BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

411 related articles for article (PubMed ID: 29793408)

  • 1. Recent Development of Small Molecule Glutaminase Inhibitors.
    Song M; Kim SH; Im CY; Hwang HJ
    Curr Top Med Chem; 2018; 18(6):432-443. PubMed ID: 29793408
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
    Huang Q; Stalnecker C; Zhang C; McDermott LA; Iyer P; O'Neill J; Reimer S; Cerione RA; Katt WP
    J Biol Chem; 2018 Mar; 293(10):3535-3545. PubMed ID: 29317493
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase.
    Zimmermann SC; Duvall B; Tsukamoto T
    J Med Chem; 2019 Jan; 62(1):46-59. PubMed ID: 29969024
    [TBL] [Abstract][Full Text] [Related]  

  • 4. GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.
    McDermott L; Koes D; Mohammed S; Iyer P; Boby M; Balasubramanian V; Geedy M; Katt W; Cerione R
    Bioorg Med Chem Lett; 2019 Oct; 29(19):126632. PubMed ID: 31474484
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Glutaminase inhibitors: a patent review.
    Wu C; Chen L; Jin S; Li H
    Expert Opin Ther Pat; 2018 Nov; 28(11):823-835. PubMed ID: 30273516
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.
    Ramachandran S; Pan CQ; Zimmermann SC; Duvall B; Tsukamoto T; Low BC; Sivaraman J
    Oncotarget; 2016 Sep; 7(36):57943-57954. PubMed ID: 27462863
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.
    Matre P; Velez J; Jacamo R; Qi Y; Su X; Cai T; Chan SM; Lodi A; Sweeney SR; Ma H; Davis RE; Baran N; Haferlach T; Su X; Flores ER; Gonzalez D; Konoplev S; Samudio I; DiNardo C; Majeti R; Schimmer AD; Li W; Wang T; Tiziani S; Konopleva M
    Oncotarget; 2016 Nov; 7(48):79722-79735. PubMed ID: 27806325
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions.
    Xu X; Meng Y; Li L; Xu P; Wang J; Li Z; Bian J
    J Med Chem; 2019 Feb; 62(3):1096-1115. PubMed ID: 30148361
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
    Shukla K; Ferraris DV; Thomas AG; Stathis M; Duvall B; Delahanty G; Alt J; Rais R; Rojas C; Gao P; Xiang Y; Dang CV; Slusher BS; Tsukamoto T
    J Med Chem; 2012 Dec; 55(23):10551-63. PubMed ID: 23151085
    [TBL] [Abstract][Full Text] [Related]  

  • 10. New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography.
    Milano SK; Huang Q; Nguyen TT; Ramachandran S; Finke A; Kriksunov I; Schuller DJ; Szebenyi DM; Arenholz E; McDermott LA; Sukumar N; Cerione RA; Katt WP
    J Biol Chem; 2022 Feb; 298(2):101535. PubMed ID: 34954143
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice.
    Boysen G; Jamshidi-Parsian A; Davis MA; Siegel ER; Simecka CM; Kore RA; Dings RPM; Griffin RJ
    Int J Radiat Biol; 2019 Apr; 95(4):436-442. PubMed ID: 30557074
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.
    Finlay MRV; Anderton M; Bailey A; Boyd S; Brookfield J; Cairnduff C; Charles M; Cheasty A; Critchlow SE; Culshaw J; Ekwuru T; Hollingsworth I; Jones N; Leroux F; Littleson M; McCarron H; McKelvie J; Mooney L; Nissink JWM; Perkins D; Powell S; Quesada MJ; Raubo P; Sabin V; Smith J; Smith PD; Stark A; Ting A; Wang P; Wilson Z; Winter-Holt JJ; Wood JM; Wrigley GL; Yu G; Zhang P
    J Med Chem; 2019 Jul; 62(14):6540-6560. PubMed ID: 31199640
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.
    Katt WP; Lukey MJ; Cerione RA
    Future Med Chem; 2017 Jan; 9(2):223-243. PubMed ID: 28111979
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and evaluation of novel glutaminase inhibitors.
    McDermott LA; Iyer P; Vernetti L; Rimer S; Sun J; Boby M; Yang T; Fioravanti M; O'Neill J; Wang L; Drakes D; Katt W; Huang Q; Cerione R
    Bioorg Med Chem; 2016 Apr; 24(8):1819-39. PubMed ID: 26988803
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
    Duvall B; Zimmermann SC; Gao RD; Thomas AG; KalĨic F; Veeravalli V; Elgogary A; Rais R; Rojas C; Le A; Slusher BS; Tsukamoto T
    Bioorg Med Chem; 2020 Oct; 28(20):115698. PubMed ID: 33069080
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis.
    Tsai HW; Motz KM; Ding D; Lina I; Murphy MK; Benner D; Feeley M; Hooper J; Hillel AT
    Laryngoscope; 2020 Dec; 130(12):E773-E781. PubMed ID: 31904876
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
    Xiang Y; Stine ZE; Xia J; Lu Y; O'Connor RS; Altman BJ; Hsieh AL; Gouw AM; Thomas AG; Gao P; Sun L; Song L; Yan B; Slusher BS; Zhuo J; Ooi LL; Lee CG; Mancuso A; McCallion AS; Le A; Milone MC; Rayport S; Felsher DW; Dang CV
    J Clin Invest; 2015 Jun; 125(6):2293-306. PubMed ID: 25915584
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES).
    Robinson MM; McBryant SJ; Tsukamoto T; Rojas C; Ferraris DV; Hamilton SK; Hansen JC; Curthoys NP
    Biochem J; 2007 Sep; 406(3):407-14. PubMed ID: 17581113
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.
    Thomas AG; O'Driscoll CM; Bressler J; Kaufmann W; Rojas CJ; Slusher BS
    Biochem Biophys Res Commun; 2014 Jan; 443(1):32-6. PubMed ID: 24269238
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer.
    Singleton DC; Dechaume AL; Murray PM; Katt WP; Baguley BC; Leung EY
    BMC Cancer; 2020 May; 20(1):470. PubMed ID: 32450839
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.