BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 29602039)

  • 1. Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.
    Pippione AC; Carnovale IM; Bonanni D; Sini M; Goyal P; Marini E; Pors K; Adinolfi S; Zonari D; Festuccia C; Wahlgren WY; Friemann R; Bagnati R; Boschi D; Oliaro-Bosso S; Lolli ML
    Eur J Med Chem; 2018 Apr; 150():930-945. PubMed ID: 29602039
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.
    Pippione AC; Giraudo A; Bonanni D; Carnovale IM; Marini E; Cena C; Costale A; Zonari D; Pors K; Sadiq M; Boschi D; Oliaro-Bosso S; Lolli ML
    Eur J Med Chem; 2017 Oct; 139():936-946. PubMed ID: 28881288
    [TBL] [Abstract][Full Text] [Related]  

  • 3. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold.
    Pippione AC; Kilic-Kurt Z; Kovachka S; Sainas S; Rolando B; Denasio E; Pors K; Adinolfi S; Zonari D; Bagnati R; Lolli ML; Spyrakis F; Oliaro-Bosso S; Boschi D
    Eur J Med Chem; 2022 Jul; 237():114366. PubMed ID: 35447434
    [TBL] [Abstract][Full Text] [Related]  

  • 4. AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells.
    Verma K; Gupta N; Zang T; Wangtrakluldee P; Srivastava SK; Penning TM; Trippier PC
    Mol Cancer Ther; 2018 Sep; 17(9):1833-1845. PubMed ID: 29891491
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
    Adeniji AO; Twenter BM; Byrns MC; Jin Y; Chen M; Winkler JD; Penning TM
    J Med Chem; 2012 Mar; 55(5):2311-23. PubMed ID: 22263837
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics.
    Wangtrakuldee P; Adeniji AO; Zang T; Duan L; Khatri B; Twenter BM; Estrada MA; Higgins TF; Winkler JD; Penning TM
    J Steroid Biochem Mol Biol; 2019 Sep; 192():105283. PubMed ID: 30641225
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor.
    Adeniji A; Uddin MJ; Zang T; Tamae D; Wangtrakuldee P; Marnett LJ; Penning TM
    J Med Chem; 2016 Aug; 59(16):7431-44. PubMed ID: 27486833
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives Containing Benzoic Acid Group as Potential AKR1C3 Inhibitors.
    Sun M; Zhou Y; Zhuo X; Wang S; Jiang S; Peng Z; Kang K; Zheng X; Sun M
    Chem Biodivers; 2020 Dec; 17(12):e2000519. PubMed ID: 33111427
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer.
    Endo S; Oguri H; Segawa J; Kawai M; Hu D; Xia S; Okada T; Irie K; Fujii S; Gouda H; Iguchi K; Matsukawa T; Fujimoto N; Nakayama T; Toyooka N; Matsunaga T; Ikari A
    J Med Chem; 2020 Sep; 63(18):10396-10411. PubMed ID: 32847363
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
    Hendriks CM; Penning TM; Zang T; Wiemuth D; Gründer S; Sanhueza IA; Schoenebeck F; Bolm C
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4437-40. PubMed ID: 26372652
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A Mansonone Derivative Coupled with Monoclonal Antibody 4D5-Modified Chitosan Inhibit AKR1C3 to Treat Castration-Resistant Prostate Cancer.
    Zhou M; Wang X; Xia J; Cheng Y; Xiao L; Bei Y; Tang J; Huang Y; Xiang Q; Huang S
    Int J Nanomedicine; 2020; 15():3087-3098. PubMed ID: 32431503
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Reversal of Apalutamide and Darolutamide Aldo-Keto Reductase 1C3-Mediated Resistance by a Small Molecule Inhibitor.
    Morsy A; Trippier PC
    ACS Chem Biol; 2020 Mar; 15(3):646-650. PubMed ID: 32125151
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.
    Penning TM
    Expert Opin Ther Pat; 2017 Dec; 27(12):1329-1340. PubMed ID: 28895472
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia.
    Verma K; Zang T; Penning TM; Trippier PC
    J Med Chem; 2019 Apr; 62(7):3590-3616. PubMed ID: 30836001
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
    Flanagan JU; Yosaatmadja Y; Teague RM; Chai MZ; Turnbull AP; Squire CJ
    PLoS One; 2012; 7(8):e43965. PubMed ID: 22937138
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3.
    Lolli ML; Carnovale IM; Pippione AC; Wahlgren WY; Bonanni D; Marini E; Zonari D; Gallicchio M; Boscaro V; Goyal P; Friemann R; Rolando B; Bagnati R; Adinolfi S; Oliaro-Bosso S; Boschi D
    ACS Med Chem Lett; 2019 Apr; 10(4):437-443. PubMed ID: 30996776
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.
    Pippione AC; Kovachka S; Vigato C; Bertarini L; Mannella I; Sainas S; Rolando B; Denasio E; Piercy-Mycock H; Romalho L; Salladini E; Adinolfi S; Zonari D; Peraldo-Neia C; Chiorino G; Passoni A; Mirza OA; Frydenvang K; Pors K; Lolli ML; Spyrakis F; Oliaro-Bosso S; Boschi D
    Eur J Med Chem; 2024 Mar; 268():116193. PubMed ID: 38364714
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors.
    Zheng X; Jiang Z; Li X; Zhang C; Li Z; Wu Y; Wang X; Zhang C; Luo HB; Xu J; Wu D
    Bioorg Med Chem; 2018 Dec; 26(22):5934-5943. PubMed ID: 30429100
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells.
    Sali VK; Mani S; Meenaloshani G; Velmurugan Ilavarasi A; Vasanthi HR
    Steroids; 2020 Jul; 159():108638. PubMed ID: 32209376
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride.
    Byrns MC; Mindnich R; Duan L; Penning TM
    J Steroid Biochem Mol Biol; 2012 May; 130(1-2):7-15. PubMed ID: 22265960
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.