BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

110 related articles for article (PubMed ID: 29606576)

  • 1. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.
    Periasamy J; Kurdekar V; Jasti S; Nijaguna MB; Boggaram S; Hurakadli MA; Raina D; Kurup LM; Chintha C; Manjunath K; Goyal A; Sadasivam G; Bharatham K; Padigaru M; Potluri V; Venkitaraman AR
    Cell Chem Biol; 2018 Jun; 25(6):677-690.e12. PubMed ID: 29606576
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Peptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domain.
    White ER; Sun L; Ma Z; Beckta JM; Danzig BA; Hacker DE; Huie M; Williams DC; Edwards RA; Valerie K; Glover JN; Hartman MC
    ACS Chem Biol; 2015 May; 10(5):1198-208. PubMed ID: 25654734
    [TBL] [Abstract][Full Text] [Related]  

  • 3. BRCA1 and Its Vulnerable C-Terminal BRCT Domain: Structure, Function, Genetic Mutations and Links to Diagnosis and Treatment of Breast and Ovarian Cancer.
    Ismail T; Alzneika S; Riguene E; Al-Maraghi S; Alabdulrazzak A; Al-Khal N; Fetais S; Thanassoulas A; AlFarsi H; Nomikos M
    Pharmaceuticals (Basel); 2024 Mar; 17(3):. PubMed ID: 38543119
    [TBL] [Abstract][Full Text] [Related]  

  • 4. NMR study of the structure and dynamics of the BRCT domain from the kinetochore protein KKT4.
    Ludzia P; Hayashi H; Robinson T; Akiyoshi B; Redfield C
    Biomol NMR Assign; 2024 Jun; 18(1):15-25. PubMed ID: 38453826
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
    Gupta R; Somyajit K; Narita T; Maskey E; Stanlie A; Kremer M; Typas D; Lammers M; Mailand N; Nussenzweig A; Lukas J; Choudhary C
    Cell; 2018 May; 173(4):972-988.e23. PubMed ID: 29656893
    [TBL] [Abstract][Full Text] [Related]  

  • 6. DNA repair and cell cycle checkpoint defects in a mouse model of 'BRCAness' are partially rescued by 53BP1 deletion.
    Misenko SM; Patel DS; Her J; Bunting SF
    Cell Cycle; 2018; 17(7):881-891. PubMed ID: 29620483
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
    Trenner A; Godau J; Sartori AA
    Mol Cancer Ther; 2018 Jul; 17(7):1392-1404. PubMed ID: 29654063
    [TBL] [Abstract][Full Text] [Related]  

  • 8. RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
    Cruz C; Castroviejo-Bermejo M; Gutiérrez-Enríquez S; Llop-Guevara A; Ibrahim YH; Gris-Oliver A; Bonache S; Morancho B; Bruna A; Rueda OM; Lai Z; Polanska UM; Jones GN; Kristel P; de Bustos L; Guzman M; Rodríguez O; Grueso J; Montalban G; Caratú G; Mancuso F; Fasani R; Jiménez J; Howat WJ; Dougherty B; Vivancos A; Nuciforo P; Serres-Créixams X; Rubio IT; Oaknin A; Cadogan E; Barrett JC; Caldas C; Baselga J; Saura C; Cortés J; Arribas J; Jonkers J; Díez O; O'Connor MJ; Balmaña J; Serra V
    Ann Oncol; 2018 May; 29(5):1203-1210. PubMed ID: 29635390
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
    Knijnenburg TA; Wang L; Zimmermann MT; Chambwe N; Gao GF; Cherniack AD; Fan H; Shen H; Way GP; Greene CS; Liu Y; Akbani R; Feng B; Donehower LA; Miller C; Shen Y; Karimi M; Chen H; Kim P; Jia P; Shinbrot E; Zhang S; Liu J; Hu H; Bailey MH; Yau C; Wolf D; Zhao Z; Weinstein JN; Li L; Ding L; Mills GB; Laird PW; Wheeler DA; Shmulevich I; ; Monnat RJ; Xiao Y; Wang C
    Cell Rep; 2018 Apr; 23(1):239-254.e6. PubMed ID: 29617664
    [TBL] [Abstract][Full Text] [Related]  

  • 10. BRD4 facilitates replication stress-induced DNA damage response.
    Zhang J; Dulak AM; Hattersley MM; Willis BS; Nikkilä J; Wang A; Lau A; Reimer C; Zinda M; Fawell SE; Mills GB; Chen H
    Oncogene; 2018 Jul; 37(28):3763-3777. PubMed ID: 29636547
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements.
    Mendez-Dorantes C; Bhargava R; Stark JM
    Genes Dev; 2018 Apr; 32(7-8):524-536. PubMed ID: 29636371
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Homologous Recombination and Replication Fork Protection: BRCA2 and More!
    Feng W; Jasin M
    Cold Spring Harb Symp Quant Biol; 2017; 82():329-338. PubMed ID: 29686033
    [TBL] [Abstract][Full Text] [Related]  

  • 13. APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency.
    Tsai CY; Sun S; Zhang H; Local A; Su Y; Gross LA; Rice WG; Howell SB
    Mol Cancer Ther; 2018 Jun; 17(6):1167-1176. PubMed ID: 29626126
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks.
    Leland BA; Chen AC; Zhao AY; Wharton RC; King MC
    Elife; 2018 Apr; 7():. PubMed ID: 29697047
    [TBL] [Abstract][Full Text] [Related]  

  • 15. RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.
    Zhao H; Zhu M; Limbo O; Russell P
    EMBO Rep; 2018 May; 19(5):. PubMed ID: 29622660
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
    Syed A; Tainer JA
    Annu Rev Biochem; 2018 Jun; 87():263-294. PubMed ID: 29709199
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.
    Kotsantis P; Petermann E; Boulton SJ
    Cancer Discov; 2018 May; 8(5):537-555. PubMed ID: 29653955
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-Guided Synthesis and Evaluation of Small-Molecule Inhibitors Targeting Protein-Protein Interactions of BRCA1 tBRCT Domain.
    Kurdekar V; Giridharan S; Subbarao J; Nijaguna MB; Periasamy J; Boggaram S; Shivange AV; Sadasivam G; Padigaru M; Potluri V; Venkitaraman AR; Bharatham K
    ChemMedChem; 2019 Sep; 14(18):1620-1632. PubMed ID: 31334915
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library.
    Emery A; Hardwick BS; Crooks AT; Milech N; Watt PM; Mithra C; Kumar V; Giridharan S; Sadasivam G; Mathivanan S; Sudhakar S; Bairy S; Bharatham K; Hurakadli MA; Prasad TK; Kamariah N; Muellner M; Coelho M; Torrance CJ; McKenzie GJ; Venkitaraman AR
    Cell Chem Biol; 2021 Nov; 28(11):1602-1615.e9. PubMed ID: 34111400
    [TBL] [Abstract][Full Text] [Related]  

  • 20. BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance.
    Renaudin X; Lee M; Shehata M; Surmann EM; Venkitaraman AR
    Cell Rep; 2021 Aug; 36(5):109478. PubMed ID: 34348152
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.