These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
635 related articles for article (PubMed ID: 29449372)
1. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. Akuffo AA; Alontaga AY; Metcalf R; Beatty MS; Becker A; McDaniel JM; Hesterberg RS; Goodheart WE; Gunawan S; Ayaz M; Yang Y; Karim MR; Orobello ME; Daniel K; Guida W; Yoder JA; Rajadhyaksha AM; Schönbrunn E; Lawrence HR; Lawrence NJ; Epling-Burnette PK J Biol Chem; 2018 Apr; 293(16):6187-6200. PubMed ID: 29449372 [TBL] [Abstract][Full Text] [Related]
2. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). Gandhi AK; Kang J; Havens CG; Conklin T; Ning Y; Wu L; Ito T; Ando H; Waldman MF; Thakurta A; Klippel A; Handa H; Daniel TO; Schafer PH; Chopra R Br J Haematol; 2014 Mar; 164(6):811-21. PubMed ID: 24328678 [TBL] [Abstract][Full Text] [Related]
3. Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs. Lindner S; Steinebach C; Kehm H; Mangold M; Gütschow M; Krönke J J Vis Exp; 2019 May; (147):. PubMed ID: 31157769 [TBL] [Abstract][Full Text] [Related]
4. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Fischer ES; Böhm K; Lydeard JR; Yang H; Stadler MB; Cavadini S; Nagel J; Serluca F; Acker V; Lingaraju GM; Tichkule RB; Schebesta M; Forrester WC; Schirle M; Hassiepen U; Ottl J; Hild M; Beckwith RE; Harper JW; Jenkins JL; Thomä NH Nature; 2014 Aug; 512(7512):49-53. PubMed ID: 25043012 [TBL] [Abstract][Full Text] [Related]
5. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Chamberlain PP; Lopez-Girona A; Miller K; Carmel G; Pagarigan B; Chie-Leon B; Rychak E; Corral LG; Ren YJ; Wang M; Riley M; Delker SL; Ito T; Ando H; Mori T; Hirano Y; Handa H; Hakoshima T; Daniel TO; Cathers BE Nat Struct Mol Biol; 2014 Sep; 21(9):803-9. PubMed ID: 25108355 [TBL] [Abstract][Full Text] [Related]
6. CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Fu SJ; Hu MC; Peng YJ; Fang HY; Hsiao CT; Chen TY; Jeng CJ; Tang CY Cells; 2020 May; 9(6):. PubMed ID: 32466489 [TBL] [Abstract][Full Text] [Related]
7. A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function. Liu Y; Huang X; He X; Zhou Y; Jiang X; Chen-Kiang S; Jaffrey SR; Xu G FASEB J; 2015 Dec; 29(12):4829-39. PubMed ID: 26231201 [TBL] [Abstract][Full Text] [Related]
8. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Nguyen TV; Lee JE; Sweredoski MJ; Yang SJ; Jeon SJ; Harrison JS; Yim JH; Lee SG; Handa H; Kuhlman B; Jeong JS; Reitsma JM; Park CS; Hess S; Deshaies RJ Mol Cell; 2016 Mar; 61(6):809-20. PubMed ID: 26990986 [TBL] [Abstract][Full Text] [Related]
9. UBE2G1 governs the destruction of cereblon neomorphic substrates. Lu G; Weng S; Matyskiela M; Zheng X; Fang W; Wood S; Surka C; Mizukoshi R; Lu CC; Mendy D; Jang IS; Wang K; Marella M; Couto S; Cathers B; Carmichael J; Chamberlain P; Rolfe M Elife; 2018 Sep; 7():. PubMed ID: 30234487 [TBL] [Abstract][Full Text] [Related]
10. Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway. Collins I; Wang H; Caldwell JJ; Chopra R Biochem J; 2017 Mar; 474(7):1127-1147. PubMed ID: 28298557 [TBL] [Abstract][Full Text] [Related]
11. Generation of a lenalidomide-sensitive syngeneic murine in vivo multiple myeloma model by expression of Crbn Röhner L; Ng YLD; Scheffold A; Lindner S; Köpff S; Brandl A; Beilhack A; Krönke J Exp Hematol; 2021 Jan; 93():61-69.e4. PubMed ID: 33186626 [TBL] [Abstract][Full Text] [Related]
12. Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase. Petzold G; Fischer ES; Thomä NH Nature; 2016 Apr; 532(7597):127-30. PubMed ID: 26909574 [TBL] [Abstract][Full Text] [Related]
13. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Sievers QL; Petzold G; Bunker RD; Renneville A; Słabicki M; Liddicoat BJ; Abdulrahman W; Mikkelsen T; Ebert BL; Thomä NH Science; 2018 Nov; 362(6414):. PubMed ID: 30385546 [TBL] [Abstract][Full Text] [Related]
14. Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4. Belair DG; Lu G; Waller LE; Gustin JA; Collins ND; Kolaja KL Sci Rep; 2020 Feb; 10(1):2864. PubMed ID: 32071327 [TBL] [Abstract][Full Text] [Related]
15. Homo-PROTACs for the Chemical Knockdown of Cereblon. Steinebach C; Lindner S; Udeshi ND; Mani DC; Kehm H; Köpff S; Carr SA; Gütschow M; Krönke J ACS Chem Biol; 2018 Sep; 13(9):2771-2782. PubMed ID: 30118587 [TBL] [Abstract][Full Text] [Related]
16. Targeting cereblon in hematologic malignancies. Fuchs O Blood Rev; 2023 Jan; 57():100994. PubMed ID: 35933246 [TBL] [Abstract][Full Text] [Related]
17. Development of Phenyl-substituted Isoindolinone- and Benzimidazole-type Cereblon Ligands for Targeted Protein Degradation. Nie X; Zhao Y; Tang H; Zhang Z; Liao J; Almodovar-Rivera CM; Sundaresan R; Xie H; Guo L; Wang B; Guan H; Xing Y; Tang W Chembiochem; 2024 Feb; 25(4):e202300685. PubMed ID: 38116854 [TBL] [Abstract][Full Text] [Related]
18. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Winter GE; Buckley DL; Paulk J; Roberts JM; Souza A; Dhe-Paganon S; Bradner JE Science; 2015 Jun; 348(6241):1376-81. PubMed ID: 25999370 [TBL] [Abstract][Full Text] [Related]
19. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Shen C; Nayak A; Neitzel LR; Adams AA; Silver-Isenstadt M; Sawyer LM; Benchabane H; Wang H; Bunnag N; Li B; Wynn DT; Yang F; Garcia-Contreras M; Williams CH; Dakshanamurthy S; Hong CC; Ayad NG; Capobianco AJ; Ahmed Y; Lee E; Robbins DJ Nat Commun; 2021 Sep; 12(1):5263. PubMed ID: 34489457 [TBL] [Abstract][Full Text] [Related]