BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 29443039)

  • 1. Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms.
    Wang BJ; Wu PY; Chen YW; Chang YT; Bhore N; Wu PF; Liao YF
    J Vis Exp; 2018 Jan; (131):. PubMed ID: 29443039
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway.
    Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
    J Biol Chem; 2004 Nov; 279(47):49523-32. PubMed ID: 15347683
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
    Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W
    Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.
    Liao YF; Wang BJ; Hsu WM; Lee H; Liao CY; Wu SY; Cheng HT; Hu MK
    Mol Pharmacol; 2007 Feb; 71(2):588-601. PubMed ID: 17105873
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain.
    Castro MA; Parson KF; Beg I; Wilkinson MC; Nurmakova K; Levesque I; Voehler MW; Wolfe MS; Ruotolo BT; Sanders CR
    J Biol Chem; 2022 Apr; 298(4):101792. PubMed ID: 35247387
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
    Kokawa A; Ishihara S; Fujiwara H; Nobuhara M; Iwata M; Ihara Y; Funamoto S
    Acta Neuropathol Commun; 2015 Nov; 3():66. PubMed ID: 26531305
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
    Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
    J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay.
    Law BM; Guest AL; Pullen MWJ; Perkinton MS; Williams RJ
    J Alzheimers Dis; 2018; 61(2):673-688. PubMed ID: 29254083
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Defining the minimum substrate and charge recognition model of gamma-secretase.
    Yan Y; Xu TH; Melcher K; Xu HE
    Acta Pharmacol Sin; 2017 Oct; 38(10):1412-1424. PubMed ID: 28414207
    [TBL] [Abstract][Full Text] [Related]  

  • 11. An improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates.
    McKee TD; Loureiro RM; Dumin JA; Zarayskiy V; Tate B
    J Neurosci Methods; 2013 Feb; 213(1):14-21. PubMed ID: 23219895
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of small molecular (D)-leucinamides as potent, Notch-sparing γ-secretase modulators.
    Liao YF; Tang YC; Chang MY; Wang BJ; Hu MK
    Eur J Med Chem; 2014 May; 79():143-51. PubMed ID: 24732790
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activity of gamma-secretase on substrates other than APP.
    Lleó A
    Curr Top Med Chem; 2008; 8(1):9-16. PubMed ID: 18220928
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ethanol inhibits γ-secretase proteolytic activity in vascular smooth muscle cells.
    Hatch E; Morrow D; Liu W; Cahill PA; Redmond EM
    Alcohol Clin Exp Res; 2015 Nov; 39(11):2115-22. PubMed ID: 26443551
    [TBL] [Abstract][Full Text] [Related]  

  • 15. High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease.
    Florean C; Zampese E; Zanese M; Brunello L; Ichas F; De Giorgi F; Pizzo P
    Biochim Biophys Acta; 2008 Aug; 1783(8):1551-60. PubMed ID: 18424271
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.
    Groth C; Alvord WG; Quiñones OA; Fortini ME
    Mol Pharmacol; 2010 Apr; 77(4):567-74. PubMed ID: 20064975
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of a Reporter System for
    Hong YG; Roh S; Paik D; Jeong S
    Mol Cells; 2017 Jan; 40(1):73-81. PubMed ID: 28152299
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
    Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
    Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
    [TBL] [Abstract][Full Text] [Related]  

  • 19. X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
    King GD; Cherian K; Turner RS
    J Neurochem; 2004 Feb; 88(4):971-82. PubMed ID: 14756819
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Assay to probe proteolytic processing of Notch by γ-secretase.
    Serneels L; Tesseur I; De Strooper B
    Methods Mol Biol; 2014; 1187():223-9. PubMed ID: 25053493
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.