BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 29573040)

  • 21. A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data.
    Jonker DM; Kenna LA; Leishman D; Wallis R; Milligan PA; Jonsson EN
    Clin Pharmacol Ther; 2005 Jun; 77(6):572-82. PubMed ID: 15961988
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide.
    Carvalho JF; Louvel J; Doornbos ML; Klaasse E; Yu Z; Brussee J; IJzerman AP
    J Med Chem; 2013 Apr; 56(7):2828-40. PubMed ID: 23473309
    [TBL] [Abstract][Full Text] [Related]  

  • 23. NS1643 enhances ionic currents in a G604S-WT hERG co-expression system associated with long QT syndrome 2.
    Huo J; Guo X; Lu Q; Qiang H; Liu P; Bai L; Huang CL; Zhang Y; Ma A
    Clin Exp Pharmacol Physiol; 2017 Nov; 44(11):1125-1133. PubMed ID: 28741726
    [TBL] [Abstract][Full Text] [Related]  

  • 24. L539 fs/47, a truncated mutation of human ether-a-go-go-related gene (hERG), decreases hERG ion channel currents in HEK 293 cells.
    Zhang A; Sun C; Zhang L; Lv Y; Xue X; Li G; Cui C; Yan GX
    Clin Exp Pharmacol Physiol; 2013 Jan; 40(1):28-36. PubMed ID: 23134353
    [TBL] [Abstract][Full Text] [Related]  

  • 25. [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?
    Finlayson K; Pennington AJ; Kelly JS
    Eur J Pharmacol; 2001 Feb; 412(3):203-12. PubMed ID: 11166283
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
    Potet F; Lorinc AN; Chaigne S; Hopkins CR; Venkataraman R; Stepanovic SZ; Lewis LM; Days E; Sidorov VY; Engers DW; Zou B; Afshartous D; George AL; Campbell CM; Balser JR; Li M; Baudenbacher FJ; Lindsley CW; Weaver CD; Kupershmidt S
    J Biol Chem; 2012 Nov; 287(47):39613-25. PubMed ID: 23033485
    [TBL] [Abstract][Full Text] [Related]  

  • 27. RNA interference targeting E637K mutation rescues hERG channel currents and restores its kinetic properties.
    Lu X; Yang X; Huang X; Huang C; Sun HH; Jin L; Xu W; Mao H; Guo J; Zhou J; Lian J
    Heart Rhythm; 2013 Jan; 10(1):128-36. PubMed ID: 23022675
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
    Davie C; Pierre-Valentin J; Pollard C; Standen N; Mitcheson J; Alexander P; Thong B
    J Cardiovasc Electrophysiol; 2004 Nov; 15(11):1302-9. PubMed ID: 15574182
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Pharmacological corrections of the mutant hERG channels by posaconazole.
    Luo C; Zheng X; Li J; Zhang Y; Shi T; Yan Y; Han D
    Clin Exp Pharmacol Physiol; 2021 Jun; 48(6):855-868. PubMed ID: 33631842
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Identification and functional characterization of the human ether-a-go-go-related gene Q738X mutant associated with hereditary long QT syndrome type 2.
    Han SN; Yang SH; Zhang Y; Sun XY; Duan YY; Hu XJ; Fan TL; Huang CZ; Yang G; Zhang Z; Zhang L
    Int J Mol Med; 2014 Sep; 34(3):810-5. PubMed ID: 24993425
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A trafficking-deficient KCNQ1 mutation, T587M, causes a severe phenotype of long QT syndrome by interfering with intracellular hERG transport.
    Wu J; Sakaguchi T; Takenaka K; Toyoda F; Tsuji K; Matsuura H; Horie M
    J Cardiol; 2019 May; 73(5):343-350. PubMed ID: 30591322
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes.
    Lin EC; Holzem KM; Anson BD; Moungey BM; Balijepalli SY; Tester DJ; Ackerman MJ; Delisle BP; Balijepalli RC; January CT
    Am J Physiol Heart Circ Physiol; 2010 Jun; 298(6):H1842-9. PubMed ID: 20363883
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Early LQT2 nonsense mutation generates N-terminally truncated hERG channels with altered gating properties by the reinitiation of translation.
    Stump MR; Gong Q; Packer JD; Zhou Z
    J Mol Cell Cardiol; 2012 Nov; 53(5):725-33. PubMed ID: 22964610
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Allosteric modulators of the hERG K(+) channel: radioligand binding assays reveal allosteric characteristics of dofetilide analogs.
    Yu Z; Klaasse E; Heitman LH; Ijzerman AP
    Toxicol Appl Pharmacol; 2014 Jan; 274(1):78-86. PubMed ID: 24200993
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.
    Ishii K; Nagai M; Takahashi M; Endoh M
    Cardiovasc Res; 2003 Mar; 57(3):651-9. PubMed ID: 12618227
    [TBL] [Abstract][Full Text] [Related]  

  • 36. The EGFP/hERG fusion protein alter the electrophysiological properties of hERG channels in HEK293 cells.
    Huang N; Lian JF; Huo JH; Liu LY; Ni L; Yang X; Zhou JQ; Li ZF; Song TS; Huang C
    Cell Biol Int; 2011 Mar; 35(3):193-9. PubMed ID: 21143190
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil.
    Vicente J; Johannesen L; Mason JW; Crumb WJ; Pueyo E; Stockbridge N; Strauss DG
    J Am Heart Assoc; 2015 Apr; 4(4):. PubMed ID: 25870186
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The long QT syndrome: new diagnostic and therapeutic approach in the era of molecular biology.
    Priori SG; Cantù F; Schwartz PJ
    Schweiz Med Wochenschr; 1996 Oct; 126(41):1727-31. PubMed ID: 8893413
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation.
    Saxena P; Hortigon-Vinagre MP; Beyl S; Baburin I; Andranovits S; Iqbal SM; Costa A; IJzerman AP; Kügler P; Timin E; Smith GL; Hering S
    Br J Pharmacol; 2017 Sep; 174(18):3081-3093. PubMed ID: 28681507
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Tbx20 controls the expression of the KCNH2 gene and of hERG channels.
    Caballero R; Utrilla RG; Amorós I; Matamoros M; Pérez-Hernández M; Tinaquero D; Alfayate S; Nieto-Marín P; Guerrero-Serna G; Liu QH; Ramos-Mondragón R; Ponce-Balbuena D; Herron T; Campbell KF; Filgueiras-Rama D; Peinado R; López-Sendón JL; Jalife J; Delpón E; Tamargo J
    Proc Natl Acad Sci U S A; 2017 Jan; 114(3):E416-E425. PubMed ID: 28049825
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.