BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

393 related articles for article (PubMed ID: 29449635)

  • 1. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin.
    Sundberg M; Tochitsky I; Buchholz DE; Winden K; Kujala V; Kapur K; Cataltepe D; Turner D; Han MJ; Woolf CJ; Hatten ME; Sahin M
    Mol Psychiatry; 2018 Nov; 23(11):2167-2183. PubMed ID: 29449635
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.
    Tsai PT; Hull C; Chu Y; Greene-Colozzi E; Sadowski AR; Leech JM; Steinberg J; Crawley JN; Regehr WG; Sahin M
    Nature; 2012 Aug; 488(7413):647-51. PubMed ID: 22763451
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration.
    Reith RM; Way S; McKenna J; Haines K; Gambello MJ
    Neurobiol Dis; 2011 Jul; 43(1):113-22. PubMed ID: 21419848
    [TBL] [Abstract][Full Text] [Related]  

  • 4. mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis.
    Costa V; Aigner S; Vukcevic M; Sauter E; Behr K; Ebeling M; Dunkley T; Friedlein A; Zoffmann S; Meyer CA; Knoflach F; Lugert S; Patsch C; Fjeldskaar F; Chicha-Gaudimier L; Kiialainen A; Piraino P; Bedoucha M; Graf M; Jessberger S; Ghosh A; Bischofberger J; Jagasia R
    Cell Rep; 2016 Apr; 15(1):86-95. PubMed ID: 27052171
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation.
    Alsaqati M; Heine VM; Harwood AJ
    Mol Autism; 2020 Oct; 11(1):80. PubMed ID: 33076974
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex.
    Reith RM; McKenna J; Wu H; Hashmi SS; Cho SH; Dash PK; Gambello MJ
    Neurobiol Dis; 2013 Mar; 51():93-103. PubMed ID: 23123587
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex.
    Winden KD; Pham TT; Teaney NA; Ruiz J; Chen R; Chen C; Sahin M
    Cell Rep; 2023 Aug; 42(8):112838. PubMed ID: 37494191
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.
    Di Nardo A; Kramvis I; Cho N; Sadowski A; Meikle L; Kwiatkowski DJ; Sahin M
    J Neurosci; 2009 May; 29(18):5926-37. PubMed ID: 19420259
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts.
    Dalal JS; Winden KD; Salussolia CL; Sundberg M; Singh A; Pham TT; Zhou P; Pu WT; Miller MT; Sahin M
    Elife; 2021 Jul; 10():. PubMed ID: 34259631
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations.
    Aksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Bhattacharyya S; Wang J; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
    Mol Autism; 2023 Oct; 14(1):39. PubMed ID: 37880800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism.
    Davis PE; Peters JM; Krueger DA; Sahin M
    Neurotherapeutics; 2015 Jul; 12(3):572-83. PubMed ID: 25986747
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biallelic Mutations in
    Winden KD; Sundberg M; Yang C; Wafa SMA; Dwyer S; Chen PF; Buttermore ED; Sahin M
    J Neurosci; 2019 Nov; 39(47):9294-9305. PubMed ID: 31591157
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Restoration of Normal Cerebral Oxygen Consumption with Rapamycin Treatment in a Rat Model of Autism-Tuberous Sclerosis.
    Chi OZ; Wu CC; Liu X; Rah KH; Jacinto E; Weiss HR
    Neuromolecular Med; 2015 Sep; 17(3):305-13. PubMed ID: 26048361
    [TBL] [Abstract][Full Text] [Related]  

  • 14. TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.
    Martin P; Wagh V; Reis SA; Erdin S; Beauchamp RL; Shaikh G; Talkowski M; Thiele E; Sheridan SD; Haggarty SJ; Ramesh V
    Mol Autism; 2020; 11(1):2. PubMed ID: 31921404
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.
    Nie D; Chen Z; Ebrahimi-Fakhari D; Di Nardo A; Julich K; Robson VK; Cheng YC; Woolf CJ; Heiman M; Sahin M
    J Neurosci; 2015 Jul; 35(30):10762-72. PubMed ID: 26224859
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex.
    Li Y; Barkovich MJ; Karch CM; Nillo RM; Fan CC; Broce IJ; Tan CH; Cuneo D; Hess CP; Dillon WP; Glenn OA; Glastonbury CM; Olney N; Yokoyama JS; Bonham LW; Miller B; Kao A; Schmansky N; Fischl B; Andreassen OA; Jernigan T; Dale A; Barkovich AJ; Desikan RS; Sugrue LP
    Sci Rep; 2018 Sep; 8(1):13373. PubMed ID: 30190613
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex.
    Yang F; Yang L; Wataya-Kaneda M; Hasegawa J; Yoshimori T; Tanemura A; Tsuruta D; Katayama I
    J Dermatol Sci; 2018 Feb; 89(2):155-164. PubMed ID: 29146131
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming.
    Armstrong LC; Westlake G; Snow JP; Cawthon B; Armour E; Bowman AB; Ess KC
    Hum Mol Genet; 2017 Dec; 26(23):4629-4641. PubMed ID: 28973543
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca
    Hisatsune C; Shimada T; Miyamoto A; Lee A; Yamagata K
    J Neurosci; 2021 Sep; 41(39):8134-8149. PubMed ID: 34417327
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.
    Mi R; Ma J; Zhang D; Li L; Zhang H
    J Genet Genomics; 2009 Jun; 36(6):355-61. PubMed ID: 19539245
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.