These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 29428410)

  • 1. Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
    Meng N; Tang H; Zhang H; Jiang C; Su L; Min X; Zhang W; Zhang H; Miao Z; Zhang W; Zhuang C
    Free Radic Biol Med; 2018 Mar; 117():228-237. PubMed ID: 29428410
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
    Bresciani A; Missineo A; Gallo M; Cerretani M; Fezzardi P; Tomei L; Cicero DO; Altamura S; Santoprete A; Ingenito R; Bianchi E; Pacifici R; Dominguez C; Munoz-Sanjuan I; Harper S; Toledo-Sherman L; Park LC
    Arch Biochem Biophys; 2017 Oct; 631():31-41. PubMed ID: 28801166
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
    Zhang L; Xu L; Chen H; Zhang W; Xing C; Qu Z; Yu J; Zhuang C
    Eur J Med Chem; 2021 Oct; 222():113599. PubMed ID: 34119834
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency.
    Lu MC; Jiao Q; Liu T; Tan SJ; Zhou HS; You QD; Jiang ZY
    Eur J Med Chem; 2018 Jan; 143():1578-1589. PubMed ID: 29117896
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and evaluation of novel small molecules acting as Keap1-Nrf2 protein-protein interaction inhibitors.
    Sun Y; Zheng L; Yang B; Ge S; Li Q; Zhang M; Shen S; Ying Y
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):2575-2588. PubMed ID: 36128875
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy.
    Jiang CS; Zhuang CL; Zhu K; Zhang J; Muehlmann LA; Figueiró Longo JP; Azevedo RB; Zhang W; Meng N; Zhang H
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):833-841. PubMed ID: 29693453
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
    Davies TG; Wixted WE; Coyle JE; Griffiths-Jones C; Hearn K; McMenamin R; Norton D; Rich SJ; Richardson C; Saxty G; Willems HM; Woolford AJ; Cottom JE; Kou JP; Yonchuk JG; Feldser HG; Sanchez Y; Foley JP; Bolognese BJ; Logan G; Podolin PL; Yan H; Callahan JF; Heightman TD; Kerns JK
    J Med Chem; 2016 Apr; 59(8):3991-4006. PubMed ID: 27031670
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.
    Lu MC; Shao HL; Liu T; You QD; Jiang ZY
    Eur J Med Chem; 2020 Dec; 207():112734. PubMed ID: 32866756
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of Keap1-Nrf2 small-molecule inhibitors from phytochemicals based on molecular docking.
    Li M; Huang W; Jie F; Wang M; Zhong Y; Chen Q; Lu B
    Food Chem Toxicol; 2019 Nov; 133():110758. PubMed ID: 31412289
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
    Jiang ZY; Lu MC; Xu LL; Yang TT; Xi MY; Xu XL; Guo XK; Zhang XJ; You QD; Sun HP
    J Med Chem; 2014 Mar; 57(6):2736-45. PubMed ID: 24512214
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions.
    Jiang ZY; Lu MC; You QD
    J Med Chem; 2016 Dec; 59(24):10837-10858. PubMed ID: 27690435
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia.
    Chiou YS; Huang Q; Ho CT; Wang YJ; Pan MH
    Free Radic Biol Med; 2016 May; 94():1-16. PubMed ID: 26878775
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    Zhou HS; Hu LB; Zhang H; Shan WX; Wang Y; Li X; Liu T; Zhao J; You QD; Jiang ZY
    J Med Chem; 2020 Oct; 63(19):11149-11168. PubMed ID: 32902980
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line.
    Cui B; Zhang S; Wang Y; Guo Y
    Biomed Pharmacother; 2019 Jan; 109():112-119. PubMed ID: 30396067
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors.
    Leung CH; Zhang JT; Yang GJ; Liu H; Han QB; Ma DL
    Int J Mol Sci; 2019 Sep; 20(18):. PubMed ID: 31509940
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction.
    Lee S; Abed DA; Beamer LJ; Hu L
    SLAS Discov; 2021 Jan; 26(1):100-112. PubMed ID: 32564647
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction.
    Abed DA; Lee S; Hu L
    Bioorg Med Chem; 2020 Mar; 28(6):115343. PubMed ID: 32046917
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
    Huerta C; Jiang X; Trevino I; Bender CF; Ferguson DA; Probst B; Swinger KK; Stoll VS; Thomas PJ; Dulubova I; Visnick M; Wigley WC
    Biochim Biophys Acta; 2016 Nov; 1860(11 Pt A):2537-2552. PubMed ID: 27474998
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular recognition between potential natural inhibitors of the Keap1-Nrf2 complex.
    Bello M; Morales-González JA
    Int J Biol Macromol; 2017 Dec; 105(Pt 1):981-992. PubMed ID: 28746889
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Protein-Protein Interaction.
    Zhang Y; Shi Z; Zhou Y; Xiao Q; Wang H; Peng Y
    J Med Chem; 2020 Aug; 63(15):7986-8002. PubMed ID: 32233486
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.