These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

241 related articles for article (PubMed ID: 29510038)

  • 1. Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
    Kono M; Ochida A; Oda T; Imada T; Banno Y; Taya N; Masada S; Kawamoto T; Yonemori K; Nara Y; Fukase Y; Yukawa T; Tokuhara H; Skene R; Sang BC; Hoffman ID; Snell GP; Uga K; Shibata A; Igaki K; Nakamura Y; Nakagawa H; Tsuchimori N; Yamasaki M; Shirai J; Yamamoto S
    J Med Chem; 2018 Apr; 61(7):2973-2988. PubMed ID: 29510038
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist.
    Shibata A; Uga K; Sato T; Sagara M; Igaki K; Nakamura Y; Ochida A; Kono M; Shirai J; Yamamoto S; Yamasaki M; Tsuchimori N
    Biochem Pharmacol; 2018 Apr; 150():35-45. PubMed ID: 29369782
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.
    Kono M; Oda T; Tawada M; Imada T; Banno Y; Taya N; Kawamoto T; Tokuhara H; Tomata Y; Ishii N; Ochida A; Fukase Y; Yukawa T; Fukumoto S; Watanabe H; Uga K; Shibata A; Nakagawa H; Shirasaki M; Fujitani Y; Yamasaki M; Shirai J; Yamamoto S
    Bioorg Med Chem; 2018 Jan; 26(2):470-482. PubMed ID: 29258712
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of 2H-chromone-4-one based sulfonamide derivatives as potent retinoic acid receptor-related orphan receptor γt inverse agonists.
    Chen L; Su M; Wu XZ; Wang DZ; Kang YY; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Jin Q; Huang RZ; Liao ZX
    Eur J Med Chem; 2022 Feb; 229():114065. PubMed ID: 34971876
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists.
    Lu L; Chen S; Yu M; Zhou R; Guo S; Chen JA; Wang H; Chen S; Luo C; Xie Q; Wang Y
    Eur J Med Chem; 2023 Aug; 256():115424. PubMed ID: 37167779
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model.
    Igaki K; Nakamura Y; Komoike Y; Uga K; Shibata A; Ishimura Y; Yamasaki M; Tsukimi Y; Tsuchimori N
    Inflammation; 2019 Feb; 42(1):91-102. PubMed ID: 30121880
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of novel quinazolinedione derivatives as RORγt inverse agonist.
    Fukase Y; Sato A; Tomata Y; Ochida A; Kono M; Yonemori K; Koga K; Okui T; Yamasaki M; Fujitani Y; Nakagawa H; Koyama R; Nakayama M; Skene R; Sang BC; Hoffman I; Shirai J; Yamamoto S
    Bioorg Med Chem; 2018 Feb; 26(3):721-736. PubMed ID: 29342416
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
    Chen L; Su M; Jin Q; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Liao ZX
    Bioorg Chem; 2022 Feb; 119():105483. PubMed ID: 34906860
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.
    Fauber BP; René O; Deng Y; DeVoss J; Eidenschenk C; Everett C; Ganguli A; Gobbi A; Hawkins J; Johnson AR; La H; Lesch J; Lockey P; Norman M; Ouyang W; Summerhill S; Wong H
    J Med Chem; 2015 Jul; 58(13):5308-22. PubMed ID: 26061388
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacological evaluation of TAK-828F, a novel orally available RORγt inverse agonist, on murine chronic experimental autoimmune encephalomyelitis model.
    Nakamura Y; Igaki K; Uga K; Shibata A; Yamauchi H; Yamasaki M; Tsuchimori N
    J Neuroimmunol; 2019 Oct; 335():577016. PubMed ID: 31374381
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists.
    Hintermann S; Guntermann C; Mattes H; Carcache DA; Wagner J; Vulpetti A; Billich A; Dawson J; Kaupmann K; Kallen J; Stringer R; Orain D
    ChemMedChem; 2016 Dec; 11(24):2640-2648. PubMed ID: 27902884
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
    Schnute ME; Wennerstål M; Alley J; Bengtsson M; Blinn JR; Bolten CW; Braden T; Bonn T; Carlsson B; Caspers N; Chen M; Choi C; Collis LP; Crouse K; Färnegårdh M; Fennell KF; Fish S; Flick AC; Goos-Nilsson A; Gullberg H; Harris PK; Heasley SE; Hegen M; Hromockyj AE; Hu X; Husman B; Janosik T; Jones P; Kaila N; Kallin E; Kauppi B; Kiefer JR; Knafels J; Koehler K; Kruger L; Kurumbail RG; Kyne RE; Li W; Löfstedt J; Long SA; Menard CA; Mente S; Messing D; Meyers MJ; Napierata L; Nöteberg D; Nuhant P; Pelc MJ; Prinsen MJ; Rhönnstad P; Backström-Rydin E; Sandberg J; Sandström M; Shah F; Sjöberg M; Sundell A; Taylor AP; Thorarensen A; Trujillo JI; Trzupek JD; Unwalla R; Vajdos FF; Weinberg RA; Wood DC; Xing L; Zamaratski E; Zapf CW; Zhao Y; Wilhelmsson A; Berstein G
    J Med Chem; 2018 Dec; 61(23):10415-10439. PubMed ID: 30130103
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-Based Design and Synthesis of Fluorene Derivatives as Novel RORγt Inverse Agonists.
    Gabr MT; Abdel-Raziq MS
    Chem Biodivers; 2018 Sep; 15(9):e1800244. PubMed ID: 29935095
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of N-indanyl benzamides as potent RORγt inverse agonists.
    Tian J; Sun N; Yu M; Gu X; Xie Q; Shao L; Liu J; Liu L; Wang Y
    Eur J Med Chem; 2019 Apr; 167():37-48. PubMed ID: 30743096
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases.
    Sun N; Ma X; Zhou K; Zhu C; Cao Z; Wang Y; Xu J; Fu W
    Eur J Med Chem; 2020 Feb; 187():111984. PubMed ID: 31881455
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists.
    Wu XS; Wang R; Xing YL; Xue XQ; Zhang Y; Lu YZ; Song Y; Luo XY; Wu C; Zhou YL; Jiang JQ; Xu Y
    Acta Pharmacol Sin; 2016 Nov; 37(11):1516-1524. PubMed ID: 27374490
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.
    Shirai J; Tomata Y; Kono M; Ochida A; Fukase Y; Sato A; Masada S; Kawamoto T; Yonemori K; Koyama R; Nakagawa H; Nakayama M; Uga K; Shibata A; Koga K; Okui T; Shirasaki M; Skene R; Sang B; Hoffman I; Lane W; Fujitani Y; Yamasaki M; Yamamoto S
    Bioorg Med Chem; 2018 Jan; 26(2):483-500. PubMed ID: 29262987
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease.
    Igaki K; Nakamura Y; Tanaka M; Mizuno S; Yoshimatsu Y; Komoike Y; Uga K; Shibata A; Imaichi H; Takayuki S; Ishimura Y; Yamasaki M; Kanai T; Tsukimi Y; Tsuchimori N
    Inflamm Res; 2019 Jun; 68(6):493-509. PubMed ID: 30972425
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
    Chen L; Su M; Jin Q; Wang W; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Liao ZX
    J Med Chem; 2021 Nov; 64(21):16106-16131. PubMed ID: 34723528
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.
    Gege C; Schlüter T; Hoffmann T
    Bioorg Med Chem Lett; 2014 Nov; 24(22):5265-7. PubMed ID: 25305688
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.