BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

263 related articles for article (PubMed ID: 29669256)

  • 1. Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake.
    Kärkkäinen J; Gynther M; Kokkola T; Petsalo A; Auriola S; Lahtela-Kakkonen M; Laine K; Rautio J; Huttunen KM
    Int J Pharm; 2018 Jun; 544(1):91-99. PubMed ID: 29669256
    [TBL] [Abstract][Full Text] [Related]  

  • 2. L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.
    Puris E; Gynther M; Huttunen J; Petsalo A; Huttunen KM
    J Control Release; 2017 Sep; 261():93-104. PubMed ID: 28662899
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth.
    Bothwell PJ; Kron CD; Wittke EF; Czerniak BN; Bode BP
    Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 30029480
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition.
    Uchino H; Kanai Y; Kim DK; Wempe MF; Chairoungdua A; Morimoto E; Anders MW; Endou H
    Mol Pharmacol; 2002 Apr; 61(4):729-37. PubMed ID: 11901210
    [TBL] [Abstract][Full Text] [Related]  

  • 5. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E; Gynther M; Huttunen J; Auriola S; Huttunen KM
    Eur J Pharm Sci; 2019 Mar; 129():99-109. PubMed ID: 30625368
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET.
    Wiriyasermkul P; Nagamori S; Tominaga H; Oriuchi N; Kaira K; Nakao H; Kitashoji T; Ohgaki R; Tanaka H; Endou H; Endo K; Sakurai H; Kanai Y
    J Nucl Med; 2012 Aug; 53(8):1253-61. PubMed ID: 22743251
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.
    Peura L; Malmioja K; Laine K; Leppänen J; Gynther M; Isotalo A; Rautio J
    Mol Pharm; 2011 Oct; 8(5):1857-66. PubMed ID: 21770378
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
    Chien HC; Colas C; Finke K; Springer S; Stoner L; Zur AA; Venteicher B; Campbell J; Hall C; Flint A; Augustyn E; Hernandez C; Heeren N; Hansen L; Anthony A; Bauer J; Fotiadis D; Schlessinger A; Giacomini KM; Thomas AA
    J Med Chem; 2018 Aug; 61(16):7358-7373. PubMed ID: 30048132
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation.
    Kärkkäinen J; Laitinen T; Markowicz-Piasecka M; Montaser A; Lehtonen M; Rautio J; Gynther M; Poso A; Huttunen KM
    Bioorg Chem; 2021 Jul; 112():104921. PubMed ID: 33933805
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).
    Cormerais Y; Massard PA; Vucetic M; Giuliano S; Tambutté E; Durivault J; Vial V; Endou H; Wempe MF; Parks SK; Pouyssegur J
    J Biol Chem; 2018 Feb; 293(8):2877-2887. PubMed ID: 29326164
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1).
    Chen S; Jin C; Ohgaki R; Xu M; Okanishi H; Kanai Y
    Sci Rep; 2024 Feb; 14(1):4651. PubMed ID: 38409393
    [TBL] [Abstract][Full Text] [Related]  

  • 12. L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs).
    Huttunen J; Gynther M; Vellonen KS; Huttunen KM
    Int J Pharm; 2019 Nov; 571():118714. PubMed ID: 31610281
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line.
    Takahashi Y; Nishimura T; Higuchi K; Noguchi S; Tega Y; Kurosawa T; Deguchi Y; Tomi M
    Pharm Res; 2018 Oct; 35(12):246. PubMed ID: 30374619
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).
    Rautio J; Kärkkäinen J; Huttunen KM; Gynther M
    Eur J Pharm Sci; 2015 Jan; 66():36-40. PubMed ID: 25305508
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea.
    Jain-Vakkalagadda B; Dey S; Pal D; Mitra AK
    Invest Ophthalmol Vis Sci; 2003 Jul; 44(7):2919-27. PubMed ID: 12824232
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates.
    Bahrami K; Järvinen J; Laitinen T; Reinisalo M; Honkakoski P; Poso A; Huttunen KM; Rautio J
    Mol Pharm; 2023 Jan; 20(1):206-218. PubMed ID: 36394563
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7.
    Pocasap P; Weerapreeyakul N; Timonen J; Järvinen J; Leppänen J; Kärkkäinen J; Rautio J
    Int J Mol Sci; 2020 Mar; 21(6):. PubMed ID: 32244913
    [TBL] [Abstract][Full Text] [Related]  

  • 18. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia.
    Huttunen J; Peltokangas S; Gynther M; Natunen T; Hiltunen M; Auriola S; Ruponen M; Vellonen KS; Huttunen KM
    Sci Rep; 2019 Sep; 9(1):12860. PubMed ID: 31492955
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.
    Kim DK; Kanai Y; Choi HW; Tangtrongsup S; Chairoungdua A; Babu E; Tachampa K; Anzai N; Iribe Y; Endou H
    Biochim Biophys Acta; 2002 Sep; 1565(1):112-21. PubMed ID: 12225859
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evaluation of amino acid-mustard transport as L-type amino acid transporter 1 (LAT1)-mediated alkylating agents.
    Hosoya K; Kyoko H; Toyooka N; Kato A; Orihashi M; Tomi M; Tachikawa M
    Biol Pharm Bull; 2008 Nov; 31(11):2126-30. PubMed ID: 18981585
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.