171 related articles for article (PubMed ID: 29440291)
21. Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature.
Thompson SK; Buckl A; Dossetter AG; Griffen E; Gill A
Expert Opin Ther Pat; 2021 Dec; 31(12):1189-1204. PubMed ID: 34253125
[No Abstract] [Full Text] [Related]
22. Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Abbott JR; Hodges TR; Daniels RN; Patel PA; Kennedy JP; Howes JE; Akan DT; Burns MC; Sai J; Sobolik T; Beesetty Y; Lee T; Rossanese OW; Phan J; Waterson AG; Fesik SW
J Med Chem; 2018 Jul; 61(14):6002-6017. PubMed ID: 29856609
[TBL] [Abstract][Full Text] [Related]
23. Targeted Covalent Inhibition of Grb2-Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells.
Yu Y; Nie Y; Feng Q; Qu J; Wang R; Bian L; Xia J
Mol Pharm; 2017 May; 14(5):1548-1557. PubMed ID: 28060514
[TBL] [Abstract][Full Text] [Related]
24. Targeting RAS oncogenesis with SOS1 inhibitors.
Hillig RC; Bader B
Adv Cancer Res; 2022; 153():169-203. PubMed ID: 35101230
[TBL] [Abstract][Full Text] [Related]
25. Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis.
Jang SI; Lee EJ; Hart PS; Ramaswami M; Pallos D; Hart TC
J Biol Chem; 2007 Jul; 282(28):20245-55. PubMed ID: 17510059
[TBL] [Abstract][Full Text] [Related]
26. Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles.
Liao TJ; Jang H; Fushman D; Nussinov R
Biophys J; 2018 Aug; 115(4):629-641. PubMed ID: 30097175
[TBL] [Abstract][Full Text] [Related]
27. p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells.
Arany I; Faisal A; Nagamine Y; Safirstein RL
J Biol Chem; 2008 Mar; 283(10):6110-7. PubMed ID: 18174162
[TBL] [Abstract][Full Text] [Related]
28. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC; Sautier B; Schroeder J; Moosmayer D; Hilpmann A; Stegmann CM; Werbeck ND; Briem H; Boemer U; Weiske J; Badock V; Mastouri J; Petersen K; Siemeister G; Kahmann JD; Wegener D; Böhnke N; Eis K; Graham K; Wortmann L; von Nussbaum F; Bader B
Proc Natl Acad Sci U S A; 2019 Feb; 116(7):2551-2560. PubMed ID: 30683722
[TBL] [Abstract][Full Text] [Related]
29. Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.
Winter JJ; Anderson M; Blades K; Brassington C; Breeze AL; Chresta C; Embrey K; Fairley G; Faulder P; Finlay MR; Kettle JG; Nowak T; Overman R; Patel SJ; Perkins P; Spadola L; Tart J; Tucker JA; Wrigley G
J Med Chem; 2015 Mar; 58(5):2265-74. PubMed ID: 25695162
[TBL] [Abstract][Full Text] [Related]
30. CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1.
Hwang HS; Hwang SG; Cho JH; Chae JS; Yoon KW; Cho SG; Choi EJ
J Cell Biol; 2011 Oct; 195(3):377-86. PubMed ID: 22042618
[TBL] [Abstract][Full Text] [Related]
31. Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.
Wu Y; Chen Y; Qu R; Lan T; Sang J
Oncol Rep; 2012 Feb; 27(2):553-8. PubMed ID: 22012247
[TBL] [Abstract][Full Text] [Related]
32. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers.
Nichols RJ; Haderk F; Stahlhut C; Schulze CJ; Hemmati G; Wildes D; Tzitzilonis C; Mordec K; Marquez A; Romero J; Hsieh T; Zaman A; Olivas V; McCoach C; Blakely CM; Wang Z; Kiss G; Koltun ES; Gill AL; Singh M; Goldsmith MA; Smith JAM; Bivona TG
Nat Cell Biol; 2018 Sep; 20(9):1064-1073. PubMed ID: 30104724
[TBL] [Abstract][Full Text] [Related]
33. Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Burns MC; Sun Q; Daniels RN; Camper D; Kennedy JP; Phan J; Olejniczak ET; Lee T; Waterson AG; Rossanese OW; Fesik SW
Proc Natl Acad Sci U S A; 2014 Mar; 111(9):3401-6. PubMed ID: 24550516
[TBL] [Abstract][Full Text] [Related]
34. Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis.
Dangi S; Shapiro P
J Biol Chem; 2005 Jul; 280(26):24524-31. PubMed ID: 15888452
[TBL] [Abstract][Full Text] [Related]
35. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.
Innocenti M; Tenca P; Frittoli E; Faretta M; Tocchetti A; Di Fiore PP; Scita G
J Cell Biol; 2002 Jan; 156(1):125-36. PubMed ID: 11777939
[TBL] [Abstract][Full Text] [Related]
36. Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
Kortum RL; Rouquette-Jazdanian AK; Samelson LE
Trends Immunol; 2013 Jun; 34(6):259-68. PubMed ID: 23506953
[TBL] [Abstract][Full Text] [Related]
37. Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.
Mazalouskas MD; Godoy-Ruiz R; Weber DJ; Zimmer DB; Honkanen RE; Wadzinski BE
J Biol Chem; 2014 Feb; 289(7):4219-32. PubMed ID: 24371145
[TBL] [Abstract][Full Text] [Related]
38. Direct inhibition of oncogenic KRAS by Bacillus pumilus ribonuclease (binase).
Ilinskaya ON; Singh I; Dudkina E; Ulyanova V; Kayumov A; Barreto G
Biochim Biophys Acta; 2016 Jul; 1863(7 Pt A):1559-67. PubMed ID: 27066977
[TBL] [Abstract][Full Text] [Related]
39. Understanding SOS (Son of Sevenless).
Pierre S; Bats AS; Coumoul X
Biochem Pharmacol; 2011 Nov; 82(9):1049-56. PubMed ID: 21787760
[TBL] [Abstract][Full Text] [Related]
40. SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.
Dong Chen ; Waters SB; Holt KH; Pessin JE
J Biol Chem; 1996 Mar; 271(11):6328-32. PubMed ID: 8626428
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
