These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 29474075)

  • 1. Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models.
    Meng Y; Gao C; Clawson DK; Atwell S; Russell M; Vieth M; Roux B
    J Chem Theory Comput; 2018 May; 14(5):2721-2732. PubMed ID: 29474075
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases.
    Lin YL; Roux B
    J Am Chem Soc; 2013 Oct; 135(39):14741-53. PubMed ID: 24001034
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.
    Fabbro D; Manley PW; Jahnke W; Liebetanz J; Szyttenholm A; Fendrich G; Strauss A; Zhang J; Gray NS; Adrian F; Warmuth M; Pelle X; Grotzfeld R; Berst F; Marzinzik A; Cowan-Jacob SW; Furet P; Mestan J
    Biochim Biophys Acta; 2010 Mar; 1804(3):454-62. PubMed ID: 20152788
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.
    Dixit A; Verkhivker GM
    PLoS Comput Biol; 2009 Aug; 5(8):e1000487. PubMed ID: 19714203
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap.
    Corbi-Verge C; Marinelli F; Zafra-Ruano A; Ruiz-Sanz J; Luque I; Faraldo-Gómez JD
    Proc Natl Acad Sci U S A; 2013 Sep; 110(36):E3372-80. PubMed ID: 23959873
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.
    Panjarian S; Iacob RE; Chen S; Wales TE; Engen JR; Smithgall TE
    J Biol Chem; 2013 Mar; 288(9):6116-29. PubMed ID: 23303187
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Probing conformational landscapes and mechanisms of allosteric communication in the functional states of the ABL kinase domain using multiscale simulations and network-based mutational profiling of allosteric residue potentials.
    Krishnan K; Tian H; Tao P; Verkhivker GM
    J Chem Phys; 2022 Dec; 157(24):245101. PubMed ID: 36586979
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Explaining why Gleevec is a specific and potent inhibitor of Abl kinase.
    Lin YL; Meng Y; Jiang W; Roux B
    Proc Natl Acad Sci U S A; 2013 Jan; 110(5):1664-9. PubMed ID: 23319661
    [TBL] [Abstract][Full Text] [Related]  

  • 9. c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution.
    Badger J; Grover P; Shi H; Panjarian SB; Engen JR; Smithgall TE; Makowski L
    Biochemistry; 2016 Jun; 55(23):3251-60. PubMed ID: 27166638
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Computational study of Gleevec and G6G reveals molecular determinants of kinase inhibitor selectivity.
    Lin YL; Meng Y; Huang L; Roux B
    J Am Chem Soc; 2014 Oct; 136(42):14753-62. PubMed ID: 25243930
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Atomistic Modeling of the ABL Kinase Regulation by Allosteric Modulators Using Structural Perturbation Analysis and Community-Based Network Reconstruction of Allosteric Communications.
    Astl L; Verkhivker GM
    J Chem Theory Comput; 2019 May; 15(5):3362-3380. PubMed ID: 31017783
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Integration of a Randomized Sequence Scanning Approach in AlphaFold2 and Local Frustration Profiling of Conformational States Enable Interpretable Atomistic Characterization of Conformational Ensembles and Detection of Hidden Allosteric States in the ABL1 Protein Kinase.
    Raisinghani N; Alshahrani M; Gupta G; Tian H; Xiao S; Tao P; Verkhivker GM
    J Chem Theory Comput; 2024 Jun; 20(12):5317-5336. PubMed ID: 38865109
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Long-time methods for molecular dynamics simulations: Markov State Models and Milestoning.
    Narayan B; Yuan Y; Fathizadeh A; Elber R; Buchete NV
    Prog Mol Biol Transl Sci; 2020; 170():215-237. PubMed ID: 32145946
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Steered molecular dynamics simulations reveal the likelier dissociation pathway of imatinib from its targeting kinases c-Kit and Abl.
    Yang LJ; Zou J; Xie HZ; Li LL; Wei YQ; Yang SY
    PLoS One; 2009 Dec; 4(12):e8470. PubMed ID: 20041122
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.
    Hari SB; Perera BG; Ranjitkar P; Seeliger MA; Maly DJ
    ACS Chem Biol; 2013 Dec; 8(12):2734-43. PubMed ID: 24106839
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Allosteric interactions between the myristate- and ATP-site of the Abl kinase.
    Iacob RE; Zhang J; Gray NS; Engen JR
    PLoS One; 2011 Jan; 6(1):e15929. PubMed ID: 21264348
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of Druggable Kinase Target Conformations Using Markov Model Metastable States Analysis of apo-Abl.
    Paul F; Meng Y; Roux B
    J Chem Theory Comput; 2020 Mar; 16(3):1896-1912. PubMed ID: 31999924
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain.
    Sultan MM; Denny RA; Unwalla R; Lovering F; Pande VS
    Sci Rep; 2017 Nov; 7(1):15604. PubMed ID: 29142210
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Conformational flexibility, binding energy, role of salt bridge and alanine-mutagenesis for c-Abl kinase complex.
    Dubey KD; Ojha RP
    J Mol Model; 2012 May; 18(5):1679-89. PubMed ID: 21811775
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Markov state models provide insights into dynamic modulation of protein function.
    Shukla D; Hernández CX; Weber JK; Pande VS
    Acc Chem Res; 2015 Feb; 48(2):414-22. PubMed ID: 25625937
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.