BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 29706533)

  • 1. K-Ras Populates Conformational States Differently from Its Isoform H-Ras and Oncogenic Mutant K-RasG12D.
    Parker JA; Volmar AY; Pavlopoulos S; Mattos C
    Structure; 2018 Jun; 26(6):810-820.e4. PubMed ID: 29706533
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.
    Spoerner M; Hozsa C; Poetzl JA; Reiss K; Ganser P; Geyer M; Kalbitzer HR
    J Biol Chem; 2010 Dec; 285(51):39768-78. PubMed ID: 20937837
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.
    Johnson CW; Reid D; Parker JA; Salter S; Knihtila R; Kuzmic P; Mattos C
    J Biol Chem; 2017 Aug; 292(31):12981-12993. PubMed ID: 28630043
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant.
    Wittinghofer F; Krengel U; John J; Kabsch W; Pai EF
    Environ Health Perspect; 1991 Jun; 93():11-5. PubMed ID: 1773783
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
    Xu S; Long BN; Boris GH; Chen A; Ni S; Kennedy MA
    Acta Crystallogr D Struct Biol; 2017 Dec; 73(Pt 12):970-984. PubMed ID: 29199977
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conformational Dynamics Allows Sampling of an "Active-like" State by Oncogenic K-Ras-GDP.
    Grudzien P; Jang H; Leschinsky N; Nussinov R; Gaponenko V
    J Mol Biol; 2022 Sep; 434(17):167695. PubMed ID: 35752212
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for conformational dynamics of GTP-bound Ras protein.
    Shima F; Ijiri Y; Muraoka S; Liao J; Ye M; Araki M; Matsumoto K; Yamamoto N; Sugimoto T; Yoshikawa Y; Kumasaka T; Yamamoto M; Tamura A; Kataoka T
    J Biol Chem; 2010 Jul; 285(29):22696-705. PubMed ID: 20479006
    [TBL] [Abstract][Full Text] [Related]  

  • 8. NMR
    Yuan C; Hansen AL; Bruschweiler-Li L; Brüschweiler R
    Biomol NMR Assign; 2024 Jun; 18(1):7-13. PubMed ID: 37948018
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.
    Sayyed-Ahmad A; Prakash P; Gorfe AA
    Proteins; 2017 Sep; 85(9):1618-1632. PubMed ID: 28498561
    [TBL] [Abstract][Full Text] [Related]  

  • 10. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
    Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
    J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.
    Geyer M; Schweins T; Herrmann C; Prisner T; Wittinghofer A; Kalbitzer HR
    Biochemistry; 1996 Aug; 35(32):10308-20. PubMed ID: 8756686
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants.
    Muraoka S; Shima F; Araki M; Inoue T; Yoshimoto A; Ijiri Y; Seki N; Tamura A; Kumasaka T; Yamamoto M; Kataoka T
    FEBS Lett; 2012 Jun; 586(12):1715-8. PubMed ID: 22584058
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras.
    Miller AF; Halkides CJ; Redfield AG
    Biochemistry; 1993 Jul; 32(29):7367-76. PubMed ID: 8338834
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21.
    Wittinghofer A; Franken SM; Scheidig AJ; Rensland H; Lautwein A; Pai EF; Goody RS
    Ciba Found Symp; 1993; 176():6-21; discussion 21-7. PubMed ID: 8299426
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein.
    Matsumoto S; Taniguchi-Tamura H; Araki M; Kawamura T; Miyamoto R; Tsuda C; Shima F; Kumasaka T; Okuno Y; Kataoka T
    Biochem Biophys Res Commun; 2021 Aug; 565():85-90. PubMed ID: 34102474
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The higher level of complexity of K-Ras4B activation at the membrane.
    Jang H; Banerjee A; Chavan TS; Lu S; Zhang J; Gaponenko V; Nussinov R
    FASEB J; 2016 Apr; 30(4):1643-55. PubMed ID: 26718888
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparison of the average structures, from molecular dynamics, of complexes of GTPase activating protein (GAP) with oncogenic and wild-type ras-p21: identification of potential effector domains.
    Chen JM; Friedman FK; Brandt-Rauf PW; Pincus MR; Chie L
    J Protein Chem; 2002 Jul; 21(5):349-59. PubMed ID: 12206509
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
    Franken SM; Scheidig AJ; Krengel U; Rensland H; Lautwein A; Geyer M; Scheffzek K; Goody RS; Kalbitzer HR; Pai EF
    Biochemistry; 1993 Aug; 32(33):8411-20. PubMed ID: 8357792
    [TBL] [Abstract][Full Text] [Related]  

  • 19. X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
    Privé GG; Milburn MV; Tong L; de Vos AM; Yamaizumi Z; Nishimura S; Kim SH
    Proc Natl Acad Sci U S A; 1992 Apr; 89(8):3649-53. PubMed ID: 1565661
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
    Gentile DR; Rathinaswamy MK; Jenkins ML; Moss SM; Siempelkamp BD; Renslo AR; Burke JE; Shokat KM
    Cell Chem Biol; 2017 Dec; 24(12):1455-1466.e14. PubMed ID: 29033317
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.