These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 29655610)

  • 1. Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.
    Xiang W; Choudhary S; Hamel E; Mooberry SL; Gangjee A
    Bioorg Med Chem; 2018 May; 26(9):2437-2451. PubMed ID: 29655610
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, Synthesis and Molecular Docking Studies of Novel Indole-Pyrimidine Hybrids as Tubulin Polymerization Inhibitors.
    Hu MJ; Zhang B; Yang HK; Liu Y; Chen YR; Ma TZ; Lu L; You WW; Zhao PL
    Chem Biol Drug Des; 2015 Dec; 86(6):1491-500. PubMed ID: 26177395
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and thiomorpholine moieties.
    Diao PC; Li Q; Hu MJ; Ma YF; You WW; Hong KH; Zhao PL
    Eur J Med Chem; 2017 Jul; 134():110-118. PubMed ID: 28410492
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-
    Islam F; Doshi A; Robles AJ; Quadery TM; Zhang X; Zhou X; Hamel E; Mooberry SL; Gangjee A
    Molecules; 2022 Jan; 27(1):. PubMed ID: 35011550
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.
    Li G; Wang Y; Li L; Ren Y; Deng X; Liu J; Wang W; Luo M; Liu S; Chen J
    Eur J Med Chem; 2020 Sep; 202():112519. PubMed ID: 32650183
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.
    Devambatla RKV; Li W; Zaware N; Choudhary S; Hamel E; Mooberry SL; Gangjee A
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3423-3430. PubMed ID: 28610978
    [TBL] [Abstract][Full Text] [Related]  

  • 7. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition.
    Singh A; Chang TY; Kaur N; Hsu KC; Yen Y; Lin TE; Lai MJ; Lee SB; Liou JP
    Eur J Med Chem; 2021 Apr; 215():113169. PubMed ID: 33588178
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
    Gangjee A; Zhao Y; Lin L; Raghavan S; Roberts EG; Risinger AL; Hamel E; Mooberry SL
    J Med Chem; 2010 Nov; 53(22):8116-28. PubMed ID: 20973488
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.
    Pavana RK; Shah K; Gentile T; Dybdal-Hargreaves NF; Risinger AL; Mooberry SL; Hamel E; Gangjee A
    Bioorg Med Chem; 2018 Nov; 26(20):5470-5478. PubMed ID: 30297118
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities.
    Yang F; Yu LZ; Diao PC; Jian XE; Zhou MF; Jiang CS; You WW; Ma WF; Zhao PL
    Bioorg Chem; 2019 Nov; 92():103260. PubMed ID: 31525523
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors.
    Xu S; An B; Li Y; Luo X; Li X; Jia X
    Bioorg Med Chem Lett; 2018 Jun; 28(10):1769-1775. PubMed ID: 29673981
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Anti-proliferative potential of triphenyl substituted pyrimidines against MDA-MB-231, HCT-116 and HT-29 cancer cell lines.
    Ranjan Dwivedi A; Kumar V; Kaur H; Kumar N; Prakash Yadav R; Poduri R; Baranwal S; Kumar V
    Bioorg Med Chem Lett; 2020 Oct; 30(20):127468. PubMed ID: 32768647
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.
    Xiang W; Quadery TM; Hamel E; Luckett-Chastain LR; Ihnat MA; Mooberry SL; Gangjee A
    Bioorg Med Chem; 2021 Jan; 29():115887. PubMed ID: 33310545
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel water-soluble substituted pyrrolo[3,2-d]pyrimidines: design, synthesis, and biological evaluation as antitubulin antitumor agents.
    Gangjee A; Pavana RK; Li W; Hamel E; Westbrook C; Mooberry SL
    Pharm Res; 2012 Nov; 29(11):3033-9. PubMed ID: 22814902
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues.
    Pecnard S; Hamze A; Bignon J; Prost B; Deroussent A; Gallego-Yerga L; Peláez R; Paik JY; Diederich M; Alami M; Provot O
    Eur J Med Chem; 2021 Nov; 223():113656. PubMed ID: 34171660
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
    Wu C; Zhang L; Zhou Z; Tan L; Wang Z; Guo C; Wang Y
    Eur J Med Chem; 2024 Oct; 276():116649. PubMed ID: 38972078
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents.
    Yang J; Yang S; Zhou S; Lu D; Ji L; Li Z; Yu S; Meng X
    Eur J Med Chem; 2016 Oct; 122():488-496. PubMed ID: 27423028
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents.
    Carta D; Bortolozzi R; Sturlese M; Salmaso V; Hamel E; Basso G; Calderan L; Quintieri L; Moro S; Viola G; Ferlin MG
    Eur J Med Chem; 2017 Feb; 127():643-660. PubMed ID: 27823884
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis and biological studies of novel tubulin inhibitors.
    Sun Y; Pandit B; Chettiar SN; Etter JP; Lewis A; Johnsamuel J; Li PK
    Bioorg Med Chem Lett; 2013 Aug; 23(15):4465-8. PubMed ID: 23790539
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents.
    Hu Y; Lu X; Chen K; Yan R; Li QS; Zhu HL
    Bioorg Med Chem; 2012 Jan; 20(2):903-9. PubMed ID: 22192936
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.