247 related articles for article (PubMed ID: 29769258)
1. Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
Iwai K; Yaguchi M; Nishimura K; Yamamoto Y; Tamura T; Nakata D; Dairiki R; Kawakita Y; Mizojiri R; Ito Y; Asano M; Maezaki H; Nakayama Y; Kaishima M; Hayashi K; Teratani M; Miyakawa S; Iwatani M; Miyamoto M; Klein MG; Lane W; Snell G; Tjhen R; He X; Pulukuri S; Nomura T
EMBO Mol Med; 2018 Jun; 10(6):. PubMed ID: 29769258
[TBL] [Abstract][Full Text] [Related]
2. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing.
Araki S; Dairiki R; Nakayama Y; Murai A; Miyashita R; Iwatani M; Nomura T; Nakanishi O
PLoS One; 2015; 10(1):e0116929. PubMed ID: 25581376
[TBL] [Abstract][Full Text] [Related]
3. CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Funnell T; Tasaki S; Oloumi A; Araki S; Kong E; Yap D; Nakayama Y; Hughes CS; Cheng SG; Tozaki H; Iwatani M; Sasaki S; Ohashi T; Miyazaki T; Morishita N; Morishita D; Ogasawara-Shimizu M; Ohori M; Nakao S; Karashima M; Sano M; Murai A; Nomura T; Uchiyama N; Kawamoto T; Hara R; Nakanishi O; Shumansky K; Rosner J; Wan A; McKinney S; Morin GB; Nakanishi A; Shah S; Toyoshiba H; Aparicio S
Nat Commun; 2017 Feb; 8(1):7. PubMed ID: 28232751
[TBL] [Abstract][Full Text] [Related]
4. Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.
Murai A; Ebara S; Sasaki S; Ohashi T; Miyazaki T; Nomura T; Araki S
PLoS One; 2020; 15(10):e0240718. PubMed ID: 33064779
[TBL] [Abstract][Full Text] [Related]
5. Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease.
Jain P; Karthikeyan C; Moorthy NS; Waiker DK; Jain AK; Trivedi P
Curr Drug Targets; 2014 May; 15(5):539-50. PubMed ID: 24568585
[TBL] [Abstract][Full Text] [Related]
6. The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models.
Tam BY; Chiu K; Chung H; Bossard C; Nguyen JD; Creger E; Eastman BW; Mak CC; Ibanez M; Ghias A; Cahiwat J; Do L; Cho S; Nguyen J; Deshmukh V; Stewart J; Chen CW; Barroga C; Dellamary L; Kc SK; Phalen TJ; Hood J; Cha S; Yazici Y
Cancer Lett; 2020 Mar; 473():186-197. PubMed ID: 31560935
[TBL] [Abstract][Full Text] [Related]
7. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
Walter A; Chaikuad A; Helmer R; Loaëc N; Preu L; Ott I; Knapp S; Meijer L; Kunick C
PLoS One; 2018; 13(5):e0196761. PubMed ID: 29723265
[TBL] [Abstract][Full Text] [Related]
8. Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid.
Jiang K; Patel NA; Watson JE; Apostolatos H; Kleiman E; Hanson O; Hagiwara M; Cooper DR
Endocrinology; 2009 May; 150(5):2087-97. PubMed ID: 19116344
[TBL] [Abstract][Full Text] [Related]
9. Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.
Lee JY; Yun JS; Kim WK; Chun HS; Jin H; Cho S; Chang JH
Biomed Res Int; 2019; 2019():6125068. PubMed ID: 31531359
[TBL] [Abstract][Full Text] [Related]
10. Development of Cdc2-like Kinase 2 Inhibitors: Achievements and Future Directions.
Qin Z; Qin L; Feng X; Li Z; Bian J
J Med Chem; 2021 Sep; 64(18):13191-13211. PubMed ID: 34519506
[TBL] [Abstract][Full Text] [Related]
11. The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
Riggs JR; Nagy M; Elsner J; Erdman P; Cashion D; Robinson D; Harris R; Huang D; Tehrani L; Deyanat-Yazdi G; Narla RK; Peng X; Tran T; Barnes L; Miller T; Katz J; Tang Y; Chen M; Moghaddam MF; Bahmanyar S; Pagarigan B; Delker S; LeBrun L; Chamberlain PP; Calabrese A; Canan SS; Leftheris K; Zhu D; Boylan JF
J Med Chem; 2017 Nov; 60(21):8989-9002. PubMed ID: 28991472
[TBL] [Abstract][Full Text] [Related]
12. Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Coombs TC; Tanega C; Shen M; Wang JL; Auld DS; Gerritz SW; Schoenen FJ; Thomas CJ; Aubé J
Bioorg Med Chem Lett; 2013 Jun; 23(12):3654-61. PubMed ID: 23642479
[TBL] [Abstract][Full Text] [Related]
13. An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.
Hook KE; Garza SJ; Lira ME; Ching KA; Lee NV; Cao J; Yuan J; Ye J; Ozeck M; Shi ST; Zheng X; Rejto PA; Kan JL; Christensen JG; Pavlicek A
Mol Cancer Ther; 2012 Mar; 11(3):710-9. PubMed ID: 22222631
[TBL] [Abstract][Full Text] [Related]
14. Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G
Zhu D; Xu S; Deyanat-Yazdi G; Peng SX; Barnes LA; Narla RK; Tran T; Mikolon D; Ning Y; Shi T; Jiang N; Raymon HK; Riggs JR; Boylan JF
Mol Cancer Ther; 2018 Aug; 17(8):1727-1738. PubMed ID: 29866747
[TBL] [Abstract][Full Text] [Related]
15. In silico identification of a novel Cdc2-like kinase 2 (CLK2) inhibitor in triple negative breast cancer.
Huang CC; Hsu CM; Chao MW; Hsu KC; Lin TE; Yen SC; Tu HJ; Pan SL
Protein Sci; 2024 Jun; 33(6):e5004. PubMed ID: 38723164
[TBL] [Abstract][Full Text] [Related]
16. Manipulation of alternative splicing by a newly developed inhibitor of Clks.
Muraki M; Ohkawara B; Hosoya T; Onogi H; Koizumi J; Koizumi T; Sumi K; Yomoda J; Murray MV; Kimura H; Furuichi K; Shibuya H; Krainer AR; Suzuki M; Hagiwara M
J Biol Chem; 2004 Jun; 279(23):24246-54. PubMed ID: 15010457
[TBL] [Abstract][Full Text] [Related]
17. X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.
Kallen J; Bergsdorf C; Arnaud B; Bernhard M; Brichet M; Cobos-Correa A; Elhajouji A; Freuler F; Galimberti I; Guibourdenche C; Haenni S; Holzinger S; Hunziker J; Izaac A; Kaufmann M; Leder L; Martus HJ; von Matt P; Polyakov V; Roethlisberger P; Roma G; Stiefl N; Uteng M; Lerchner A
ChemMedChem; 2018 Sep; 13(18):1997-2007. PubMed ID: 29985556
[TBL] [Abstract][Full Text] [Related]
18. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A.
Yomoda J; Muraki M; Kataoka N; Hosoya T; Suzuki M; Hagiwara M; Kimura H
Genes Cells; 2008 Mar; 13(3):233-44. PubMed ID: 18298798
[TBL] [Abstract][Full Text] [Related]
19. Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers.
Phillips JW; Pan Y; Tsai BL; Xie Z; Demirdjian L; Xiao W; Yang HT; Zhang Y; Lin CH; Cheng D; Hu Q; Liu S; Black DL; Witte ON; Xing Y
Proc Natl Acad Sci U S A; 2020 Mar; 117(10):5269-5279. PubMed ID: 32086391
[TBL] [Abstract][Full Text] [Related]
20. The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation.
Nayler O; Schnorrer F; Stamm S; Ullrich A
J Biol Chem; 1998 Dec; 273(51):34341-8. PubMed ID: 9852100
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
