These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 29805075)

  • 1. Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy.
    Qin LH; Wang ZL; Xie X; Long YQ
    Bioorg Med Chem; 2018 Jul; 26(12):3559-3572. PubMed ID: 29805075
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2).
    Strunz AK; Zweemer AJ; Weiss C; Schepmann D; Junker A; Heitman LH; Koch M; Wünsch B
    Bioorg Med Chem; 2015 Jul; 23(14):4034-49. PubMed ID: 25766632
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold.
    Thum S; Kokornaczyk AK; Seki T; De Maria M; Ortiz Zacarias NV; de Vries H; Weiss C; Koch M; Schepmann D; Kitamura M; Tschammer N; Heitman LH; Junker A; Wünsch B
    Eur J Med Chem; 2017 Jul; 135():401-413. PubMed ID: 28463783
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.
    Yang L; Butora G; Jiao RX; Pasternak A; Zhou C; Parsons WH; Mills SG; Vicario PP; Ayala JM; Cascieri MA; MacCoss M
    J Med Chem; 2007 May; 50(11):2609-11. PubMed ID: 17461566
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of novel small molecule CCR2 antagonists: evaluation of 4-aminopiperidine derivatives.
    Vilums M; Zweemer AJ; Dekkers S; Askar Y; de Vries H; Saunders J; Stamos D; Brussee J; Heitman LH; IJzerman AP
    Bioorg Med Chem Lett; 2014 Dec; 24(23):5377-80. PubMed ID: 25453791
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists.
    Junker A; Kokornaczyk AK; Zweemer AJ; Frehland B; Schepmann D; Yamaguchi J; Itami K; Faust A; Hermann S; Wagner S; Schäfers M; Koch M; Weiss C; Heitman LH; Kopka K; Wünsch B
    Org Biomol Chem; 2015 Feb; 13(8):2407-22. PubMed ID: 25566983
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2.
    Buntinx M; Hermans B; Goossens J; Moechars D; Gilissen RA; Doyon J; Boeckx S; Coesemans E; Van Lommen G; Van Wauwe JP
    J Pharmacol Exp Ther; 2008 Oct; 327(1):1-9. PubMed ID: 18599682
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2.
    Xue CB; Wang A; Meloni D; Zhang K; Kong L; Feng H; Glenn J; Huang T; Zhang Y; Cao G; Anand R; Zheng C; Xia M; Han Q; Robinson DJ; Storace L; Shao L; Li M; Brodmerkel CM; Covington M; Scherle P; Diamond S; Yeleswaram S; Vaddi K; Newton R; Hollis G; Friedman S; Metcalf B
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7473-8. PubMed ID: 21036044
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
    Cherney RJ; Brogan JB; Mo R; Lo YC; Yang G; Miller PB; Scherle PA; Molino BF; Carter PH; Decicco CP
    Bioorg Med Chem Lett; 2009 Feb; 19(3):597-601. PubMed ID: 19131247
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.
    Brown GD; Shi Q; Delucca GV; Batt DG; Galella MA; Cvijic ME; Liu RQ; Qiu F; Zhao Q; Barrish JC; Carter PH
    Bioorg Med Chem Lett; 2016 Jan; 26(2):662-666. PubMed ID: 26631321
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.
    Hall SE; Mao A; Nicolaidou V; Finelli M; Wise EL; Nedjai B; Kanjanapangka J; Harirchian P; Chen D; Selchau V; Ribeiro S; Schyler S; Pease JE; Horuk R; Vaidehi N
    Mol Pharmacol; 2009 Jun; 75(6):1325-36. PubMed ID: 19297521
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tin-free radical cyclizations for the synthesis of 7-azaoxindoles, 7-azaindolines, tetrahydro[1,8]naphthyridines, and tetrahydro-5H-pyrido[2,3-b]azepin-8-ones.
    Bacqué E; El Qacemi M; Zard SZ
    Org Lett; 2004 Oct; 6(21):3671-4. PubMed ID: 15469320
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2.
    Zweemer AJ; Bunnik J; Veenhuizen M; Miraglia F; Lenselink EB; Vilums M; de Vries H; Gibert A; Thiele S; Rosenkilde MM; IJzerman AP; Heitman LH
    Mol Pharmacol; 2014 Oct; 86(4):358-68. PubMed ID: 25024169
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The synthesis and vasopressin (AVP) antagonist activity of a novel series of N-aroyl-2,4,5,6-tetrahydropyrazolo[3,4-d]thieno[3,2-b]azepines.
    Albright JD; Delos Santos EG; Dusza JP; Chan PS; Coupet J; Ru X; Mazandarani H
    Bioorg Med Chem Lett; 2000 Apr; 10(8):695-8. PubMed ID: 10782666
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Fingerprint directed scaffold hopping for identification of CCR2 antagonists.
    Nair PC; Sobhia ME
    J Chem Inf Model; 2008 Sep; 48(9):1891-902. PubMed ID: 18763838
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Progress in the discovery of CC chemokine receptor 2 antagonists, 2009 - 2012.
    Carter PH
    Expert Opin Ther Pat; 2013 May; 23(5):549-68. PubMed ID: 23428142
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists.
    Cherney RJ; Nelson DJ; Lo YC; Yang G; Scherle PA; Jezak H; Solomon KA; Carter PH; Decicco CP
    Bioorg Med Chem Lett; 2008 Sep; 18(18):5063-5. PubMed ID: 18722120
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.
    Shireman BT; Dvorak CA; Rudolph DA; Bonaventure P; Nepomuceno D; Dvorak L; Miller KL; Lovenberg TW; Carruthers NI
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2103-8. PubMed ID: 18282705
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The discovery of novel cyclohexylamide CCR2 antagonists.
    Lanter JC; Markotan TP; Zhang X; Subasinghe N; Kang FA; Hou C; Singer M; Opas E; McKenney S; Crysler C; Johnson D; Molloy CJ; Sui Z
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7496-501. PubMed ID: 22061641
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2).
    Carter PH; Brown GD; Friedrich SR; Cherney RJ; Tebben AJ; Lo YC; Yang G; Jezak H; Solomon KA; Scherle PA; Decicco CP
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5455-61. PubMed ID: 17720492
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.