211 related articles for article (PubMed ID: 29486616)
1. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4.
Volpi C; Fallarino F; Mondanelli G; Macchiarulo A; Grohmann U
Expert Opin Drug Discov; 2018 May; 13(5):411-423. PubMed ID: 29486616
[TBL] [Abstract][Full Text] [Related]
2. Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders.
CĂ©lanire S; Campo B
Expert Opin Drug Discov; 2012 Mar; 7(3):261-80. PubMed ID: 22468956
[TBL] [Abstract][Full Text] [Related]
3. Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation.
Hellyer S; Leach K; Gregory KJ
Curr Opin Pharmacol; 2017 Feb; 32():49-55. PubMed ID: 27842256
[TBL] [Abstract][Full Text] [Related]
4. Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.
Niswender CM; Jones CK; Lin X; Bubser M; Thompson Gray A; Blobaum AL; Engers DW; Rodriguez AL; Loch MT; Daniels JS; Lindsley CW; Hopkins CR; Javitch JA; Conn PJ
ACS Chem Neurosci; 2016 Sep; 7(9):1201-11. PubMed ID: 27441572
[TBL] [Abstract][Full Text] [Related]
5. Targeting metabotropic glutamate receptors for rapid-acting antidepressant drug discovery.
Musazzi L
Expert Opin Drug Discov; 2021 Feb; 16(2):147-157. PubMed ID: 32962432
[TBL] [Abstract][Full Text] [Related]
6. Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature.
Lindsley CW; Hopkins CR
Expert Opin Ther Pat; 2012 May; 22(5):461-81. PubMed ID: 22506633
[TBL] [Abstract][Full Text] [Related]
7. Chemical biology of mGlu4 receptor activation: dogmas, challenges, strategies and opportunities.
Huang X; Dale E; Brodbeck RM; Doller D
Curr Top Med Chem; 2014; 14(15):1755-70. PubMed ID: 25183417
[TBL] [Abstract][Full Text] [Related]
8. Negative allosteric modulators of group II metabotropic glutamate receptors: A patent review (2015 - present).
Qunies AM; Emmitte KA
Expert Opin Ther Pat; 2021 Aug; 31(8):687-708. PubMed ID: 33719801
[TBL] [Abstract][Full Text] [Related]
9. 4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators.
Jimenez HN; Liu KG; Hong SP; Reitman MS; Uberti MA; Bacolod MD; Cajina M; Nattini M; Sabio M; Doller D
Bioorg Med Chem Lett; 2012 May; 22(9):3235-9. PubMed ID: 22465637
[TBL] [Abstract][Full Text] [Related]
10. Co-operative binding assay for the characterization of mGlu4 allosteric modulators.
Poutiainen P; Kil KE; Zhang Z; Kuruppu D; Tannous B; Brownell AL
Neuropharmacology; 2015 Oct; 97():142-8. PubMed ID: 26025660
[TBL] [Abstract][Full Text] [Related]
11. Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.
Bennett KA; Christopher JA; Tehan BG
Adv Pharmacol; 2020; 88():35-58. PubMed ID: 32416871
[TBL] [Abstract][Full Text] [Related]
12. Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders.
Gregory KJ; Noetzel MJ; Niswender CM
Prog Mol Biol Transl Sci; 2013; 115():61-121. PubMed ID: 23415092
[TBL] [Abstract][Full Text] [Related]
13. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.
Gogliotti RD; Engers DW; Garcia-Barrantes PM; Panarese JD; Gentry PR; Blobaum AL; Morrison RD; Daniels JS; Thompson AD; Jones CK; Conn PJ; Niswender CM; Lindsley CW; Hopkins CR
Bioorg Med Chem Lett; 2016 Jun; 26(12):2915-2919. PubMed ID: 27131990
[TBL] [Abstract][Full Text] [Related]
14. The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu
Panarese JD; Engers DW; Wu YJ; Guernon JM; Chun A; Gregro AR; Bender AM; Capstick RA; Wieting JM; Bronson JJ; Macor JE; Westphal R; Soars M; Engers JE; Felts AS; Rodriguez AL; Emmitte KA; Jones CK; Blobaum AL; Conn PJ; Niswender CM; Hopkins CR; Lindsley CW
Bioorg Med Chem Lett; 2019 Jan; 29(2):342-346. PubMed ID: 30503632
[TBL] [Abstract][Full Text] [Related]
15. Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action.
Gubellini P; Melon C; Dale E; Doller D; Kerkerian-Le Goff L
Neuropharmacology; 2014 Oct; 85():166-77. PubMed ID: 24866785
[TBL] [Abstract][Full Text] [Related]
16. mGluR2 positive allosteric modulators: a patent review (2009 - present).
Trabanco AA; Cid JM
Expert Opin Ther Pat; 2013 May; 23(5):629-47. PubMed ID: 23452205
[TBL] [Abstract][Full Text] [Related]
17. Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics.
Robichaud AJ; Engers DW; Lindsley CW; Hopkins CR
ACS Chem Neurosci; 2011 Aug; 2(8):433-49. PubMed ID: 22860170
[TBL] [Abstract][Full Text] [Related]
18. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.
Hong SP; Liu KG; Ma G; Sabio M; Uberti MA; Bacolod MD; Peterson J; Zou ZZ; Robichaud AJ; Doller D
J Med Chem; 2011 Jul; 54(14):5070-81. PubMed ID: 21688779
[TBL] [Abstract][Full Text] [Related]
19. Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).
Celanire S; Sebhat I; Wichmann J; Mayer S; Schann S; Gatti S
Expert Opin Ther Pat; 2015 Jan; 25(1):69-90. PubMed ID: 25435285
[TBL] [Abstract][Full Text] [Related]
20. Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.
Felts AS; Rodriguez AL; Smith KA; Engers JL; Morrison RD; Byers FW; Blobaum AL; Locuson CW; Chang S; Venable DF; Niswender CM; Daniels JS; Conn PJ; Lindsley CW; Emmitte KA
J Med Chem; 2015 Nov; 58(22):9027-40. PubMed ID: 26524606
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]