BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

263 related articles for article (PubMed ID: 29668927)

  • 1. Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
    Choi JC; Wu W; Phillips E; Plevin R; Sera F; Homma S; Worman HJ
    Hum Mol Genet; 2018 Jul; 27(13):2290-2305. PubMed ID: 29668927
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation.
    Choi JC; Wu W; Muchir A; Iwata S; Homma S; Worman HJ
    J Biol Chem; 2012 Nov; 287(48):40513-24. PubMed ID: 23048029
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation.
    Wu W; Iwata S; Homma S; Worman HJ; Muchir A
    Hum Mol Genet; 2014 Jan; 23(1):1-11. PubMed ID: 23933734
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.
    Muchir A; Shan J; Bonne G; Lehnart SE; Worman HJ
    Hum Mol Genet; 2009 Jan; 18(2):241-7. PubMed ID: 18927124
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.
    Wu W; Shan J; Bonne G; Worman HJ; Muchir A
    Biochim Biophys Acta; 2010; 1802(7-8):632-8. PubMed ID: 20388542
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.
    Muchir A; Reilly SA; Wu W; Iwata S; Homma S; Bonne G; Worman HJ
    Cardiovasc Res; 2012 Feb; 93(2):311-9. PubMed ID: 22068161
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation.
    Muchir A; Wu W; Sera F; Homma S; Worman HJ
    Biochem Biophys Res Commun; 2014 Oct; 452(4):958-61. PubMed ID: 25218145
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
    Wu W; Muchir A; Shan J; Bonne G; Worman HJ
    Circulation; 2011 Jan; 123(1):53-61. PubMed ID: 21173351
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Amelioration of desmin network defects by αB-crystallin overexpression confers cardioprotection in a mouse model of dilated cardiomyopathy caused by LMNA gene mutation.
    Galata Z; Kloukina I; Kostavasili I; Varela A; Davos CH; Makridakis M; Bonne G; Capetanaki Y
    J Mol Cell Cardiol; 2018 Dec; 125():73-86. PubMed ID: 30342008
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation.
    Muchir A; Wu W; Choi JC; Iwata S; Morrow J; Homma S; Worman HJ
    Hum Mol Genet; 2012 Oct; 21(19):4325-33. PubMed ID: 22773734
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis.
    Widyastuti HP; Norden-Krichmar TM; Grosberg A; Zaragoza MV
    BMC Med Genet; 2020 Jul; 21(1):152. PubMed ID: 32698886
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations.
    Arimura T; Onoue K; Takahashi-Tanaka Y; Ishikawa T; Kuwahara M; Setou M; Shigenobu S; Yamaguchi K; Bertrand AT; Machida N; Takayama K; Fukusato M; Tanaka R; Somekawa S; Nakano T; Yamane Y; Kuba K; Imai Y; Saito Y; Bonne G; Kimura A
    Cardiovasc Res; 2013 Aug; 99(3):382-94. PubMed ID: 23631840
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation.
    Dridi H; Wu W; Reiken SR; Ofer RM; Liu Y; Yuan Q; Sittenfeld L; Kushner J; Muchir A; Worman HJ; Marks AR
    Hum Mol Genet; 2021 Feb; 29(24):3919-3934. PubMed ID: 33388782
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy.
    Muchir A; Pavlidis P; Decostre V; Herron AJ; Arimura T; Bonne G; Worman HJ
    J Clin Invest; 2007 May; 117(5):1282-93. PubMed ID: 17446932
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation.
    Muchir A; Kim YJ; Reilly SA; Wu W; Choi JC; Worman HJ
    Skelet Muscle; 2013 Jul; 3(1):17. PubMed ID: 23815988
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cell signaling abnormalities in cardiomyopathy caused by lamin A/C gene mutations.
    Worman HJ
    Biochem Soc Trans; 2018 Feb; 46(1):37-42. PubMed ID: 29196611
    [TBL] [Abstract][Full Text] [Related]  

  • 17. ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.
    Antoku S; Wu W; Joseph LC; Morrow JP; Worman HJ; Gundersen GG
    Dev Cell; 2019 Dec; 51(5):602-616.e12. PubMed ID: 31794718
    [TBL] [Abstract][Full Text] [Related]  

  • 18. ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene.
    Chatzifrangkeskou M; Le Dour C; Wu W; Morrow JP; Joseph LC; Beuvin M; Sera F; Homma S; Vignier N; Mougenot N; Bonne G; Lipson KE; Worman HJ; Muchir A
    Hum Mol Genet; 2016 Jun; 25(11):2220-2233. PubMed ID: 27131347
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene.
    Le Dour C; Macquart C; Sera F; Homma S; Bonne G; Morrow JP; Worman HJ; Muchir A
    Hum Mol Genet; 2017 Jan; 26(2):333-343. PubMed ID: 28069793
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene Mutations.
    Muchir A; Worman HJ
    Methods Enzymol; 2016; 568():557-80. PubMed ID: 26795484
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.