180 related articles for article (PubMed ID: 29641204)
1. Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
Li J; Li S; Guo J; Li Q; Long J; Ma C; Ding Y; Yan C; Li L; Wu Z; Zhu H; Li KK; Wen L; Zhang Q; Xue Q; Zhao C; Liu N; Ivanov I; Luo M; Xi R; Long H; Wang PG; Chen Y
J Med Chem; 2018 May; 61(9):4155-4164. PubMed ID: 29641204
[TBL] [Abstract][Full Text] [Related]
2. The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress.
Masaki S; Hashimoto K; Kihara D; Tsuzuki C; Kataoka N; Suzuki K
Biochem Biophys Res Commun; 2020 Jun; 526(4):973-977. PubMed ID: 32295714
[TBL] [Abstract][Full Text] [Related]
3. PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells.
Yu Z; Huang L; Qiao P; Jiang A; Wang L; Yang T; Tang S; Zhang W; Ren C
Biochem Biophys Res Commun; 2016 May; 473(4):953-958. PubMed ID: 27045080
[TBL] [Abstract][Full Text] [Related]
4. Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.
Patle R; Shinde S; Patel S; Maheshwari R; Jariyal H; Srivastava A; Chauhan N; Globisch C; Jain A; Tekade RK; Shard A
Bioorg Med Chem Lett; 2021 Jun; 42():128062. PubMed ID: 33901643
[TBL] [Abstract][Full Text] [Related]
5. Structural insight into mechanisms for dynamic regulation of PKM2.
Wang P; Sun C; Zhu T; Xu Y
Protein Cell; 2015 Apr; 6(4):275-287. PubMed ID: 25645022
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors.
Liu B; Yuan X; Xu B; Zhang H; Li R; Wang X; Ge Z; Li R
Eur J Med Chem; 2019 May; 170():1-15. PubMed ID: 30878825
[TBL] [Abstract][Full Text] [Related]
7. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.
Lv L; Xu YP; Zhao D; Li FL; Wang W; Sasaki N; Jiang Y; Zhou X; Li TT; Guan KL; Lei QY; Xiong Y
Mol Cell; 2013 Nov; 52(3):340-52. PubMed ID: 24120661
[TBL] [Abstract][Full Text] [Related]
8. Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?
Chhipa AS; Patel S
Life Sci; 2021 Sep; 280():119694. PubMed ID: 34102192
[TBL] [Abstract][Full Text] [Related]
9. Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation.
Xie X; Wang M; Mei J; Hu F; Ding F; Lv L
Biochem Biophys Res Commun; 2015 Nov; 467(2):427-33. PubMed ID: 26410533
[TBL] [Abstract][Full Text] [Related]
10. Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.
Giannoni E; Taddei ML; Morandi A; Comito G; Calvani M; Bianchini F; Richichi B; Raugei G; Wong N; Tang D; Chiarugi P
Oncotarget; 2015 Sep; 6(27):24061-74. PubMed ID: 26183399
[TBL] [Abstract][Full Text] [Related]
11. Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.
Liu VM; Howell AJ; Hosios AM; Li Z; Israelsen WJ; Vander Heiden MG
FEBS Lett; 2020 Feb; 594(4):646-664. PubMed ID: 31642061
[TBL] [Abstract][Full Text] [Related]
12. Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species.
Yokoyama M; Tanuma N; Shibuya R; Shiroki T; Abue M; Yamamoto K; Miura K; Yamaguchi K; Sato I; Tamai K; Satoh K
Int J Oncol; 2018 Mar; 52(3):881-891. PubMed ID: 29393401
[TBL] [Abstract][Full Text] [Related]
13. HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
Xu Q; Tu J; Dou C; Zhang J; Yang L; Liu X; Lei K; Liu Z; Wang Y; Li L; Bao H; Wang J; Tu K
Mol Cancer; 2017 Dec; 16(1):178. PubMed ID: 29262861
[TBL] [Abstract][Full Text] [Related]
14. PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
Liu F; Ma F; Wang Y; Hao L; Zeng H; Jia C; Wang Y; Liu P; Ong IM; Li B; Chen G; Jiang J; Gong S; Li L; Xu W
Nat Cell Biol; 2017 Nov; 19(11):1358-1370. PubMed ID: 29058718
[TBL] [Abstract][Full Text] [Related]
15. Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2.
Srivastava D; Razzaghi M; Henzl MT; Dey M
Biochemistry; 2017 Dec; 56(50):6517-6520. PubMed ID: 29182273
[TBL] [Abstract][Full Text] [Related]
16. Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2.
Nandi S; Dey M
J Biol Chem; 2020 Apr; 295(16):5390-5403. PubMed ID: 32144209
[TBL] [Abstract][Full Text] [Related]
17. Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
Parnell KM; Foulks JM; Nix RN; Clifford A; Bullough J; Luo B; Senina A; Vollmer D; Liu J; McCarthy V; Xu Y; Saunders M; Liu XH; Pearce S; Wright K; O'Reilly M; McCullar MV; Ho KK; Kanner SB
Mol Cancer Ther; 2013 Aug; 12(8):1453-60. PubMed ID: 23720766
[TBL] [Abstract][Full Text] [Related]
18. 1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Yacovan A; Ozeri R; Kehat T; Mirilashvili S; Sherman D; Aizikovich A; Shitrit A; Ben-Zeev E; Schutz N; Bohana-Kashtan O; Konson A; Behar V; Becker OM
Bioorg Med Chem Lett; 2012 Oct; 22(20):6460-8. PubMed ID: 22963766
[TBL] [Abstract][Full Text] [Related]
19. Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
Fukuda S; Miyata H; Miyazaki Y; Makino T; Takahashi T; Kurokawa Y; Yamasaki M; Nakajima K; Takiguchi S; Mori M; Doki Y
Ann Surg Oncol; 2015 Dec; 22 Suppl 3():S1461-8. PubMed ID: 25808097
[TBL] [Abstract][Full Text] [Related]
20. Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth.
Xiangyun Y; Xiaomin N; Linping G; Yunhua X; Ziming L; Yongfeng Y; Zhiwei C; Shun L
Oncotarget; 2017 Jan; 8(4):6984-6993. PubMed ID: 28036303
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
