BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 29798906)

  • 1. Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients.
    Sanai N; Li J; Boerner J; Stark K; Wu J; Kim S; Derogatis A; Mehta S; Dhruv HD; Heilbrun LK; Berens ME; LoRusso PM
    Clin Cancer Res; 2018 Aug; 24(16):3820-3828. PubMed ID: 29798906
    [No Abstract]   [Full Text] [Related]  

  • 2. Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach.
    Li J; Wu J; Bao X; Honea N; Xie Y; Kim S; Sparreboom A; Sanai N
    Clin Cancer Res; 2017 Dec; 23(24):7454-7466. PubMed ID: 28928160
    [No Abstract]   [Full Text] [Related]  

  • 3. An aqueous normal-phase chromatography coupled with tandem mass spectrometry method for determining unbound brain-to-plasma concentration ratio of AZD1775, a Wee1 kinase inhibitor, in patients with glioblastoma.
    Wu J; Sanai N; Bao X; LoRusso P; Li J
    J Chromatogr B Analyt Technol Biomed Life Sci; 2016 Aug; 1028():25-32. PubMed ID: 27318641
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort.
    Tien AC; Li J; Bao X; Derogatis A; Kim S; Mehta S; Sanai N
    Clin Cancer Res; 2019 Oct; 25(19):5777-5786. PubMed ID: 31285369
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.
    Do K; Wilsker D; Ji J; Zlott J; Freshwater T; Kinders RJ; Collins J; Chen AP; Doroshow JH; Kummar S
    J Clin Oncol; 2015 Oct; 33(30):3409-15. PubMed ID: 25964244
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma.
    Méndez E; Rodriguez CP; Kao MC; Raju S; Diab A; Harbison RA; Konnick EQ; Mugundu GM; Santana-Davila R; Martins R; Futran ND; Chow LQM
    Clin Cancer Res; 2018 Jun; 24(12):2740-2748. PubMed ID: 29535125
    [No Abstract]   [Full Text] [Related]  

  • 7. Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.
    Någård M; Ah-See ML; So K; Vermunt M; Thistlethwaite F; Labots M; Roxburgh P; Ravaud A; Campone M; Valkenburg-van Iersel L; Ottesen L; Li Y; Mugundu G
    Cancer Chemother Pharmacol; 2020 Jul; 86(1):97-108. PubMed ID: 32556602
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.
    Infante JR; Fecher LA; Falchook GS; Nallapareddy S; Gordon MS; Becerra C; DeMarini DJ; Cox DS; Xu Y; Morris SR; Peddareddigari VG; Le NT; Hart L; Bendell JC; Eckhardt G; Kurzrock R; Flaherty K; Burris HA; Messersmith WA
    Lancet Oncol; 2012 Aug; 13(8):773-81. PubMed ID: 22805291
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma.
    Mehta S; Fiorelli R; Bao X; Pennington-Krygier C; Derogatis A; Kim S; Yoo W; Li J; Sanai N
    Clin Cancer Res; 2022 Jan; 28(2):289-297. PubMed ID: 34702773
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.
    Butowski N; Colman H; De Groot JF; Omuro AM; Nayak L; Wen PY; Cloughesy TF; Marimuthu A; Haidar S; Perry A; Huse J; Phillips J; West BL; Nolop KB; Hsu HH; Ligon KL; Molinaro AM; Prados M
    Neuro Oncol; 2016 Apr; 18(4):557-64. PubMed ID: 26449250
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Strategic development of AZD1775, a Wee1 kinase inhibitor, for cancer therapy.
    Fu S; Wang Y; Keyomarsi K; Meric-Bernstam F; Meric-Bernstein F
    Expert Opin Investig Drugs; 2018 Sep; 27(9):741-751. PubMed ID: 30102076
    [TBL] [Abstract][Full Text] [Related]  

  • 12. AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy.
    Yin Y; Wang J; Yi J; Zhang K; Yin Z; Jin S; Zheng B
    Chin Med J (Engl); 2024 Jan; 137(2):222-231. PubMed ID: 38167245
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk
    Tanaka N; Patel AA; Tang L; Silver NL; Lindemann A; Takahashi H; Jaksik R; Rao X; Kalu NN; Chen TC; Wang J; Frederick MJ; Johnson F; Gleber-Netto FO; Fu S; Kimmel M; Wang J; Hittelman WN; Pickering CR; Myers JN; Osman AA
    Clin Cancer Res; 2017 Nov; 23(21):6541-6554. PubMed ID: 28790110
    [No Abstract]   [Full Text] [Related]  

  • 14. ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.
    de Gooijer MC; Buil LCM; Beijnen JH; van Tellingen O
    Invest New Drugs; 2018 Jun; 36(3):380-387. PubMed ID: 29147815
    [TBL] [Abstract][Full Text] [Related]  

  • 15. WEE1 inhibitor, AZD1775, overcomes trastuzumab resistance by targeting cancer stem-like properties in HER2-positive breast cancer.
    Sand A; Piacsek M; Donohoe DL; Duffin AT; Riddell GT; Sun C; Tang M; Rovin RA; Tjoe JA; Yin J
    Cancer Lett; 2020 Mar; 472():119-131. PubMed ID: 31866466
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint.
    Lin X; Chen D; Zhang C; Zhang X; Li Z; Dong B; Gao J; Shen L
    J Exp Clin Cancer Res; 2018 Jun; 37(1):129. PubMed ID: 29954437
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia.
    Garcia TB; Snedeker JC; Baturin D; Gardner L; Fosmire SP; Zhou C; Jordan CT; Venkataraman S; Vibhakar R; Porter CC
    Mol Cancer Ther; 2017 Oct; 16(10):2058-2068. PubMed ID: 28655785
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months.
    Leijen S; van Geel RM; Sonke GS; de Jong D; Rosenberg EH; Marchetti S; Pluim D; van Werkhoven E; Rose S; Lee MA; Freshwater T; Beijnen JH; Schellens JH
    J Clin Oncol; 2016 Dec; 34(36):4354-4361. PubMed ID: 27998224
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
    Wen PY; Touat M; Alexander BM; Mellinghoff IK; Ramkissoon S; McCluskey CS; Pelton K; Haidar S; Basu SS; Gaffey SC; Brown LE; Martinez-Ledesma JE; Wu S; Kim J; Wei W; Park MA; Huse JT; Kuhn JG; Rinne ML; Colman H; Agar NYR; Omuro AM; DeAngelis LM; Gilbert MR; de Groot JF; Cloughesy TF; Chi AS; Roberts TM; Zhao JJ; Lee EQ; Nayak L; Heath JR; Horky LL; Batchelor TT; Beroukhim R; Chang SM; Ligon AH; Dunn IF; Koul D; Young GS; Prados MD; Reardon DA; Yung WKA; Ligon KL
    J Clin Oncol; 2019 Mar; 37(9):741-750. PubMed ID: 30715997
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Preclinical evaluation of the combination of AZD1775 and irinotecan against selected pediatric solid tumors: A Pediatric Preclinical Testing Consortium report.
    Kolb EA; Houghton PJ; Kurmasheva RT; Mosse YP; Maris JM; Erickson SW; Guo Y; Teicher BA; Smith MA; Gorlick R
    Pediatr Blood Cancer; 2020 May; 67(5):e28098. PubMed ID: 31975571
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.