BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 29429898)

  • 1. Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase.
    Kim HT; Na BK; Chung J; Kim S; Kwon SK; Cha H; Son J; Cho JM; Hwang KY
    Cell Chem Biol; 2018 Apr; 25(4):426-438.e4. PubMed ID: 29429898
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Kynurenine 3-monooxygenase from Pseudomonas fluorescens: substrate-like inhibitors both stimulate flavin reduction and stabilize the flavin-peroxo intermediate yet result in the production of hydrogen peroxide.
    Crozier-Reabe KR; Phillips RS; Moran GR
    Biochemistry; 2008 Nov; 47(47):12420-33. PubMed ID: 18954092
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.
    Gao J; Yao L; Xia T; Liao X; Zhu D; Xiang Y
    FASEB J; 2018 Apr; 32(4):2036-2045. PubMed ID: 29208702
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis of kynurenine 3-monooxygenase inhibition.
    Amaral M; Levy C; Heyes DJ; Lafite P; Outeiro TF; Giorgini F; Leys D; Scrutton NS
    Nature; 2013 Apr; 496(7445):382-5. PubMed ID: 23575632
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hydrogen movements in the oxidative half-reaction of kynurenine 3-monooxygenase from Pseudomonas fluorescens reveal the mechanism of hydroxylation.
    Beaupre BA; Reabe KR; Roman JV; Moran GR
    Arch Biochem Biophys; 2020 Sep; 690():108474. PubMed ID: 32687799
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase.
    Gotina L; Seo SH; Kim CW; Lim SM; Pae AN
    Molecules; 2021 May; 26(11):. PubMed ID: 34073016
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
    Hutchinson JP; Rowland P; Taylor MRD; Christodoulou EM; Haslam C; Hobbs CI; Holmes DS; Homes P; Liddle J; Mole DJ; Uings I; Walker AL; Webster SP; Mowat CG; Chung CW
    Nat Commun; 2017 Jun; 8():15827. PubMed ID: 28604669
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Heterologous expression and purification of kynurenine-3-monooxygenase from Pseudomonas fluorescens strain 17400.
    Crozier KR; Moran GR
    Protein Expr Purif; 2007 Feb; 51(2):324-33. PubMed ID: 16973376
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors.
    Smith JR; Jamie JF; Guillemin GJ
    Drug Discov Today; 2016 Feb; 21(2):315-24. PubMed ID: 26589832
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii.
    Phillips RS; Anderson AD; Gentry HG; Güner OF; Bowen JP
    Bioorg Med Chem Lett; 2017 Apr; 27(8):1705-1708. PubMed ID: 28302400
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors.
    Hughes TD; Güner OF; Iradukunda EC; Phillips RS; Bowen JP
    Molecules; 2022 Jan; 27(1):. PubMed ID: 35011505
    [TBL] [Abstract][Full Text] [Related]  

  • 12. N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors.
    Kimura H; Suda H; Kassai M; Endo M; Deai Y; Yahata M; Miyajima M; Isobe Y
    Bioorg Med Chem Lett; 2021 Feb; 33():127753. PubMed ID: 33359168
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model.
    Zakhary G; Sherchan P; Li Q; Tang J; Zhang JH
    J Neurosci Res; 2020 Jan; 98(1):155-167. PubMed ID: 31257634
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
    Giménez-Gómez P; Pérez-Hernández M; Gutiérrez-López MD; Vidal R; Abuin-Martínez C; O'Shea E; Colado MI
    Neuropharmacology; 2018 Jun; 135():581-591. PubMed ID: 29705534
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase.
    Poda SB; Kobayashi M; Nachane R; Menon V; Gandhi AS; Budac DP; Li G; Campbell BM; Tagmose L
    Assay Drug Dev Technol; 2015 Oct; 13(8):466-75. PubMed ID: 26292018
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.
    Mimasu S; Yamagishi H; Kubo S; Kiyohara M; Matsuda T; Yahata T; Thomson HA; Hupp CD; Liu J; Okuda T; Kakefuda K
    Commun Biol; 2021 Feb; 4(1):159. PubMed ID: 33542467
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases.
    Zhang S; Collier MEW; Heyes DJ; Giorgini F; Scrutton NS
    Arch Biochem Biophys; 2021 Jan; 697():108702. PubMed ID: 33275878
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression.
    Chen Y; Zhang J; Yang Y; Xiang K; Li H; Sun D; Chen L
    J Cell Physiol; 2022 Dec; 237(12):4339-4355. PubMed ID: 36088660
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.
    Wilson K; Mole DJ; Homer NZ; Iredale JP; Auer M; Webster SP
    J Biomol Screen; 2015 Feb; 20(2):292-8. PubMed ID: 25296660
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).
    Winkler D; Beconi M; Toledo-Sherman LM; Prime M; Ebneth A; Dominguez C; Muñoz-Sanjuan I
    J Biomol Screen; 2013 Sep; 18(8):879-89. PubMed ID: 23690293
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.