These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 29485864)

  • 1. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
    Yoshikawa M; Saitoh M; Katoh T; Seki T; Bigi SV; Shimizu Y; Ishii T; Okai T; Kuno M; Hattori H; Watanabe E; Saikatendu KS; Zou H; Nakakariya M; Tatamiya T; Nakada Y; Yogo T
    J Med Chem; 2018 Mar; 61(6):2384-2409. PubMed ID: 29485864
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
    Harris PA; Faucher N; George N; Eidam PM; King BW; White GV; Anderson NA; Bandyopadhyay D; Beal AM; Beneton V; Berger SB; Campobasso N; Campos S; Capriotti CA; Cox JA; Daugan A; Donche F; Fouchet MH; Finger JN; Geddes B; Gough PJ; Grondin P; Hoffman BL; Hoffman SJ; Hutchinson SE; Jeong JU; Jigorel E; Lamoureux P; Leister LK; Lich JD; Mahajan MK; Meslamani J; Mosley JE; Nagilla R; Nassau PM; Ng SL; Ouellette MT; Pasikanti KK; Potvain F; Reilly MA; Rivera EJ; Sautet S; Schaeffer MC; Sehon CA; Sun H; Thorpe JH; Totoritis RD; Ward P; Wellaway N; Wisnoski DD; Woolven JM; Bertin J; Marquis RW
    J Med Chem; 2019 May; 62(10):5096-5110. PubMed ID: 31013427
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors.
    Hamajima T; Takahashi F; Kato K; Mukoyoshi K; Yoshihara K; Yamaki S; Sugano Y; Moritomo A; Yamagami K; Yokoo K; Fukahori H
    Bioorg Med Chem; 2018 May; 26(9):2410-2419. PubMed ID: 29631787
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors.
    Sabat M; Wang H; Scorah N; Lawson JD; Atienza J; Kamran R; Hixon MS; Dougan DR
    Bioorg Med Chem Lett; 2017 May; 27(9):1955-1961. PubMed ID: 28359790
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
    Harris PA; King BW; Bandyopadhyay D; Berger SB; Campobasso N; Capriotti CA; Cox JA; Dare L; Dong X; Finger JN; Grady LC; Hoffman SJ; Jeong JU; Kang J; Kasparcova V; Lakdawala AS; Lehr R; McNulty DE; Nagilla R; Ouellette MT; Pao CS; Rendina AR; Schaeffer MC; Summerfield JD; Swift BA; Totoritis RD; Ward P; Zhang A; Zhang D; Marquis RW; Bertin J; Gough PJ
    J Med Chem; 2016 Mar; 59(5):2163-78. PubMed ID: 26854747
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
    Terao Y; Suzuki H; Yoshikawa M; Yashiro H; Takekawa S; Fujitani Y; Okada K; Inoue Y; Yamamoto Y; Nakagawa H; Yao S; Kawamoto T; Uchikawa O
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7326-9. PubMed ID: 23147077
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.
    Oguro Y; Cary DR; Miyamoto N; Tawada M; Iwata H; Miki H; Hori A; Imamura S
    Bioorg Med Chem; 2013 Aug; 21(15):4714-29. PubMed ID: 23755884
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, Synthesis, and Biological Evaluation of 1-Benzyl-1H-pyrazole Derivatives as Receptor Interacting Protein 1 Kinase Inhibitors.
    Zou C; Xiong Y; Huang LY; Song CL; Wu XA; Li LL; Yang SY
    Chem Biol Drug Des; 2016 Apr; 87(4):569-74. PubMed ID: 26577270
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.
    Zhang L; Zhang B; Zhao J; Zhi Y; Wang L; Lu T; Chen Y
    Eur J Med Chem; 2017 Sep; 138():942-951. PubMed ID: 28755635
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
    Degorce SL; Boyd S; Curwen JO; Ducray R; Halsall CT; Jones CD; Lach F; Lenz EM; Pass M; Pass S; Trigwell C
    J Med Chem; 2016 May; 59(10):4859-66. PubMed ID: 27078757
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells.
    Sun W; Wu X; Gao H; Yu J; Zhao W; Lu JJ; Wang J; Du G; Chen X
    Free Radic Biol Med; 2017 Jul; 108():433-444. PubMed ID: 28414098
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanistic understanding of translational pharmacokinetic-pharmacodynamic relationships in nonclinical tumor models: a case study of orally available novel inhibitors of anaplastic lymphoma kinase.
    Yamazaki S; Lam JL; Zou HY; Wang H; Smeal T; Vicini P
    Drug Metab Dispos; 2015 Jan; 43(1):54-62. PubMed ID: 25349124
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors.
    Wang LX; Liu X; Xu S; Tang Q; Duan Y; Xiao Z; Zhi J; Jiang L; Zheng P; Zhu W
    Eur J Med Chem; 2017 Dec; 141():538-551. PubMed ID: 29107421
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.
    Staben ST; Heffron TP; Sutherlin DP; Bhat SR; Castanedo GM; Chuckowree IS; Dotson J; Folkes AJ; Friedman LS; Lee L; Lesnick J; Lewis C; Murray JM; Nonomiya J; Olivero AG; Plise E; Pang J; Prior WW; Salphati L; Rouge L; Sampath D; Tsui V; Wan NC; Wang S; Weismann C; Wu P; Zhu BY
    Bioorg Med Chem Lett; 2010 Oct; 20(20):6048-51. PubMed ID: 20822905
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.
    Ducray R; Simpson I; Jung FH; Nissink JW; Kenny PW; Fitzek M; Walker GE; Ward LT; Hudson K
    Bioorg Med Chem Lett; 2011 Aug; 21(16):4698-701. PubMed ID: 21775140
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, Docking Study and Kinase Inhibitory Activity of a Number of New Substituted Pyrazolo[3,4-c]pyridines.
    Sklepari M; Lougiakis N; Papastathopoulos A; Pouli N; Marakos P; Myrianthopoulos V; Robert T; Bach S; Mikros E; Ruchaud S
    Chem Pharm Bull (Tokyo); 2017; 65(1):66-81. PubMed ID: 28049917
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors.
    Liu N; Wang Y; Huang G; Ji C; Fan W; Li H; Cheng Y; Tian H
    Bioorg Chem; 2016 Apr; 65():146-58. PubMed ID: 26950400
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
    Green J; Cao J; Bandarage UK; Gao H; Court J; Marhefka C; Jacobs M; Taslimi P; Newsome D; Nakayama T; Shah S; Rodems S
    J Med Chem; 2015 Jun; 58(12):5028-37. PubMed ID: 26039570
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities.
    Xi JB; Fang YF; Frett B; Zhu ML; Zhu T; Kong YN; Guan FJ; Zhao Y; Zhang XW; Li HY; Ma ML; Hu W
    Eur J Med Chem; 2017 Jan; 126():1083-1106. PubMed ID: 28039836
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
    Hayakawa M; Kaizawa H; Kawaguchi K; Ishikawa N; Koizumi T; Ohishi T; Yamano M; Okada M; Ohta M; Tsukamoto S; Raynaud FI; Waterfield MD; Parker P; Workman P
    Bioorg Med Chem; 2007 Jan; 15(1):403-12. PubMed ID: 17049248
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.