BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 29524278)

  • 1. p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction.
    Medina-Medina I; Martínez-Sánchez M; Hernández-Monge J; Fahraeus R; Muller P; Olivares-Illana V
    Protein Sci; 2018 May; 27(5):976-986. PubMed ID: 29524278
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions.
    Medina-Medina I; García-Beltrán P; de la Mora-de la Mora I; Oria-Hernández J; Millot G; Fahraeus R; Reyes-Vivas H; Sampedro JG; Olivares-Illana V
    Mol Cell Biol; 2016 Aug; 36(16):2195-205. PubMed ID: 27215386
    [TBL] [Abstract][Full Text] [Related]  

  • 3. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.
    Linares LK; Hengstermann A; Ciechanover A; Müller S; Scheffner M
    Proc Natl Acad Sci U S A; 2003 Oct; 100(21):12009-14. PubMed ID: 14507994
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3.
    Patton JT; Mayo LD; Singhi AD; Gudkov AV; Stark GR; Jackson MW
    Cancer Res; 2006 Mar; 66(6):3169-76. PubMed ID: 16540668
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A stapled p53 helix overcomes HDMX-mediated suppression of p53.
    Bernal F; Wade M; Godes M; Davis TN; Whitehead DG; Kung AL; Wahl GM; Walensky LD
    Cancer Cell; 2010 Nov; 18(5):411-22. PubMed ID: 21075307
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.
    Meulmeester E; Maurice MM; Boutell C; Teunisse AF; Ovaa H; Abraham TE; Dirks RW; Jochemsen AG
    Mol Cell; 2005 May; 18(5):565-76. PubMed ID: 15916963
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism.
    Calderon-González KG; Medina-Medina I; Haronikova L; Hernychova L; Bonczek O; Uhrik L; Hrabal V; Vojtesek B; Fahraeus R; Hernández-Monge J; Olivares-Illana V
    Biosci Rep; 2022 Jul; 42(7):. PubMed ID: 35674210
    [TBL] [Abstract][Full Text] [Related]  

  • 8. HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.
    Phillips A; Teunisse A; Lam S; Lodder K; Darley M; Emaduddin M; Wolf A; Richter J; de Lange J; Verlaan-de Vries M; Lenos K; Böhnke A; Bartel F; Blaydes JP; Jochemsen AG
    J Biol Chem; 2010 Sep; 285(38):29111-27. PubMed ID: 20659896
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes.
    Kallen J; Goepfert A; Blechschmidt A; Izaac A; Geiser M; Tavares G; Ramage P; Furet P; Masuya K; Lisztwan J
    J Biol Chem; 2009 Mar; 284(13):8812-21. PubMed ID: 19153082
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation.
    Migliorini D; Danovi D; Colombo E; Carbone R; Pelicci PG; Marine JC
    J Biol Chem; 2002 Mar; 277(9):7318-23. PubMed ID: 11744695
    [TBL] [Abstract][Full Text] [Related]  

  • 11. HDM2 and HDMX Proteins in Human Cancer.
    Hároníková L; Vojtěšek B
    Klin Onkol; 2018; 31(Suppl 2):63-70. PubMed ID: 31023026
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.
    de Graaf P; Little NA; Ramos YF; Meulmeester E; Letteboer SJ; Jochemsen AG
    J Biol Chem; 2003 Oct; 278(40):38315-24. PubMed ID: 12874296
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.
    Giglio S; Mancini F; Gentiletti F; Sparaco G; Felicioni L; Barassi F; Martella C; Prodosmo A; Iacovelli S; Buttitta F; Farsetti A; Soddu S; Marchetti A; Sacchi A; Pontecorvi A; Moretti F
    Cancer Res; 2005 Nov; 65(21):9687-94. PubMed ID: 16266988
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hdmx modulates the outcome of p53 activation in human tumor cells.
    Wade M; Wong ET; Tang M; Stommel JM; Wahl GM
    J Biol Chem; 2006 Nov; 281(44):33036-44. PubMed ID: 16905769
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.
    Sarkari F; La Delfa A; Arrowsmith CH; Frappier L; Sheng Y; Saridakis V
    J Mol Biol; 2010 Oct; 402(5):825-37. PubMed ID: 20713061
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of a Structural Determinant for Selective Targeting of HDMX.
    Ben-Nun Y; Seo HS; Harvey EP; Hauseman ZJ; Wales TE; Newman CE; Cathcart AM; Engen JR; Dhe-Paganon S; Walensky LD
    Structure; 2020 Jul; 28(7):847-857.e5. PubMed ID: 32359398
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hdmx stabilizes Mdm2 and p53.
    Stad R; Ramos YF; Little N; Grivell S; Attema J; van Der Eb AJ; Jochemsen AG
    J Biol Chem; 2000 Sep; 275(36):28039-44. PubMed ID: 10827196
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study.
    Srdanović S; Wolter M; Trinh CH; Ottmann C; Warriner SL; Wilson AJ
    FEBS J; 2022 Sep; 289(17):5341-5358. PubMed ID: 35286747
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Beta-peptides with improved affinity for hDM2 and hDMX.
    Harker EA; Daniels DS; Guarracino DA; Schepartz A
    Bioorg Med Chem; 2009 Mar; 17(5):2038-46. PubMed ID: 19211253
    [TBL] [Abstract][Full Text] [Related]  

  • 20. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.
    Lau LM; Nugent JK; Zhao X; Irwin MS
    Oncogene; 2008 Feb; 27(7):997-1003. PubMed ID: 17700533
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.