252 related articles for article (PubMed ID: 29699940)
1. Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.
Biscans A; Haraszti RA; Echeverria D; Miller R; Didiot MC; Nikan M; Roux L; Aronin N; Khvorova A
Mol Ther; 2018 Jun; 26(6):1520-1528. PubMed ID: 29699940
[TBL] [Abstract][Full Text] [Related]
2. Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
Haraszti RA; Miller R; Didiot MC; Biscans A; Alterman JF; Hassler MR; Roux L; Echeverria D; Sapp E; DiFiglia M; Aronin N; Khvorova A
Mol Ther; 2018 Aug; 26(8):1973-1982. PubMed ID: 29937418
[TBL] [Abstract][Full Text] [Related]
3. The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.
Biscans A; Coles A; Echeverria D; Khvorova A
J Control Release; 2019 May; 302():116-125. PubMed ID: 30940496
[TBL] [Abstract][Full Text] [Related]
4. Loading of Extracellular Vesicles with Hydrophobically Modified siRNAs.
Didiot MC; Haraszti RA; Aronin N; Khvorova A
Methods Mol Biol; 2018; 1740():199-214. PubMed ID: 29388146
[TBL] [Abstract][Full Text] [Related]
5. Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Osborn MF; Coles AH; Biscans A; Haraszti RA; Roux L; Davis S; Ly S; Echeverria D; Hassler MR; Godinho BMDC; Nikan M; Khvorova A
Nucleic Acids Res; 2019 Feb; 47(3):1070-1081. PubMed ID: 30535404
[TBL] [Abstract][Full Text] [Related]
6. Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
Biscans A; Coles A; Haraszti R; Echeverria D; Hassler M; Osborn M; Khvorova A
Nucleic Acids Res; 2019 Feb; 47(3):1082-1096. PubMed ID: 30544191
[TBL] [Abstract][Full Text] [Related]
7. Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles.
O'Loughlin AJ; Mäger I; de Jong OG; Varela MA; Schiffelers RM; El Andaloussi S; Wood MJA; Vader P
Mol Ther; 2017 Jul; 25(7):1580-1587. PubMed ID: 28392161
[TBL] [Abstract][Full Text] [Related]
8. Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo.
Biscans A; Ly S; McHugh N; Cooper DA; Khvorova A
J Control Release; 2022 Sep; 349():831-843. PubMed ID: 35917865
[TBL] [Abstract][Full Text] [Related]
9. Systemic delivery of stable siRNA-encapsulating lipid vesicles: optimization, biodistribution, and tumor suppression.
Dar GH; Gopal V; Rao NM
Mol Pharm; 2015 Feb; 12(2):610-20. PubMed ID: 25545110
[TBL] [Abstract][Full Text] [Related]
10. Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA.
McCann J; Sosa-Miranda CD; Guo H; Reshke R; Savard A; Zardini Buzatto A; Taylor JA; Li L; Gibbings DJ
J Extracell Vesicles; 2022 Oct; 11(10):e12220. PubMed ID: 36214496
[TBL] [Abstract][Full Text] [Related]
11. Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach.
Thanki K; Zeng X; Justesen S; Tejlmann S; Falkenberg E; Van Driessche E; Mørck Nielsen H; Franzyk H; Foged C
Eur J Pharm Biopharm; 2017 Nov; 120():22-33. PubMed ID: 28756280
[TBL] [Abstract][Full Text] [Related]
12. Small interfering RNA nunchucks with a hydrophobic linker for efficient intracellular delivery.
Jo SD; Kim JS; Joe CO; Mok H; Nam YS
Macromol Biosci; 2014 Feb; 14(2):195-201. PubMed ID: 24106091
[TBL] [Abstract][Full Text] [Related]
13. Engineered small extracellular vesicle-mediated NOX4 siRNA delivery for targeted therapy of cardiac hypertrophy.
Kang JY; Mun D; Chun Y; Park DS; Kim H; Yun N; Joung B
J Extracell Vesicles; 2023 Oct; 12(10):e12371. PubMed ID: 37795828
[TBL] [Abstract][Full Text] [Related]
14. Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency.
Kubo T; Nishimura Y; Sato Y; Yanagihara K; Seyama T
ACS Chem Biol; 2021 Jan; 16(1):150-164. PubMed ID: 33346648
[TBL] [Abstract][Full Text] [Related]
15. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA.
Bouxsein NF; McAllister CS; Ewert KK; Samuel CE; Safinya CR
Biochemistry; 2007 Apr; 46(16):4785-92. PubMed ID: 17391006
[TBL] [Abstract][Full Text] [Related]
16. Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues.
Bordas M; Genard G; Ohl S; Nessling M; Richter K; Roider T; Dietrich S; Maaß KK; Seiffert M
Int J Mol Sci; 2020 Aug; 21(15):. PubMed ID: 32759826
[TBL] [Abstract][Full Text] [Related]
17. 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Haraszti RA; Roux L; Coles AH; Turanov AA; Alterman JF; Echeverria D; Godinho BMDC; Aronin N; Khvorova A
Nucleic Acids Res; 2017 Jul; 45(13):7581-7592. PubMed ID: 28591791
[TBL] [Abstract][Full Text] [Related]
18. Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo.
Sato Y; Hashiba K; Sasaki K; Maeki M; Tokeshi M; Harashima H
J Control Release; 2019 Feb; 295():140-152. PubMed ID: 30610950
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3'-termini.
Ueno Y; Kawada K; Naito T; Shibata A; Yoshikawa K; Kim HS; Wataya Y; Kitade Y
Bioorg Med Chem; 2008 Aug; 16(16):7698-704. PubMed ID: 18644731
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3'-termini.
Ueno Y; Kawada K; Shibata A; Yoshikawa K; Wataya Y; Kitade Y
Nucleic Acids Symp Ser (Oxf); 2008; (52):503-4. PubMed ID: 18776474
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]