140 related articles for article (PubMed ID: 29764744)
1. Effective gene silencing activity of prodrug-type 2'-O-methyldithiomethyl siRNA compared with non-prodrug-type 2'-O-methyl siRNA.
Hayashi J; Nishigaki M; Ochi Y; Wada SI; Wada F; Nakagawa O; Obika S; Harada-Shiba M; Urata H
Bioorg Med Chem Lett; 2018 Jul; 28(12):2171-2174. PubMed ID: 29764744
[TBL] [Abstract][Full Text] [Related]
2. Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency.
Hayashi J; Ochi Y; Senpuku K; Wada SI; Wada F; Harada-Shiba M; Urata H
Bioorg Med Chem; 2024 Apr; 104():117693. PubMed ID: 38552598
[TBL] [Abstract][Full Text] [Related]
3. Gene silencing by 2'-O-methyldithiomethyl-modified siRNA, a prodrug-type siRNA responsive to reducing environment.
Ochi Y; Imai M; Nakagawa O; Hayashi J; Wada SI; Urata H
Bioorg Med Chem Lett; 2016 Feb; 26(3):845-848. PubMed ID: 26755395
[TBL] [Abstract][Full Text] [Related]
4. Syntheses of prodrug-type 2'-O-methyldithiomethyl oligonucleotides modified at natural four nucleoside residues and their conversions into natural 2'-hydroxy oligonucleotides under reducing condition.
Hayashi J; Ochi Y; Morita Y; Soubou K; Ohtomo Y; Nishigaki M; Tochiyama Y; Nakagawa O; Wada SI; Urata H
Bioorg Med Chem; 2018 Dec; 26(22):5838-5844. PubMed ID: 30420326
[TBL] [Abstract][Full Text] [Related]
5. 2'-O-methyl-modified anti-MDR1 fork-siRNA duplexes exhibiting high nuclease resistance and prolonged silencing activity.
Petrova Kruglova NS; Meschaninova MI; Venyaminova AG; Zenkova MA; Vlassov VV; Chernolovskaya EL
Oligonucleotides; 2010 Dec; 20(6):297-308. PubMed ID: 21028964
[TBL] [Abstract][Full Text] [Related]
6. Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity.
Kubo T; Yanagihara K; Takei Y; Mihara K; Morita Y; Seyama T
Mol Pharm; 2011 Dec; 8(6):2193-203. PubMed ID: 21985606
[TBL] [Abstract][Full Text] [Related]
7. Effects of conformational alteration induced by D-/L-isonucleoside incorporation in siRNA on their stability in serum and silencing activity.
Huang Y; Chen Z; Chen Y; Zhang H; Zhang Y; Zhao Y; Yang Z; Zhang L
Bioconjug Chem; 2013 Jun; 24(6):951-9. PubMed ID: 23682837
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, gene silencing, and molecular modeling studies of 4'-C-aminomethyl-2'-O-methyl modified small interfering RNAs.
Gore KR; Nawale GN; Harikrishna S; Chittoor VG; Pandey SK; Höbartner C; Patankar S; Pradeepkumar PI
J Org Chem; 2012 Apr; 77(7):3233-45. PubMed ID: 22372696
[TBL] [Abstract][Full Text] [Related]
9. Selective protection of nuclease-sensitive sites in siRNA prolongs silencing effect.
Volkov AA; Kruglova NS; Meschaninova MI; Venyaminova AG; Zenkova MA; Vlassov VV; Chernolovskaya EL
Oligonucleotides; 2009 Jun; 19(2):191-202. PubMed ID: 19344210
[TBL] [Abstract][Full Text] [Related]
10. Silencing activity of 2'-O-methyl modified anti-MDR1 siRNAs with mismatches in the central part of the duplexes.
Petrova NS; Meschaninova MI; Venyaminova AG; Zenkova MA; Vlassov VV; Chernolovskaya EL
FEBS Lett; 2011 Jul; 585(14):2352-6. PubMed ID: 21704032
[TBL] [Abstract][Full Text] [Related]
11. 5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.
Zlatev I; Foster DJ; Liu J; Charisse K; Brigham B; Parmar RG; Jadhav V; Maier MA; Rajeev KG; Egli M; Manoharan M
ACS Chem Biol; 2016 Apr; 11(4):953-60. PubMed ID: 26675211
[TBL] [Abstract][Full Text] [Related]
12. Isonucleotide incorporation into middle and terminal siRNA duplexes exhibits high gene silencing efficacy and nuclease resistance.
Ma Y; Liu S; Wang Y; Zhao Y; Huang Y; Zhong L; Guan Z; Zhang L; Yang Z
Org Biomol Chem; 2017 Jun; 15(24):5161-5170. PubMed ID: 28585968
[TBL] [Abstract][Full Text] [Related]
13. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing.
Harborth J; Elbashir SM; Vandenburgh K; Manninga H; Scaringe SA; Weber K; Tuschl T
Antisense Nucleic Acid Drug Dev; 2003 Apr; 13(2):83-105. PubMed ID: 12804036
[TBL] [Abstract][Full Text] [Related]
14. Syntheses of prodrug-type phosphotriester oligonucleotides responsive to intracellular reducing environment for improvement of cell membrane permeability and nuclease resistance.
Hayashi J; Samezawa Y; Ochi Y; Wada SI; Urata H
Bioorg Med Chem Lett; 2017 Jul; 27(14):3135-3138. PubMed ID: 28532670
[TBL] [Abstract][Full Text] [Related]
15. Design of nuclease-resistant fork-like small interfering RNA (fsiRNA).
Chernolovskaya EL; Zenkova MA
Methods Mol Biol; 2013; 942():153-68. PubMed ID: 23027050
[TBL] [Abstract][Full Text] [Related]
16. Structure Tuning of Cationic Oligospermine-siRNA Conjugates for Carrier-Free Gene Silencing.
Nothisen M; Bagilet J; Behr JP; Remy JS; Kotera M
Mol Pharm; 2016 Aug; 13(8):2718-28. PubMed ID: 27398779
[TBL] [Abstract][Full Text] [Related]
17. Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells.
Varley AJ; Hammill ML; Salim L; Desaulniers JP
Nucleic Acid Ther; 2020 Aug; 30(4):229-236. PubMed ID: 32175808
[TBL] [Abstract][Full Text] [Related]
18. 2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.
Davis SM; Sousa J; Vangjeli L; Hassler MR; Echeverria D; Knox E; Turanov AA; Alterman JF; Khvorova A
Mol Ther Nucleic Acids; 2020 Sep; 21():266-277. PubMed ID: 32610253
[TBL] [Abstract][Full Text] [Related]
19. 4'-
Gangopadhyay S; Das G; Gupta S; Ghosh A; Bagale SS; Roy PK; Mandal M; Harikrishna S; Sinha S; Gore KR
J Org Chem; 2024 Mar; 89(6):3747-3768. PubMed ID: 38394362
[TBL] [Abstract][Full Text] [Related]
20. Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs.
Hamada M; Ohtsuka T; Kawaida R; Koizumi M; Morita K; Furukawa H; Imanishi T; Miyagishi M; Taira K
Antisense Nucleic Acid Drug Dev; 2002 Oct; 12(5):301-9. PubMed ID: 12477280
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]