BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

223 related articles for article (PubMed ID: 29507187)

  • 1. Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells.
    Kuuluvainen E; Domènech-Moreno E; Niemelä EH; Mäkelä TP
    Mol Cell Biol; 2018 Jun; 38(11):. PubMed ID: 29507187
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
    J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.
    Kuuluvainen E; Hakala H; Havula E; Sahal Estimé M; Rämet M; Hietakangas V; Mäkelä TP
    J Biol Chem; 2014 Jun; 289(23):16252-61. PubMed ID: 24778181
    [TBL] [Abstract][Full Text] [Related]  

  • 4. MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.
    Sooraj D; Sun C; Doan A; Garama DJ; Dannappel MV; Zhu D; Chua HK; Mahara S; Wan Hassan WA; Tay YK; Guanizo A; Croagh D; Prodanovic Z; Gough DJ; Wan C; Firestein R
    Mol Cell; 2022 Jan; 82(1):123-139.e7. PubMed ID: 34910943
    [TBL] [Abstract][Full Text] [Related]  

  • 5. De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.
    Calpena E; Hervieu A; Kaserer T; Swagemakers SMA; Goos JAC; Popoola O; Ortiz-Ruiz MJ; Barbaro-Dieber T; Bownass L; Brilstra EH; Brimble E; Foulds N; Grebe TA; Harder AVE; Lees MM; Monaghan KG; Newbury-Ecob RA; Ong KR; Osio D; Reynoso Santos FJ; Ruzhnikov MRZ; Telegrafi A; van Binsbergen E; van Dooren MF; ; van der Spek PJ; Blagg J; Twigg SRF; Mathijssen IMJ; Clarke PA; Wilkie AOM
    Am J Hum Genet; 2019 Apr; 104(4):709-720. PubMed ID: 30905399
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas.
    Mäkinen N; Heinonen HR; Sjöberg J; Taipale J; Vahteristo P; Aaltonen LA
    Br J Cancer; 2014 Apr; 110(9):2246-9. PubMed ID: 24642626
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Distinct effects of CDK8 module subunits on cellular growth and proliferation in
    Li X; Liu M; Xing Y; Niu Y; Liu TH; Sun JL; Liu Y; Hemba-Waduge RU; Ji JY
    bioRxiv; 2024 May; ():. PubMed ID: 38746212
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
    Kämpjärvi K; Kim NH; Keskitalo S; Clark AD; von Nandelstadh P; Turunen M; Heikkinen T; Park MJ; Mäkinen N; Kivinummi K; Lintula S; Hotakainen K; Nevanlinna H; Hokland P; Böhling T; Bützow R; Böhm J; Mecklin JP; Järvinen H; Kontro M; Visakorpi T; Taipale J; Varjosalo M; Boyer TG; Vahteristo P
    Prostate; 2016 Jan; 76(1):22-31. PubMed ID: 26383637
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
    Klatt F; Leitner A; Kim IV; Ho-Xuan H; Schneider EV; Langhammer F; Weinmann R; Müller MR; Huber R; Meister G; Kuhn CD
    Proc Natl Acad Sci U S A; 2020 Feb; 117(6):2894-2905. PubMed ID: 31988137
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
    Gobert V; Osman D; Bras S; Augé B; Boube M; Bourbon HM; Horn T; Boutros M; Haenlin M; Waltzer L
    Mol Cell Biol; 2010 Jun; 30(11):2837-48. PubMed ID: 20368357
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer.
    Voutsadakis IA
    Pharmacol Rep; 2024 Jun; 76(3):535-556. PubMed ID: 38602606
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.
    Broude EV; Győrffy B; Chumanevich AA; Chen M; McDermott MS; Shtutman M; Catroppo JF; Roninson IB
    Curr Cancer Drug Targets; 2015; 15(8):739-49. PubMed ID: 26452386
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulatory functions of the Mediator kinases CDK8 and CDK19.
    Fant CB; Taatjes DJ
    Transcription; 2019 Apr; 10(2):76-90. PubMed ID: 30585107
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.
    Davis MA; Larimore EA; Fissel BM; Swanger J; Taatjes DJ; Clurman BE
    Genes Dev; 2013 Jan; 27(2):151-6. PubMed ID: 23322298
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
    Turunen M; Spaeth JM; Keskitalo S; Park MJ; Kivioja T; Clark AD; Mäkinen N; Gao F; Palin K; Nurkkala H; Vähärautio A; Aavikko M; Kämpjärvi K; Vahteristo P; Kim CA; Aaltonen LA; Varjosalo M; Taipale J; Boyer TG
    Cell Rep; 2014 May; 7(3):654-60. PubMed ID: 24746821
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation.
    Papadopoulou T; Kaymak A; Sayols S; Richly H
    Cell Cycle; 2016 Jun; 15(11):1479-93. PubMed ID: 27096886
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.
    Knuesel MT; Meyer KD; Bernecky C; Taatjes DJ
    Genes Dev; 2009 Feb; 23(4):439-51. PubMed ID: 19240132
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Mediator kinase module: an interface between cell signaling and transcription.
    Luyties O; Taatjes DJ
    Trends Biochem Sci; 2022 Apr; 47(4):314-327. PubMed ID: 35193797
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A complex molecular switch directs stress-induced cyclin C nuclear release through SCF
    Stieg DC; Willis SD; Ganesan V; Ong KL; Scuorzo J; Song M; Grose J; Strich R; Cooper KF
    Mol Biol Cell; 2018 Feb; 29(3):363-375. PubMed ID: 29212878
    [TBL] [Abstract][Full Text] [Related]  

  • 20. MED12 interacts with the heat-shock transcription factor HSF1 and recruits CDK8 to promote the heat-shock response in mammalian cells.
    Srivastava P; Takii R; Okada M; Fujimoto M; Nakai A
    FEBS Lett; 2021 Jul; 595(14):1933-1948. PubMed ID: 34056708
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.