BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

388 related articles for article (PubMed ID: 29737445)

  • 1. A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery.
    Cholko T; Chen W; Tang Z; Chang CA
    J Comput Aided Mol Des; 2018 Jun; 32(6):671-685. PubMed ID: 29737445
    [TBL] [Abstract][Full Text] [Related]  

  • 2. All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC.
    Xu W; Amire-Brahimi B; Xie XJ; Huang L; Ji JY
    Comput Biol Chem; 2014 Aug; 51():1-11. PubMed ID: 24754906
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Highlighting the Major Role of Cyclin C in Cyclin-Dependent Kinase 8 Activity through Molecular Dynamics Simulations.
    Ziada S; Diharce J; Serillon D; Bonnet P; Aci-Sèche S
    Int J Mol Sci; 2024 May; 25(10):. PubMed ID: 38791449
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.
    Schneider EV; Böttcher J; Blaesse M; Neumann L; Huber R; Maskos K
    J Mol Biol; 2011 Sep; 412(2):251-66. PubMed ID: 21806996
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of CDK8/CycC Ligands with a New Virtual Screening Tool.
    Chen W; Ren X; Chang CA
    ChemMedChem; 2019 Jan; 14(1):107-118. PubMed ID: 30403831
    [TBL] [Abstract][Full Text] [Related]  

  • 6. All-Atomic Molecular Dynamic Studies of Human and
    Xu W; Xie XJ; Faust AK; Liu M; Li X; Chen F; Naquin AA; Walton AC; Kishbaugh PW; Ji JY
    Int J Mol Sci; 2020 Oct; 21(20):. PubMed ID: 33053834
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-kinetic relationship study of CDK8/CycC specific compounds.
    Schneider EV; Böttcher J; Huber R; Maskos K; Neumann L
    Proc Natl Acad Sci U S A; 2013 May; 110(20):8081-6. PubMed ID: 23630251
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
    J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cyclin C influences the timing of mitosis in fission yeast.
    Banyai G; Szilagyi Z; Baraznenok V; Khorosjutina O; Gustafsson CM
    Mol Biol Cell; 2017 Jul; 28(13):1738-1744. PubMed ID: 28515143
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription.
    Li X; Liu M; Ren X; Loncle N; Wang Q; Hemba-Waduge RU; Yu SH; Boube M; Bourbon HG; Ni JQ; Ji JY
    PLoS Genet; 2020 May; 16(5):e1008832. PubMed ID: 32463833
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular dynamics simulation and free energy calculation studies of kinase inhibitors binding to active and inactive conformations of VEGFR-2.
    Wu X; Wan S; Wang G; Jin H; Li Z; Tian Y; Zhu Z; Zhang J
    J Mol Graph Model; 2015 Mar; 56():103-12. PubMed ID: 25594497
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Binding patterns and structure-activity relationship of CDK8 inhibitors.
    Ma D; Chen X; Shen XB; Sheng LQ; Liu XH
    Bioorg Chem; 2020 Mar; 96():103624. PubMed ID: 32078847
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
    Xie XJ; Hsu FN; Gao X; Xu W; Ni JQ; Xing Y; Huang L; Hsiao HC; Zheng H; Wang C; Zheng Y; Xiaoli AM; Yang F; Bondos SE; Ji JY
    PLoS Biol; 2015 Jul; 13(7):e1002207. PubMed ID: 26222308
    [TBL] [Abstract][Full Text] [Related]  

  • 14. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
    Feng D; Youn DY; Zhao X; Gao Y; Quinn WJ; Xiaoli AM; Sun Y; Birnbaum MJ; Pessin JE; Yang F
    PLoS One; 2015; 10(6):e0126240. PubMed ID: 26042770
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dysregulation of CDK8 and Cyclin C in tumorigenesis.
    Xu W; Ji JY
    J Genet Genomics; 2011 Oct; 38(10):439-52. PubMed ID: 22035865
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mediator kinase module and human tumorigenesis.
    Clark AD; Oldenbroek M; Boyer TG
    Crit Rev Biochem Mol Biol; 2015; 50(5):393-426. PubMed ID: 26182352
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.
    Wang T; Yang Z; Zhang Y; Yan W; Wang F; He L; Zhou Y; Chen L
    Eur J Med Chem; 2017 Mar; 129():275-286. PubMed ID: 28231524
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8.
    Callegari D; Lodola A; Pala D; Rivara S; Mor M; Rizzi A; Capelli AM
    J Chem Inf Model; 2017 Feb; 57(2):159-169. PubMed ID: 28080056
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
    Xi M; Chen T; Wu C; Gao X; Wu Y; Luo X; Du K; Yu L; Cai T; Shen R; Sun H
    Eur J Med Chem; 2019 Feb; 164():77-91. PubMed ID: 30594029
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations.
    Shen M; Zhou S; Li Y; Pan P; Zhang L; Hou T
    Mol Biosyst; 2013 Mar; 9(3):361-74. PubMed ID: 23340525
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.