BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 29626127)

  • 1. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells.
    Local A; Zhang H; Benbatoul KD; Folger P; Sheng X; Tsai CY; Howell SB; Rice WG
    Mol Cancer Ther; 2018 Jun; 17(6):1177-1186. PubMed ID: 29626127
    [TBL] [Abstract][Full Text] [Related]  

  • 2. APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency.
    Tsai CY; Sun S; Zhang H; Local A; Su Y; Gross LA; Rice WG; Howell SB
    Mol Cancer Ther; 2018 Jun; 17(6):1167-1176. PubMed ID: 29626126
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells.
    Montoya JJ; Turnidge MA; Wai DH; Patel AR; Lee DW; Gokhale V; Hurley LH; Arceci RJ; Wetmore C; Azorsa DO
    BMC Cancer; 2019 Dec; 19(1):1251. PubMed ID: 31881855
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Drug-like biimidazole derivatives dually target c-MYC/BCL-2 G-quadruplexes and inhibit acute myeloid leukemia.
    Hu MH; Yu BY; Wang X; Jin G
    Bioorg Chem; 2020 Nov; 104():104264. PubMed ID: 32920366
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes.
    Medeiros-Silva J; Guédin A; Salgado GF; Mergny JL; Queiroz JA; Cabrita EJ; Cruz C
    Biochim Biophys Acta Gen Subj; 2017 May; 1861(5 Pt B):1281-1292. PubMed ID: 27865994
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex.
    Wu TY; Huang Q; Huang ZS; Hu MH; Tan JH
    Bioorg Chem; 2020 Jun; 99():103866. PubMed ID: 32330737
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia.
    Huang MJ; Cheng YC; Liu CR; Lin S; Liu HE
    Exp Hematol; 2006 Nov; 34(11):1480-9. PubMed ID: 17046567
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.
    Hu MH; Wang YQ; Yu ZY; Hu LN; Ou TM; Chen SB; Huang ZS; Tan JH
    J Med Chem; 2018 Mar; 61(6):2447-2459. PubMed ID: 29474069
    [TBL] [Abstract][Full Text] [Related]  

  • 9. An in silico investigation of the binding modes and pathway of APTO-253 on c-KIT G-quadruplex DNA.
    Pal S; Paul S
    Phys Chem Chem Phys; 2021 Feb; 23(5):3361-3376. PubMed ID: 33502401
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tanshinone IIA derivatives induced S-phase arrest through stabilizing c-myc G-quadruplex DNA to regulate ROS-mediated PI3K/Akt/mTOR pathway.
    Wang T; Zou J; Wu Q; Wang R; Yuan CL; Shu J; Zhai BB; Huang XT; Liu NZ; Hua FY; Wang XC; Mei WJ
    Eur J Pharmacol; 2021 Dec; 912():174586. PubMed ID: 34710368
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo.
    Li Z; Liu C; Huang C; Meng X; Zhang L; He J; Li J
    Oncotarget; 2016 Jun; 7(23):34266-76. PubMed ID: 27144522
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Axolotl
    Suleiman S; Di Fiore R; Cassar A; Formosa MM; Schembri-Wismayer P; Calleja-Agius J
    Tumour Biol; 2020 Sep; 42(9):1010428320954735. PubMed ID: 32873193
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells.
    Secchiero P; Zerbinati C; di Iasio MG; Melloni E; Tiribelli M; Grill V; Zauli G
    Curr Drug Metab; 2007 May; 8(4):395-403. PubMed ID: 17504227
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells.
    Nagesh N; Raju G; Srinivas R; Ramesh P; Reddy MD; Reddy ChR
    Biochim Biophys Acta; 2015 Jan; 1850(1):129-40. PubMed ID: 25452213
    [TBL] [Abstract][Full Text] [Related]  

  • 15. AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
    Eriksson A; Kalushkova A; Jarvius M; Hilhorst R; Rickardson L; Kultima HG; de Wijn R; Hovestad L; Fryknäs M; Öberg F; Larsson R; Parrow V; Höglund M
    Biochem Pharmacol; 2014 Jan; 87(2):284-91. PubMed ID: 24200998
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex.
    Dutta D; Debnath M; Müller D; Paul R; Das T; Bessi I; Schwalbe H; Dash J
    Nucleic Acids Res; 2018 Jun; 46(11):5355-5365. PubMed ID: 29762718
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression.
    Felsenstein KM; Saunders LB; Simmons JK; Leon E; Calabrese DR; Zhang S; Michalowski A; Gareiss P; Mock BA; Schneekloth JS
    ACS Chem Biol; 2016 Jan; 11(1):139-48. PubMed ID: 26462961
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ruthenium(II) complexes as apoptosis inducers by stabilizing c-myc G-quadruplex DNA.
    Zhang Z; Wu Q; Wu XH; Sun FY; Chen LM; Chen JC; Yang SL; Mei WJ
    Eur J Med Chem; 2014 Jun; 80():316-24. PubMed ID: 24793882
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phenanthroline polyazamacrocycles as G-quadruplex DNA binders.
    Carvalho J; Quintela T; Gueddouda NM; Bourdoncle A; Mergny JL; Salgado GF; Queiroz JA; Cruz C
    Org Biomol Chem; 2018 Apr; 16(15):2776-2786. PubMed ID: 29611599
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stabilization of c-myc G-Quadruplex DNA, inhibition of telomerase activity, disruption of mitochondrial functions and tumor cell apoptosis by platinum(II) complex with 9-amino-oxoisoaporphine.
    Qin JL; Qin QP; Wei ZZ; Yu YC; Meng T; Wu CX; Liang YL; Liang H; Chen ZF
    Eur J Med Chem; 2016 Nov; 124():417-427. PubMed ID: 27597417
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.