DNA damage and triggers pro-survival akt signal.
    Ji J; Chen W; Lian W; Chen R; Yang J; Zhang Q; Weng Q; Khan Z; Hu J; Chen X; Zou P; Chen X; Liang G
    Cell Death Dis; 2018 May; 9(6):660. PubMed ID: 29855474
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures.
    van der Waals LM; Laoukili J; Jongen JMJ; Raats DA; Borel Rinkes IHM; Kranenburg O
    Sci Rep; 2019 Jan; 9(1):819. PubMed ID: 30692572
    [TBL] [Abstract][Full Text] [Related]  

  • 5. TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.
    Moukengue B; Brown HK; Charrier C; Battaglia S; Baud'huin M; Quillard T; Pham TM; Pateras IS; Gorgoulis VG; Helleday T; Heymann D; Berglund UW; Ory B; Lamoureux F
    EBioMedicine; 2020 Mar; 53():102704. PubMed ID: 32151797
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Anticancer effect of crizotinib on osteosarcoma cells by targeting c-Met signaling pathway.
    Jia T; Cai M; Wang Z; Chen T
    Cell Mol Biol (Noisy-le-grand); 2023 May; 69(5):174-178. PubMed ID: 37571883
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
    Huber KV; Salah E; Radic B; Gridling M; Elkins JM; Stukalov A; Jemth AS; Göktürk C; Sanjiv K; Strömberg K; Pham T; Berglund UW; Colinge J; Bennett KL; Loizou JI; Helleday T; Knapp S; Superti-Furga G
    Nature; 2014 Apr; 508(7495):222-7. PubMed ID: 24695225
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma.
    Huang X; Chen J; Wu W; Yang W; Zhong B; Qing X; Shao Z
    Acta Biomater; 2020 Jun; 109():229-243. PubMed ID: 32294550
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?
    Abbas HHK; Alhamoudi KMH; Evans MD; Jones GDD; Foster SS
    BMC Cancer; 2018 Apr; 18(1):423. PubMed ID: 29661172
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha.
    Bhavya B; Easwer HV; Vilanilam GC; Anand CR; Sreelakshmi K; Urulangodi M; Rajalakshmi P; Neena I; Padmakrishnan CJ; Menon GR; Krishnakumar K; Deepti AN; Gopala S
    Life Sci; 2021 Jan; 264():118673. PubMed ID: 33130078
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potent and specific MTH1 inhibitors targeting gastric cancer.
    Zhou W; Ma L; Yang J; Qiao H; Li L; Guo Q; Ma J; Zhao L; Wang J; Jiang G; Wan X; Adam Goscinski M; Ding L; Zheng Y; Li W; Liu H; Suo Z; Zhao W
    Cell Death Dis; 2019 Jun; 10(6):434. PubMed ID: 31164636
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alternol, a natural compound, exerts an anti-tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways.
    Zuo D; Zhou Z; Wang H; Zhang T; Zang J; Yin F; Sun W; Chen J; Duan L; Xu J; Wang Z; Wang C; Lin B; Fu Z; Liao Y; Li S; Sun M; Hua Y; Zheng L; Cai Z
    J Cell Mol Med; 2017 Feb; 21(2):208-221. PubMed ID: 27624867
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.
    Niu NK; Wang ZL; Pan ST; Ding HQ; Au GH; He ZX; Zhou ZW; Xiao G; Yang YX; Zhang X; Yang T; Chen XW; Qiu JX; Zhou SF
    Drug Des Devel Ther; 2015; 9():1555-84. PubMed ID: 25792811
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ouabain Induces Apoptotic Cell Death Through Caspase- and Mitochondria-dependent Pathways in Human Osteosarcoma U-2 OS Cells.
    Chou WH; Liu KL; Shih YL; Chuang YY; Chou J; Lu HF; Jair HW; Lee MZ; Au MK; Chung JG
    Anticancer Res; 2018 Jan; 38(1):169-178. PubMed ID: 29277770
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Antitumor effects of MutT homolog 1 inhibitors in human bladder cancer cells.
    Lee JW; Lee S; Ho JN; Youn JI; Byun SS; Lee E
    Biosci Biotechnol Biochem; 2019 Dec; 83(12):2265-2271. PubMed ID: 31362565
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Gadolinium chloride elicits apoptosis in human osteosarcoma U-2 OS cells through extrinsic signaling, intrinsic pathway and endoplasmic reticulum stress.
    Tsai YF; Huang CW; Chiang JH; Tsai FJ; Hsu YM; Lu CC; Hsiao CY; Yang JS
    Oncol Rep; 2016 Dec; 36(6):3421-3426. PubMed ID: 27748868
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Influence of Chirality of Crizotinib on Its MTH1 Protein Inhibitory Activity: Insight from Molecular Dynamics Simulations and Binding Free Energy Calculations.
    Niu Y; Pan D; Shi D; Bai Q; Liu H; Yao X
    PLoS One; 2015; 10(12):e0145219. PubMed ID: 26677850
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition.
    Megiorni F; McDowell HP; Camero S; Mannarino O; Ceccarelli S; Paiano M; Losty PD; Pizer B; Shukla R; Pizzuti A; Clerico A; Dominici C
    J Exp Clin Cancer Res; 2015 Oct; 34():112. PubMed ID: 26445453
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen‑activated protein kinase pathway.
    Zhang Y; Deng X; Lei T; Yu C; Wang Y; Zhao G; Luo X; Tang K; Quan Z; Jiang D
    Oncol Rep; 2017 Nov; 38(5):2685-2696. PubMed ID: 29048662
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia.
    Pompsch M; Vogel J; Classen F; Kranz P; Iliakis G; Riffkin H; Brockmeier U; Metzen E
    BMC Cancer; 2018 Nov; 18(1):1190. PubMed ID: 30497423
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.