161 related articles for article (PubMed ID: 29430850)
1. Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.
Narayanan B; Lade JM; Heck CJS; Dietz KD; Wade H; Bumpus NN
ChemMedChem; 2018 Apr; 13(7):736-747. PubMed ID: 29430850
[TBL] [Abstract][Full Text] [Related]
2. Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1
Heck CJS; Hamlin AN; Bumpus NN
Mol Pharmacol; 2019 Feb; 95(2):183-195. PubMed ID: 30442673
[TBL] [Abstract][Full Text] [Related]
3. Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes.
Bumpus NN
Toxicol Appl Pharmacol; 2011 Dec; 257(2):227-34. PubMed ID: 21958719
[TBL] [Abstract][Full Text] [Related]
4. Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor.
Burk O; Kronenberger T; Keminer O; Lee SML; Schiergens TS; Schwab M; Windshügel B
Mol Pharmacol; 2021 Mar; 99(3):184-196. PubMed ID: 33483427
[TBL] [Abstract][Full Text] [Related]
5. Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation.
Reddy RT; Nyunoya T
Biochem Biophys Res Commun; 2021 May; 555():1-6. PubMed ID: 33812052
[TBL] [Abstract][Full Text] [Related]
6. Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.
Jeske J; Windshügel B; Thasler WE; Schwab M; Burk O
Arch Toxicol; 2017 Jun; 91(6):2375-2390. PubMed ID: 28289823
[TBL] [Abstract][Full Text] [Related]
7. Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
Miao X; Ye H; Cui X; Guo X; Su F
Nutr Res; 2023 Nov; 119():119-131. PubMed ID: 37826994
[TBL] [Abstract][Full Text] [Related]
8. Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis.
Gwag T; Meng Z; Sui Y; Helsley RN; Park SH; Wang S; Greenberg RN; Zhou C
J Hepatol; 2019 May; 70(5):930-940. PubMed ID: 30677459
[TBL] [Abstract][Full Text] [Related]
9. Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.
Burk O; Kuzikov M; Kronenberger T; Jeske J; Keminer O; Thasler WE; Schwab M; Wrenger C; Windshügel B
Arch Toxicol; 2018 Apr; 92(4):1435-1451. PubMed ID: 29356861
[TBL] [Abstract][Full Text] [Related]
10. The Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In Vitro.
Mast N; Fotinich A; Pikuleva IA
Drug Metab Dispos; 2022 Jul; 50(7):923-930. PubMed ID: 35489779
[TBL] [Abstract][Full Text] [Related]
11. Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity.
Toyama H; Shirakawa H; Komai M; Hashimoto Y; Fujii S
Bioorg Med Chem; 2018 Aug; 26(15):4493-4501. PubMed ID: 30077610
[TBL] [Abstract][Full Text] [Related]
12. Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.
Carazo A; Hyrsova L; Dusek J; Chodounska H; Horvatova A; Berka K; Bazgier V; Gan-Schreier H; Chamulitrat W; Kudova E; Pavek P
Toxicol Lett; 2017 Jan; 265():86-96. PubMed ID: 27871908
[TBL] [Abstract][Full Text] [Related]
13. Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.
Moscovitz JE; Lin Z; Johnson N; Tu M; Goosen TC; Weng Y; Kalgutkar AS
Xenobiotica; 2018 Jul; 48(7):647-655. PubMed ID: 28685622
[TBL] [Abstract][Full Text] [Related]
14. Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.
Huang L; Huang M; Li YH; Li RM; Zeng Y; Kuang SY; Zhang L; Wang YT; Bi HC
J Ethnopharmacol; 2013 Jul; 148(2):596-602. PubMed ID: 23702042
[TBL] [Abstract][Full Text] [Related]
15. Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction.
Lin W; Chen T
Adv Protein Chem Struct Biol; 2018; 110():31-63. PubMed ID: 29412999
[TBL] [Abstract][Full Text] [Related]
16. Deciphering structural bases of intestinal and hepatic selectivity in targeting pregnane X receptor with indole-based microbial mimics.
Li H; Illés P; Karunaratne CV; Nordstrøm LU; Luo X; Yang A; Qiu Y; Kurland IJ; Lukin DJ; Chen W; Jiskrová E; Krasulová K; Pečinková P; DesMarais VM; Liu Q; Albanese JM; Akki A; Longo M; Coffin B; Dou W; Mani S; Dvořák Z
Bioorg Chem; 2021 Apr; 109():104661. PubMed ID: 33636438
[TBL] [Abstract][Full Text] [Related]
17. No activation of human pregnane X receptor by hyperforin-related phloroglucinols.
Kandel BA; Ekins S; Leuner K; Thasler WE; Harteneck C; Zanger UM
J Pharmacol Exp Ther; 2014 Mar; 348(3):393-400. PubMed ID: 24259679
[TBL] [Abstract][Full Text] [Related]
18. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
Healan-Greenberg C; Waring JF; Kempf DJ; Blomme EA; Tirona RG; Kim RB
Drug Metab Dispos; 2008 Mar; 36(3):500-7. PubMed ID: 18096673
[TBL] [Abstract][Full Text] [Related]
19. Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
Lemaire G; Benod C; Nahoum V; Pillon A; Boussioux AM; Guichou JF; Subra G; Pascussi JM; Bourguet W; Chavanieu A; Balaguer P
Mol Pharmacol; 2007 Sep; 72(3):572-81. PubMed ID: 17573484
[TBL] [Abstract][Full Text] [Related]
20. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.
Ding X; Lichti K; Staudinger JL
Toxicol Sci; 2006 Jun; 91(2):448-55. PubMed ID: 16547076
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]