190 related articles for article (PubMed ID: 29547693)
1. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
Hammill JT; Bhasin D; Scott DC; Min J; Chen Y; Lu Y; Yang L; Kim HS; Connelly MC; Hammill C; Holbrook G; Jeffries C; Singh B; Schulman BA; Guy RK
J Med Chem; 2018 Apr; 61(7):2694-2706. PubMed ID: 29547693
[TBL] [Abstract][Full Text] [Related]
2. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
Hammill JT; Scott DC; Min J; Connelly MC; Holbrook G; Zhu F; Matheny A; Yang L; Singh B; Schulman BA; Guy RK
J Med Chem; 2018 Apr; 61(7):2680-2693. PubMed ID: 29547696
[TBL] [Abstract][Full Text] [Related]
3. Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
Kim HS; Hammill JT; Scott DC; Chen Y; Min J; Rector J; Singh B; Schulman BA; Guy RK
J Med Chem; 2019 Sep; 62(18):8429-8442. PubMed ID: 31465221
[TBL] [Abstract][Full Text] [Related]
4. Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway.
Zhou H; Lu J; Yang CY; Sun Y; Wang S
Adv Exp Med Biol; 2020; 1217():349-362. PubMed ID: 31898237
[TBL] [Abstract][Full Text] [Related]
5. Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M.
Kim HS; Hammill JT; Scott DC; Chen Y; Rice AL; Pistel W; Singh B; Schulman BA; Guy RK
J Med Chem; 2021 May; 64(9):5850-5862. PubMed ID: 33945681
[TBL] [Abstract][Full Text] [Related]
6. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.
Zhou H; Lu J; Liu L; Bernard D; Yang CY; Fernandez-Salas E; Chinnaswamy K; Layton S; Stuckey J; Yu Q; Zhou W; Pan Z; Sun Y; Wang S
Nat Commun; 2017 Oct; 8(1):1150. PubMed ID: 29074978
[TBL] [Abstract][Full Text] [Related]
7. Targeting neddylation E2s: a novel therapeutic strategy in cancer.
Zheng YC; Guo YJ; Wang B; Wang C; Mamun MAA; Gao Y; Liu HM
J Hematol Oncol; 2021 Apr; 14(1):57. PubMed ID: 33827629
[TBL] [Abstract][Full Text] [Related]
8. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
He ZX; An Q; Wei B; Zhou WJ; Wei BF; Gong YP; Zhang X; Gao G; Dong GJ; Huo JL; Zhang XH; Yang FF; Liu HM; Ma LY; Zhao W
J Med Chem; 2022 Jan; 65(1):163-190. PubMed ID: 34939411
[TBL] [Abstract][Full Text] [Related]
9. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.
Zhou H; Zhou W; Zhou B; Liu L; Chern TR; Chinnaswamy K; Lu J; Bernard D; Yang CY; Li S; Wang M; Stuckey J; Sun Y; Wang S
J Med Chem; 2018 Mar; 61(5):1934-1950. PubMed ID: 29438612
[TBL] [Abstract][Full Text] [Related]
10. Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Zhou W; Ma L; Ding L; Guo Q; He Z; Yang J; Qiao H; Li L; Yang J; Yu S; Zhao L; Wang S; Liu HM; Suo Z; Zhao W
J Med Chem; 2019 Jun; 62(11):5382-5403. PubMed ID: 31157974
[TBL] [Abstract][Full Text] [Related]
11. Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Zhou W; Xu C; Dong G; Qiao H; Yang J; Liu H; Ding L; Sun K; Zhao W
Eur J Med Chem; 2021 May; 217():113326. PubMed ID: 33756127
[TBL] [Abstract][Full Text] [Related]
12. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Meyer-Schaller N; Chou YC; Sumara I; Martin DD; Kurz T; Katheder N; Hofmann K; Berthiaume LG; Sicheri F; Peter M
Proc Natl Acad Sci U S A; 2009 Jul; 106(30):12365-70. PubMed ID: 19617556
[TBL] [Abstract][Full Text] [Related]
13. Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer.
Li L; Kang J; Zhang W; Cai L; Wang S; Liang Y; Jiang Y; Liu X; Zhang Y; Ruan H; Chen G; Wang M; Jia L
EBioMedicine; 2019 Jul; 45():81-91. PubMed ID: 31208947
[TBL] [Abstract][Full Text] [Related]
14. Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation.
Kurz T; Chou YC; Willems AR; Meyer-Schaller N; Hecht ML; Tyers M; Peter M; Sicheri F
Mol Cell; 2008 Jan; 29(1):23-35. PubMed ID: 18206966
[TBL] [Abstract][Full Text] [Related]
15. Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.
Zhou H; Lu J; Chinnaswamy K; Stuckey JA; Liu L; McEachern D; Yang CY; Bernard D; Shen H; Rui L; Sun Y; Wang S
Nat Commun; 2021 May; 12(1):2621. PubMed ID: 33976147
[TBL] [Abstract][Full Text] [Related]
16. NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Zhao X; Jiang L; Hu D; Tang Y; Zhao G; Du X; Luo S; Tang W
Exp Cell Res; 2021 Jun; 403(2):112614. PubMed ID: 33905671
[TBL] [Abstract][Full Text] [Related]
17. Pharmaceutical Inhibition of Neddylation as Promising Treatments for Various Cancers.
Yin L; Xue Y; Shang Q; Zhu H; Liu M; Liu Y; Hu Q
Curr Top Med Chem; 2019; 19(12):1059-1069. PubMed ID: 30854973
[TBL] [Abstract][Full Text] [Related]
18. Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
Zhou W; Dong G; Gao G; He Z; Xu J; Aziz S; Ma L; Zhao W
Biochem Cell Biol; 2022 Aug; 100(4):309-324. PubMed ID: 35544948
[TBL] [Abstract][Full Text] [Related]
19. Overactivated neddylation pathway as a therapeutic target in lung cancer.
Li L; Wang M; Yu G; Chen P; Li H; Wei D; Zhu J; Xie L; Jia H; Shi J; Li C; Yao W; Wang Y; Gao Q; Jeong LS; Lee HW; Yu J; Hu F; Mei J; Wang P; Chu Y; Qi H; Yang M; Dong Z; Sun Y; Hoffman RM; Jia L
J Natl Cancer Inst; 2014 Jun; 106(6):dju083. PubMed ID: 24853380
[TBL] [Abstract][Full Text] [Related]
20. A tobacco homolog of DCN1 is involved in pollen development and embryogenesis.
Hosp J; Ribarits A; Retzer K; Jin Y; Tashpulatov A; Resch T; Friedmann C; Ankele E; Voronin V; Palme K; Heberle-Bors E; Touraev A
Plant Cell Rep; 2014 Jul; 33(7):1187-202. PubMed ID: 24748527
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
