BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 29783765)

  • 1. 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.
    Asquith CRM; Godoi PH; Couñago RM; Laitinen T; Scott JW; Langendorf CG; Oakhill JS; Drewry DH; Zuercher WJ; Koutentis PA; Willson TM; Kalogirou AS
    Molecules; 2018 May; 23(5):. PubMed ID: 29783765
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
    Eduful BJ; O'Byrne SN; Temme L; Asquith CRM; Liang Y; Picado A; Pilotte JR; Hossain MA; Wells CI; Zuercher WJ; Catta-Preta CMC; Zonzini Ramos P; Santiago AS; Couñago RM; Langendorf CG; Nay K; Oakhill JS; Pulliam TL; Lin C; Awad D; Willson TM; Frigo DE; Scott JW; Drewry DH
    J Med Chem; 2021 Aug; 64(15):10849-10877. PubMed ID: 34264658
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Binding and structural analyses of potent inhibitors of the human Ca
    Profeta GS; Dos Reis CV; Santiago ADS; Godoi PHC; Fala AM; Wells CI; Sartori R; Salmazo APT; Ramos PZ; Massirer KB; Elkins JM; Drewry DH; Gileadi O; Couñago RM
    Sci Rep; 2019 Nov; 9(1):16452. PubMed ID: 31712618
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.
    Santiago ADS; Couñago RM; Ramos PZ; Godoi PHC; Massirer KB; Gileadi O; Elkins JM
    Sci Rep; 2018 Oct; 8(1):14800. PubMed ID: 30287839
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2.
    Gerner L; Munack S; Temmerman K; Lawrence-Dörner AM; Besir H; Wilmanns M; Jensen JK; Thiede B; Mills IG; Morth JP
    Biochem Biophys Res Commun; 2016 Jul; 476(2):102-7. PubMed ID: 27178209
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert.
    Kylarova S; Psenakova K; Herman P; Obsilova V; Obsil T
    Biochim Biophys Acta Gen Subj; 2018 Oct; 1862(10):2304-2313. PubMed ID: 30053538
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.
    O'Byrne SN; Scott JW; Pilotte JR; Santiago ADS; Langendorf CG; Oakhill JS; Eduful BJ; Couñago RM; Wells CI; Zuercher WJ; Willson TM; Drewry DH
    Molecules; 2020 Jan; 25(2):. PubMed ID: 31941153
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.
    De SK; Chen V; Stebbins JL; Chen LH; Cellitti JF; Machleidt T; Barile E; Riel-Mehan M; Dahl R; Yang L; Emdadi A; Murphy R; Pellecchia M
    Bioorg Med Chem; 2010 Jan; 18(2):590-6. PubMed ID: 20045647
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.
    Kukimoto-Niino M; Yoshikawa S; Takagi T; Ohsawa N; Tomabechi Y; Terada T; Shirouzu M; Suzuki A; Lee S; Yamauchi T; Okada-Iwabu M; Iwabu M; Kadowaki T; Minokoshi Y; Yokoyama S
    J Biol Chem; 2011 Jun; 286(25):22570-9. PubMed ID: 21504895
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitors: a novel approach in small molecule discovery.
    Devasahayam Arokia Balaya R; Chandrasekaran J; Kanekar S; Kumar Modi P; Dagamajalu S; Gopinathan K; Raju R; Prasad TSK
    J Biomol Struct Dyn; 2023; 41(24):15196-15206. PubMed ID: 37029757
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).
    Psenakova K; Petrvalska O; Kylarova S; Lentini Santo D; Kalabova D; Herman P; Obsilova V; Obsil T
    Biochim Biophys Acta Gen Subj; 2018 Jul; 1862(7):1612-1625. PubMed ID: 29649512
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.
    Zhang L; Zhao J; Zhang B; Lu T; Chen Y
    Eur J Med Chem; 2018 Apr; 150():809-816. PubMed ID: 29602036
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors.
    Rzasa RM; Kaller MR; Liu G; Magal E; Nguyen TT; Osslund TD; Powers D; Santora VJ; Viswanadhan VN; Wang HL; Xiong X; Zhong W; Norman MH
    Bioorg Med Chem; 2007 Oct; 15(20):6574-95. PubMed ID: 17697781
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.
    Subbannayya Y; Syed N; Barbhuiya MA; Raja R; Marimuthu A; Sahasrabuddhe N; Pinto SM; Manda SS; Renuse S; Manju HC; Zameer MA; Sharma J; Brait M; Srikumar K; Roa JC; Vijaya Kumar M; Kumar KV; Prasad TS; Ramaswamy G; Kumar RV; Pandey A; Gowda H; Chatterjee A
    Cancer Biol Ther; 2015; 16(2):336-45. PubMed ID: 25756516
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
    Price DJ; Drewry DH; Schaller LT; Thompson BD; Reid PR; Maloney PR; Liang X; Banker P; Buckholz RG; Selley PK; McDonald OB; Smith JL; Shearer TW; Cox RF; Williams SP; Reid RA; Tacconi S; Faggioni F; Piubelli C; Sartori I; Tessari M; Wang TY
    Bioorg Med Chem Lett; 2018 Jun; 28(10):1958-1963. PubMed ID: 29653895
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5).
    Patel HM; Sing B; Bhardwaj V; Palkar M; Shaikh MS; Rane R; Alwan WS; Gadad AK; Noolvi MN; Karpoormath R
    Eur J Med Chem; 2015 Mar; 93():599-613. PubMed ID: 25234355
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
    Shin D; Lee SC; Heo YS; Lee WY; Cho YS; Kim YE; Hyun YL; Cho JM; Lee YS; Ro S
    Bioorg Med Chem Lett; 2007 Oct; 17(20):5686-9. PubMed ID: 17764934
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
    Lentini Santo D; Petrvalska O; Obsilova V; Ottmann C; Obsil T
    ACS Chem Biol; 2020 Nov; 15(11):3060-3071. PubMed ID: 33146997
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors.
    Gomha SM; Abdulla MM; Abou-Seri SM
    Eur J Med Chem; 2015 Mar; 92():459-70. PubMed ID: 25594740
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
    Takaya D; Niwa H; Mikuni J; Nakamura K; Handa N; Tanaka A; Yokoyama S; Honma T
    J Mol Graph Model; 2020 Sep; 99():107599. PubMed ID: 32348940
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.