BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 29620892)

  • 21. Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials.
    Matralis AN; Afantitis A; Aidinis V
    Med Res Rev; 2019 May; 39(3):976-1013. PubMed ID: 30462853
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
    Stein AJ; Bain G; Prodanovich P; Santini AM; Darlington J; Stelzer NM; Sidhu RS; Schaub J; Goulet L; Lonergan D; Calderon I; Evans JF; Hutchinson JH
    Mol Pharmacol; 2015 Dec; 88(6):982-92. PubMed ID: 26371182
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.
    Pantsar T; Singha P; Nevalainen TJ; Koshevoy I; Leppänen J; Poso A; Niskanen JMA; Pasonen-Seppänen S; Savinainen JR; Laitinen T; Laitinen JT
    Eur J Pharm Sci; 2017 Sep; 107():97-111. PubMed ID: 28687529
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects.
    Lei H; Li C; Yang Y; Jia F; Guo M; Zhu M; Jiang N; Zhai X
    Eur J Med Chem; 2020 Sep; 201():112456. PubMed ID: 32535330
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
    Fells JI; Lee SC; Fujiwara Y; Norman DD; Lim KG; Tsukahara R; Liu J; Patil R; Miller DD; Kirby RJ; Nelson S; Seibel W; Papoian R; Parrill AL; Baker DL; Bittman R; Tigyi G
    Mol Pharmacol; 2013 Sep; 84(3):415-24. PubMed ID: 23793291
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Ligand-based autotaxin pharmacophore models reflect structure-based docking results.
    Mize CD; Abbott AM; Gacasan SB; Parrill AL; Baker DL
    J Mol Graph Model; 2011 Nov; 31():76-86. PubMed ID: 21967734
    [TBL] [Abstract][Full Text] [Related]  

  • 27. An updated patent review of autotaxin inhibitors (2017-present).
    Tan Z; Lei H; Guo M; Chen Y; Zhai X
    Expert Opin Ther Pat; 2021 May; 31(5):421-434. PubMed ID: 33342311
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Structure-based design of novel boronic acid-based inhibitors of autotaxin.
    Albers HM; Hendrickx LJ; van Tol RJ; Hausmann J; Perrakis A; Ovaa H
    J Med Chem; 2011 Jul; 54(13):4619-26. PubMed ID: 21615078
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Recent research advances in ATX inhibitors: An overview of primary literature.
    Zhang C; Liu Y; Zhou Q; Fan H; Liu X; Hu J
    Bioorg Med Chem; 2023 Jul; 90():117374. PubMed ID: 37354726
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discovery of potent inhibitors of the lysophospholipase autotaxin.
    Shah P; Cheasty A; Foxton C; Raynham T; Farooq M; Gutierrez IF; Lejeune A; Pritchard M; Turnbull A; Pang L; Owen P; Boyd S; Stowell A; Jordan A; Hamilton NM; Hitchin JR; Stockley M; MacDonald E; Quesada MJ; Trivier E; Skeete J; Ovaa H; Moolenaar WH; Ryder H
    Bioorg Med Chem Lett; 2016 Nov; 26(22):5403-5410. PubMed ID: 27780639
    [TBL] [Abstract][Full Text] [Related]  

  • 31. alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors.
    Cui P; McCalmont WF; Tomsig JL; Lynch KR; Macdonald TL
    Bioorg Med Chem; 2008 Mar; 16(5):2212-25. PubMed ID: 18082408
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Autotaxin and chronic inflammatory diseases.
    Magkrioti C; Galaris A; Kanellopoulou P; Stylianaki EA; Kaffe E; Aidinis V
    J Autoimmun; 2019 Nov; 104():102327. PubMed ID: 31471142
    [TBL] [Abstract][Full Text] [Related]  

  • 33. "Hit" to lead optimization and chemoinformatic studies for a new series of Autotaxin inhibitors.
    Stylianaki EA; Magkrioti C; Ladopoulou EM; Papavasileiou KD; Lagarias P; Melagraki G; Samiotaki M; Panayotou G; Dedos SG; Afantitis A; Aidinis V; Matralis AN
    Eur J Med Chem; 2023 Mar; 249():115130. PubMed ID: 36702053
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.
    Kawaguchi M; Okabe T; Okudaira S; Nishimasu H; Ishitani R; Kojima H; Nureki O; Aoki J; Nagano T
    ACS Chem Biol; 2013 Aug; 8(8):1713-21. PubMed ID: 23688339
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors.
    Banerjee S; Norman DD; Deng S; Fakayode SO; Lee SC; Parrill AL; Li W; Miller DD; Tigyi GJ
    Bioorg Chem; 2020 Oct; 103():104188. PubMed ID: 32890995
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.
    Barbayianni E; Kaffe E; Aidinis V; Kokotos G
    Prog Lipid Res; 2015 Apr; 58():76-96. PubMed ID: 25704398
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Design, Synthesis, and Preliminary Bioactivity Evaluation of 2,7-Substituted Carbazole Derivatives as Potent Autotaxin Inhibitors and Antitumor Agents†.
    Wang W; Zhao F; Zhao Y; Pan W; Cao P; Wu L; Wang Z; Zhao X; Zhao Y; Wang H
    Anticancer Agents Med Chem; 2019; 19(2):256-264. PubMed ID: 30173652
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors.
    Magkrioti C; Kaffe E; Stylianaki EA; Sidahmet C; Melagraki G; Afantitis A; Matralis AN; Aidinis V
    Int J Mol Sci; 2020 Sep; 21(19):. PubMed ID: 32977539
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Development of autotaxin inhibitors: A series of zinc binding triazoles.
    Thomson CG; Le Grand D; Dowling M; Brocklehurst CE; Chinn C; Elphick L; Faller M; Freeman M; Furminger V; Gasser C; Hamadi A; Hardaker E; Head V; Hill JC; Janus DI; Pearce D; Poulaud AS; Stanley E; Sviridenko L
    Bioorg Med Chem Lett; 2018 Jul; 28(13):2279-2284. PubMed ID: 29798825
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Benzoxaboroles-Novel Autotaxin Inhibitors.
    Kraljić K; Jelić D; Žiher D; Cvrtila A; Dragojević S; Sinković V; Mesić M
    Molecules; 2019 Sep; 24(19):. PubMed ID: 31547058
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.