These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 29693321)

  • 1. Analytical subcloning of a clonal cell line demonstrates cellular heterogeneity that does not impact process consistency or robustness.
    Scarcelli JJ; Hone M; Beal K; Ortega A; Figueroa B; Starkey JA; Anderson K
    Biotechnol Prog; 2018 May; 34(3):602-612. PubMed ID: 29693321
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line.
    Tharmalingam T; Barkhordarian H; Tejeda N; Daris K; Yaghmour S; Yam P; Lu F; Goudar C; Munro T; Stevens J
    Biotechnol Prog; 2018 May; 34(3):613-623. PubMed ID: 29882350
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Antibody expression stability in CHO clonally derived cell lines and their subclones: Role of methylation in phenotypic and epigenetic heterogeneity.
    Patel NA; Anderson CR; Terkildsen SE; Davis RC; Pack LD; Bhargava S; Clarke HRG
    Biotechnol Prog; 2018 May; 34(3):635-649. PubMed ID: 29717549
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality.
    Ko P; Misaghi S; Hu Z; Zhan D; Tsukuda J; Yim M; Sanford M; Shaw D; Shiratori M; Snedecor B; Laird M; Shen A
    Biotechnol Prog; 2018 May; 34(3):624-634. PubMed ID: 29226566
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Retrospective assessment of clonality of a legacy cell line by analytical subcloning of the master cell bank.
    Li GB; Pollard J; Liu R; Stevens RC; Quiroz J; Nelson MC; Manahan M; Murgolo N; Ehrick RS; Wallenstein EJ; Hughes J; Tsao YS; Zhao J; Du Z; Tugcu N; Pollard D
    Biotechnol Prog; 2022 Jan; 38(1):e3215. PubMed ID: 34586757
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Accelerating patient access to novel biologics using stable pool-derived product for non-clinical studies and single clone-derived product for clinical studies.
    Munro TP; Le K; Le H; Zhang L; Stevens J; Soice N; Benchaar SA; Hong RW; Goudar CT
    Biotechnol Prog; 2017 Nov; 33(6):1476-1482. PubMed ID: 29055113
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparative study of therapeutic antibody candidates derived from mini-pool and clonal cell lines.
    Fan L; Rizzi G; Bierilo K; Tian J; Yee JC; Russell R; Das TK
    Biotechnol Prog; 2017 Nov; 33(6):1456-1462. PubMed ID: 28393481
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro-bioreactor system.
    Velugula-Yellela SR; Williams A; Trunfio N; Hsu CJ; Chavez B; Yoon S; Agarabi C
    Biotechnol Prog; 2018 Jan; 34(1):262-270. PubMed ID: 29086492
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally-derived or not.
    Zhou Y; Shaw D; Lam C; Tsukuda J; Yim M; Tang D; Louie S; Laird MW; Snedecor B; Misaghi S
    Biotechnol Prog; 2018 May; 34(3):559-569. PubMed ID: 28941017
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Measuring the aggregation of CHO cells prior to single cell cloning allows a more accurate determination of the probability of clonality.
    Klottrup KJ; Miro-Quesada G; Flack L; Pereda I; Hawley-Nelson P
    Biotechnol Prog; 2018 May; 34(3):593-601. PubMed ID: 28556621
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Utilization of sequence variants as biomarkers to analyze population dynamics in cloned cell lines.
    Lin TJ; Beal KM; DeGruttola HS; Brennan S; Marzilli LA; Anderson K
    Biotechnol Bioeng; 2017 Aug; 114(8):1744-1752. PubMed ID: 28369783
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development and characterization of an automated imaging workflow to generate clonally-derived cell lines for therapeutic proteins.
    Shaw D; Yim M; Tsukuda J; Joly JC; Lin A; Snedecor B; Laird MW; Lang SE
    Biotechnol Prog; 2018 May; 34(3):584-592. PubMed ID: 28960825
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?
    Chusainow J; Yang YS; Yeo JH; Toh PC; Asvadi P; Wong NS; Yap MG
    Biotechnol Bioeng; 2009 Mar; 102(4):1182-96. PubMed ID: 18979540
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bioreactor scale up and protein product quality characterization of piggyBac transposon derived CHO pools.
    Rajendra Y; Balasubramanian S; Peery RB; Swartling JR; McCracken NA; Norris DL; Frye CC; Barnard GC
    Biotechnol Prog; 2017 Mar; 33(2):534-540. PubMed ID: 28188692
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Optimization of cell line development in the GS-CHO expression system using a high-throughput, single cell-based clone selection system.
    Nakamura T; Omasa T
    J Biosci Bioeng; 2015 Sep; 120(3):323-9. PubMed ID: 25792187
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies.
    Hu Z; Hsu W; Pynn A; Ng D; Quicho D; Adem Y; Kwong Z; Mauger B; Joly J; Snedecor B; Laird MW; Andersen DC; Shen A
    Biotechnol Prog; 2017 Nov; 33(6):1449-1455. PubMed ID: 28371489
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Leveraging a CHO cell line toolkit to accelerate biotherapeutics into the clinic.
    Wright C; Alves C; Kshirsagar R; Pieracci J; Estes S
    Biotechnol Prog; 2017 Nov; 33(6):1468-1475. PubMed ID: 28842948
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel Bxb1 integrase RMCE system for high fidelity site-specific integration of mAb expression cassette in CHO Cells.
    Inniss MC; Bandara K; Jusiak B; Lu TK; Weiss R; Wroblewska L; Zhang L
    Biotechnol Bioeng; 2017 Aug; 114(8):1837-1846. PubMed ID: 28186334
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl-drug conjugation process.
    Hippach MB; Schwartz I; Pei J; Huynh J; Kawai Y; Zhu MM
    Biotechnol Prog; 2018 Nov; 34(6):1427-1437. PubMed ID: 30207642
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effective and efficient characterization of Chinese hamster ovary production cell lines using automated intracellular staining and statistical modeling.
    Krebs LE; Bowden DM; Bray CM; Shaw MM; Frye CC
    Biotechnol Prog; 2018 May; 34(3):570-583. PubMed ID: 29882242
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.