BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

322 related articles for article (PubMed ID: 29737249)

  • 1. Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development.
    Swingle MR; Honkanen RE
    Curr Med Chem; 2019; 26(15):2634-2660. PubMed ID: 29737249
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
    Chattopadhyay D; Swingle MR; Salter EA; Wood E; D'Arcy B; Zivanov C; Abney K; Musiyenko A; Rusin SF; Kettenbach A; Yet L; Schroeder CE; Golden JE; Dunham WH; Gingras AC; Banerjee S; Forbes D; Wierzbicki A; Honkanen RE
    Biochem Pharmacol; 2016 Jun; 109():14-26. PubMed ID: 27002182
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.
    Swingle MR; Amable L; Lawhorn BG; Buck SB; Burke CP; Ratti P; Fischer KL; Boger DL; Honkanen RE
    J Pharmacol Exp Ther; 2009 Oct; 331(1):45-53. PubMed ID: 19592665
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Plant protein phosphatases: What do we know about their mechanism of action?
    Bheri M; Mahiwal S; Sanyal SK; Pandey GK
    FEBS J; 2021 Feb; 288(3):756-785. PubMed ID: 32542989
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The structure and mechanism of protein phosphatases: insights into catalysis and regulation.
    Barford D; Das AK; Egloff MP
    Annu Rev Biophys Biomol Struct; 1998; 27():133-64. PubMed ID: 9646865
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins.
    Pereira SR; Vasconcelos VM; Antunes A
    Crit Rev Toxicol; 2011 Feb; 41(2):83-110. PubMed ID: 21288162
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Computational study of the covalent bonding of microcystins to cysteine residues--a reaction involved in the inhibition of the PPP family of protein phosphatases.
    Pereira SR; Vasconcelos VM; Antunes A
    FEBS J; 2013 Jan; 280(2):674-80. PubMed ID: 22177231
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A molecular modeling analysis of the binding interactions between the okadaic acid class of natural product inhibitors and the Ser-Thr phosphatases, PP1 and PP2A.
    Gauss CM; Sheppeck JE; Nairn AC; Chamberlin R
    Bioorg Med Chem; 1997 Sep; 5(9):1751-73. PubMed ID: 9354231
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular mechanisms underlying inhibition of protein phosphatases by marine toxins.
    Dawson JF; Holmes CF
    Front Biosci; 1999 Oct; 4():D646-58. PubMed ID: 10502549
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.
    Kamada R; Kudoh F; Ito S; Tani I; Janairo JIB; Omichinski JG; Sakaguchi K
    Pharmacol Ther; 2020 Nov; 215():107622. PubMed ID: 32650009
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular modeling of the catalytic domain of serine/threonine phosphatase-1 with the Zn2+ and Mn2+ di-nuclear ion centers in the active site.
    Wozniak E; OƂdziej S; Ciarkowski J
    Comput Chem; 2000 May; 24(3-4):381-90. PubMed ID: 10816008
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?
    Honkanen RE; Golden T
    Curr Med Chem; 2002 Nov; 9(22):2055-75. PubMed ID: 12369870
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The 35 kDa acid metallophosphatase of the frog Rana esculenta liver: studies on its cellular localization and protein phosphatase activity.
    Szalewicz A; Strzelczyk B; Sopel M; Kubicz A
    Acta Biochim Pol; 2003; 50(2):555-66. PubMed ID: 12833181
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors.
    Connor JH; Kleeman T; Barik S; Honkanen RE; Shenolikar S
    J Biol Chem; 1999 Aug; 274(32):22366-72. PubMed ID: 10428807
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Protein phosphatases regulate DNA-dependent protein kinase activity.
    Douglas P; Moorhead GB; Ye R; Lees-Miller SP
    J Biol Chem; 2001 Jun; 276(22):18992-8. PubMed ID: 11376007
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.
    Kitatani K; Idkowiak-Baldys J; Hannun YA
    J Biol Chem; 2007 Jul; 282(28):20647-56. PubMed ID: 17504762
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Viewing serine/threonine protein phosphatases through the eyes of drug designers.
    Zhang M; Yogesha SD; Mayfield JE; Gill GN; Zhang Y
    FEBS J; 2013 Oct; 280(19):4739-60. PubMed ID: 23937612
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases.
    Lad C; Williams NH; Wolfenden R
    Proc Natl Acad Sci U S A; 2003 May; 100(10):5607-10. PubMed ID: 12721374
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding.
    Maynes JT; Perreault KR; Cherney MM; Luu HA; James MN; Holmes CF
    J Biol Chem; 2004 Oct; 279(41):43198-206. PubMed ID: 15280359
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.
    Lyons SP; Jenkins NP; Nasa I; Choy MS; Adamo ME; Page R; Peti W; Moorhead GB; Kettenbach AN
    Mol Cell Proteomics; 2018 Dec; 17(12):2448-2461. PubMed ID: 30228194
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.