These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

525 related articles for article (PubMed ID: 29457796)

  • 1. H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
    Seiler M; Yoshimi A; Darman R; Chan B; Keaney G; Thomas M; Agrawal AA; Caleb B; Csibi A; Sean E; Fekkes P; Karr C; Klimek V; Lai G; Lee L; Kumar P; Lee SC; Liu X; Mackenzie C; Meeske C; Mizui Y; Padron E; Park E; Pazolli E; Peng S; Prajapati S; Taylor J; Teng T; Wang J; Warmuth M; Yao H; Yu L; Zhu P; Abdel-Wahab O; Smith PG; Buonamici S
    Nat Med; 2018 May; 24(4):497-504. PubMed ID: 29457796
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers.
    Spinello A; Borišek J; Malcovati L; Magistrato A
    Int J Mol Sci; 2021 Oct; 22(20):. PubMed ID: 34681880
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aberrant RNA splicing and therapeutic opportunities in cancers.
    Yamauchi H; Nishimura K; Yoshimi A
    Cancer Sci; 2022 Feb; 113(2):373-381. PubMed ID: 34812550
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Clinicopathologic characterisation of myeloid neoplasms with concurrent spliceosome mutations and myeloproliferative-neoplasm-associated mutations.
    Liu YC; Illar GM; Bailey NG
    J Clin Pathol; 2020 Nov; 73(11):728-736. PubMed ID: 32217616
    [TBL] [Abstract][Full Text] [Related]  

  • 5. [RNA splicing dysregulation in hematological malignancies].
    Yoshida M; Yamauchi H; Sakumoto M; Yoshimi A
    Rinsho Ketsueki; 2023; 64(7):646-653. PubMed ID: 37544725
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
    Finci LI; Zhang X; Huang X; Zhou Q; Tsai J; Teng T; Agrawal A; Chan B; Irwin S; Karr C; Cook A; Zhu P; Reynolds D; Smith PG; Fekkes P; Buonamici S; Larsen NA
    Genes Dev; 2018 Feb; 32(3-4):309-320. PubMed ID: 29491137
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Small-Molecule Splicing Modulator Targets Spliceosome-Mutant Cells.
    Cancer Discov; 2018 Apr; 8(4):384. PubMed ID: 29500297
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
    Hsu TY; Simon LM; Neill NJ; Marcotte R; Sayad A; Bland CS; Echeverria GV; Sun T; Kurley SJ; Tyagi S; Karlin KL; Dominguez-Vidaña R; Hartman JD; Renwick A; Scorsone K; Bernardi RJ; Skinner SO; Jain A; Orellana M; Lagisetti C; Golding I; Jung SY; Neilson JR; Zhang XH; Cooper TA; Webb TR; Neel BG; Shaw CA; Westbrook TF
    Nature; 2015 Sep; 525(7569):384-8. PubMed ID: 26331541
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans.
    Rioux N; Smith S; Colombo F; Kim A; Lai WG; Nix D; Siu YA; Schindler J; Smith PG
    Xenobiotica; 2020 Sep; 50(9):1101-1114. PubMed ID: 31902291
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.
    Aird D; Teng T; Huang CL; Pazolli E; Banka D; Cheung-Ong K; Eifert C; Furman C; Wu ZJ; Seiler M; Buonamici S; Fekkes P; Karr C; Palacino J; Park E; Smith PG; Yu L; Mizui Y; Warmuth M; Chicas A; Corson L; Zhu P
    Nat Commun; 2019 Jan; 10(1):137. PubMed ID: 30635584
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A Comprehensive Overview of Structure-Activity Relationships of Small-Molecule Splicing Modulators Targeting SF3B1 as Anticancer Agents.
    Zhang D; Meng F
    ChemMedChem; 2020 Nov; 15(22):2098-2120. PubMed ID: 33037739
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.
    Lee SC; Dvinge H; Kim E; Cho H; Micol JB; Chung YR; Durham BH; Yoshimi A; Kim YJ; Thomas M; Lobry C; Chen CW; Pastore A; Taylor J; Wang X; Krivtsov A; Armstrong SA; Palacino J; Buonamici S; Smith PG; Bradley RK; Abdel-Wahab O
    Nat Med; 2016 Jun; 22(6):672-8. PubMed ID: 27135740
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Modulating splicing with small molecular inhibitors of the spliceosome.
    Effenberger KA; Urabe VK; Jurica MS
    Wiley Interdiscip Rev RNA; 2017 Mar; 8(2):. PubMed ID: 27440103
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Splicing Factor Mutations in Cancer.
    Bejar R
    Adv Exp Med Biol; 2016; 907():215-28. PubMed ID: 27256388
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome.
    Hong JY; Seo JY; Kim SH; Jung HA; Park S; Kim K; Jung CW; Kim JS; Park JS; Kim HJ; Jang JH
    Anticancer Res; 2015 May; 35(5):3081-9. PubMed ID: 25964599
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Splicing factor mutant myelodysplastic syndromes: Recent advances.
    Pellagatti A; Boultwood J
    Adv Biol Regul; 2020 Jan; 75():100655. PubMed ID: 31558432
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1.
    Zhang J; Ali AM; Lieu YK; Liu Z; Gao J; Rabadan R; Raza A; Mukherjee S; Manley JL
    Mol Cell; 2019 Oct; 76(1):82-95.e7. PubMed ID: 31474574
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dysregulated minor intron splicing in cancer.
    Nishimura K; Yamazaki H; Zang W; Inoue D
    Cancer Sci; 2022 Sep; 113(9):2934-2942. PubMed ID: 35766428
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
    Shirai CL; White BS; Tripathi M; Tapia R; Ley JN; Ndonwi M; Kim S; Shao J; Carver A; Saez B; Fulton RS; Fronick C; O'Laughlin M; Lagisetti C; Webb TR; Graubert TA; Walter MJ
    Nat Commun; 2017 Jan; 8():14060. PubMed ID: 28067246
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting the spliceosome machinery: A new therapeutic axis in cancer?
    Eymin B
    Biochem Pharmacol; 2021 Jul; 189():114039. PubMed ID: 32417188
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.