These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 29665350)

  • 1. PXR: Structure-specific activation by hepatotoxic pyrrolizidine alkaloids.
    Luckert C; Braeuning A; Lampen A; Hessel-Pras S
    Chem Biol Interact; 2018 May; 288():38-48. PubMed ID: 29665350
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.
    Ruan J; Yang M; Fu P; Ye Y; Lin G
    Chem Res Toxicol; 2014 Jun; 27(6):1030-9. PubMed ID: 24836403
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-dependent induction of apoptosis by hepatotoxic pyrrolizidine alkaloids in the human hepatoma cell line HepaRG: Single versus repeated exposure.
    Waizenegger J; Braeuning A; Templin M; Lampen A; Hessel-Pras S
    Food Chem Toxicol; 2018 Apr; 114():215-226. PubMed ID: 29458164
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Editor's Highlight: Identification of Any Structure-Specific Hepatotoxic Potential of Different Pyrrolizidine Alkaloids Using Random Forests and Artificial Neural Networks.
    Schöning V; Hammann F; Peinl M; Drewe J
    Toxicol Sci; 2017 Dec; 160(2):361-370. PubMed ID: 28973379
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
    Luckert C; Ehlers A; Buhrke T; Seidel A; Lampen A; Hessel S
    Toxicol Lett; 2013 Oct; 222(2):180-8. PubMed ID: 23845848
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells.
    Rutz L; Gao L; Küpper JH; Schrenk D
    Arch Toxicol; 2020 Dec; 94(12):4159-4172. PubMed ID: 32910235
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model.
    Li YH; Kan WL; Li N; Lin G
    J Ethnopharmacol; 2013 Nov; 150(2):560-7. PubMed ID: 24045176
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pyrrolizidine Alkaloids Induce Cell Death in Human HepaRG Cells in a Structure-Dependent Manner.
    Glück J; Waizenegger J; Braeuning A; Hessel-Pras S
    Int J Mol Sci; 2020 Dec; 22(1):. PubMed ID: 33379168
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolic Pattern of Hepatotoxic Pyrrolizidine Alkaloids in Liver Cells.
    Geburek I; Rutz L; Gao L; Küpper JH; These A; Schrenk D
    Chem Res Toxicol; 2021 Apr; 34(4):1101-1113. PubMed ID: 33719395
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates.
    Tamta H; Pawar RS; Wamer WG; Grundel E; Krynitsky AJ; Rader JI
    Xenobiotica; 2012 Oct; 42(10):1038-48. PubMed ID: 22519982
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The toxicokinetic and metabolism of structurally diverse pyrrolizidine alkaloids in rats.
    To YC; Pan Y; Yan X; He Y; Lin G
    J Ethnopharmacol; 2024 Mar; 321():117390. PubMed ID: 37956911
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis.
    Luckert C; Hessel S; Lenze D; Lampen A
    Toxicol In Vitro; 2015 Oct; 29(7):1669-82. PubMed ID: 26100227
    [TBL] [Abstract][Full Text] [Related]  

  • 13. OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects.
    Haas M; Ackermann G; Küpper JH; Glatt H; Schrenk D; Fahrer J
    Arch Toxicol; 2023 Dec; 97(12):3259-3271. PubMed ID: 37676300
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids.
    Fashe MM; Juvonen RO; Petsalo A; Vepsäläinen J; Pasanen M; Rahnasto-Rilla M
    Chem Res Toxicol; 2015 Apr; 28(4):702-10. PubMed ID: 25651456
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.
    Watanabe K; Sakurai K; Tsuchiya Y; Yamazoe Y; Yoshinari K
    Biochem Pharmacol; 2013 Aug; 86(3):428-36. PubMed ID: 23732298
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids.
    Yang M; Ma J; Ruan J; Ye Y; Fu PP; Lin G
    Arch Toxicol; 2019 Aug; 93(8):2197-2209. PubMed ID: 31222523
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of an in vitro screening method of acute cytotoxicity of the pyrrolizidine alkaloid lasiocarpine in human and rodent hepatic cell lines by increasing susceptibility.
    Forsch K; Schöning V; Disch L; Siewert B; Unger M; Drewe J
    J Ethnopharmacol; 2018 May; 217():134-139. PubMed ID: 29454024
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The chemical structure impairs the intensity of genotoxic effects promoted by 1,2-unsaturated pyrrolizidine alkaloids in vitro.
    Buchmueller J; Enge AM; Peters A; Ebmeyer J; Küpper JH; Schäfer B; Braeuning A; Hessel-Pras S
    Food Chem Toxicol; 2022 Jun; 164():113049. PubMed ID: 35500694
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells.
    Abdelfatah S; Naß J; Knorz C; Klauck SM; Küpper JH; Efferth T
    Cell Biol Toxicol; 2022 Apr; 38(2):325-345. PubMed ID: 33884520
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Establishment of a novel CYP3A4-transduced human hepatic sinusoidal endothelial cell model and its application in screening hepatotoxicity of pyrrolizidine alkaloids.
    Lu Y; Wong KY; Tan C; Ma J; Feng B; Lin G
    J Environ Sci Health C Toxicol Carcinog; 2020; 38(2):169-185. PubMed ID: 32469285
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.