BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 29677635)

  • 1. Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2).
    Yu LM; Hu Z; Chen Y; Ravji A; Lopez S; Plescia CB; Yu Q; Yang H; Abdelmalak M; Saha S; Agama K; Kiselev E; Marchand C; Pommier Y; An LK
    Eur J Med Chem; 2018 May; 151():777-796. PubMed ID: 29677635
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft.
    Kossmann BR; Abdelmalak M; Lopez S; Tender G; Yan C; Pommier Y; Marchand C; Ivanov I
    Bioorg Med Chem Lett; 2016 Jul; 26(14):3232-3236. PubMed ID: 27262595
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
    Yang H; Zhu XQ; Wang W; Chen Y; Hu Z; Zhang Y; Hu DX; Yu LM; Agama K; Pommier Y; An LK
    Bioorg Chem; 2021 Jun; 111():104881. PubMed ID: 33839584
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.
    Kont YS; Dutta A; Mallisetty A; Mathew J; Minas T; Kraus C; Dhopeshwarkar P; Kallakury B; Mitra S; Üren A; Adhikari S
    DNA Repair (Amst); 2016 Jul; 43():38-47. PubMed ID: 27235629
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
    Kiselev E; Ravji A; Kankanala J; Xie J; Wang Z; Pommier Y
    DNA Repair (Amst); 2020 Jan; 85():102747. PubMed ID: 31775111
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).
    Kankanala J; Marchand C; Abdelmalak M; Aihara H; Pommier Y; Wang Z
    J Med Chem; 2016 Mar; 59(6):2734-46. PubMed ID: 26910725
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).
    Wang P; Elsayed MSA; Plescia CB; Ravji A; Redon CE; Kiselev E; Marchand C; Zeleznik O; Agama K; Pommier Y; Cushman M
    J Med Chem; 2017 Apr; 60(8):3275-3288. PubMed ID: 28418653
    [TBL] [Abstract][Full Text] [Related]  

  • 8. New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).
    Ribeiro CJA; Kankanala J; Shi K; Kurahashi K; Kiselev E; Ravji A; Pommier Y; Aihara H; Wang Z
    Eur J Pharm Sci; 2018 Jun; 118():67-79. PubMed ID: 29574079
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.
    Marchand C; Abdelmalak M; Kankanala J; Huang SY; Kiselev E; Fesen K; Kurahashi K; Sasanuma H; Takeda S; Aihara H; Wang Z; Pommier Y
    ACS Chem Biol; 2016 Jul; 11(7):1925-33. PubMed ID: 27128689
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
    Ribeiro CJA; Kankanala J; Xie J; Williams J; Aihara H; Wang Z
    Bioorg Med Chem Lett; 2019 Jan; 29(2):257-261. PubMed ID: 30522956
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.
    Laev SS; Salakhutdinov NF; Lavrik OI
    Bioorg Med Chem; 2016 Nov; 24(21):5017-5027. PubMed ID: 27687971
    [TBL] [Abstract][Full Text] [Related]  

  • 12. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
    Zeng Z; Sharma A; Ju L; Murai J; Umans L; Vermeire L; Pommier Y; Takeda S; Huylebroeck D; Caldecott KW; El-Khamisy SF
    Nucleic Acids Res; 2012 Sep; 40(17):8371-80. PubMed ID: 22740648
    [TBL] [Abstract][Full Text] [Related]  

  • 13. New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
    Salomatina OV; Dyrkheeva NS; Popadyuk II; Zakharenko AL; Ilina ES; Komarova NI; Reynisson J; Salakhutdinov NF; Lavrik OI; Volcho KP
    Molecules; 2021 Dec; 27(1):. PubMed ID: 35011303
    [TBL] [Abstract][Full Text] [Related]  

  • 14. [Tyrosyl-DNA phosphodiesterases: potential targets for cancer treatment].
    Hu Z; Wang HW; An LK
    Yao Xue Xue Bao; 2016 Feb; 51(2):215-25. PubMed ID: 29856574
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 4-Benzylideneisoquinoline-1,3(
    Senaweera S; He T; Cui H; Aihara H; Wang Z
    Med Chem Res; 2021 Feb; 30(2):371-386. PubMed ID: 33776385
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
    Sirivolu VR; Vernekar SK; Marchand C; Naumova A; Chergui A; Renaud A; Stephen AG; Chen F; Sham YY; Pommier Y; Wang Z
    J Med Chem; 2012 Oct; 55(20):8671-84. PubMed ID: 23006064
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes.
    Lee KC; Swan RL; Sondka Z; Padget K; Cowell IG; Austin CA
    Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 30011940
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding.
    Shimizu N; Hamada Y; Morozumi R; Yamamoto J; Iwai S; Sugiyama KI; Ide H; Tsuda M
    J Biol Chem; 2023 Aug; 299(8):104988. PubMed ID: 37392847
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.
    Zhang Y; Yang H; Wang FT; Peng X; Liu HY; Li QJ; An LK
    Eur J Med Chem; 2022 Aug; 238():114445. PubMed ID: 35580424
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.
    Rao T; Gao R; Takada S; Al Abo M; Chen X; Walters KJ; Pommier Y; Aihara H
    Nucleic Acids Res; 2016 Dec; 44(21):10201-10215. PubMed ID: 27543075
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.