180 related articles for article (PubMed ID: 2982373)
1. Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.
De Clercq E; Balzarini J; Bernaerts R; Herdewijn P; Verbruggen A
Biochem Biophys Res Commun; 1985 Jan; 126(1):397-403. PubMed ID: 2982373
[TBL] [Abstract][Full Text] [Related]
2. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Seno T
Mol Pharmacol; 1985 Dec; 28(6):581-7. PubMed ID: 3001499
[TBL] [Abstract][Full Text] [Related]
3. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Shimizu K; Seno T
Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
[TBL] [Abstract][Full Text] [Related]
4. Differential metabolism of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by equine herpesvirus type 1- and herpes simplex virus-infected cells.
Kit S; Ichimura H; De Clercq E
Antiviral Res; 1987 Aug; 8(1):41-51. PubMed ID: 2825591
[TBL] [Abstract][Full Text] [Related]
5. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
Balzarini J; De Clercq E; Baumgartner H; Bodenteich M; Griengl H
Mol Pharmacol; 1990 Mar; 37(3):395-401. PubMed ID: 2156153
[TBL] [Abstract][Full Text] [Related]
6. Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds.
Balzarini J; De Clercq E; Verbruggen A; Crumpacker C; Ayusawa D; Seno T
Anticancer Res; 1986; 6(5):1077-84. PubMed ID: 2432829
[TBL] [Abstract][Full Text] [Related]
7. Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Balzarini J; de Clercq E; Ayusawa D; Seno T
FEBS Lett; 1985 Jun; 185(1):95-100. PubMed ID: 2987041
[TBL] [Abstract][Full Text] [Related]
8. Metabolism of the carbocyclic analogue of (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells. Incorporation of C-IVDU into DNA.
De Clercq E; Bernaerts R; Balzarini J; Herdewijn P; Verbruggen A
J Biol Chem; 1985 Sep; 260(19):10621-8. PubMed ID: 2993282
[TBL] [Abstract][Full Text] [Related]
9. Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins.
Cheng YC; Dutschman G; De Clercq E; Jones AS; Rahim SG; Verhelst G; Walker RT
Mol Pharmacol; 1981 Jul; 20(1):230-3. PubMed ID: 6270535
[No Abstract] [Full Text] [Related]
10. Role of the incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine and its carbocyclic analogue into DNA of herpes simplex virus type 1-infected cells in the antiviral effects of these compounds.
Balzarini J; Bernaerts R; Verbruggen A; De Clercq E
Mol Pharmacol; 1990 Mar; 37(3):402-7. PubMed ID: 2156154
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Herdewijn P; De Clercq E; Balzarini J; Vanderhaeghe H
J Med Chem; 1985 May; 28(5):550-5. PubMed ID: 2985782
[TBL] [Abstract][Full Text] [Related]
12. Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells.
Descamps J; De Clercq E
J Biol Chem; 1981 Jun; 256(12):5973-6. PubMed ID: 6263899
[TBL] [Abstract][Full Text] [Related]
13. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Balzarini J; Bohman C; De Clercq E
J Biol Chem; 1993 Mar; 268(9):6332-7. PubMed ID: 8384209
[TBL] [Abstract][Full Text] [Related]
14. 5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies.
Spadari S; Ciarrocchi G; Focher F; Verri A; Maga G; Arcamone F; Iafrate E; Manzini S; Garbesi A; Tondelli L
Mol Pharmacol; 1995 Jun; 47(6):1231-8. PubMed ID: 7603465
[TBL] [Abstract][Full Text] [Related]
15. Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells.
Bubley G; Crumpacker C; De Clercq E; Schnipper L
Virology; 1983 Sep; 129(2):490-2. PubMed ID: 6312685
[TBL] [Abstract][Full Text] [Related]
16. Incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine into deoxyribonucleic acids of varicella-zoster virus (TK+ and TK- strains)-infected cells.
Yokota T; Konno K; Shigeta S; Verbruggen A; De Clercq E
Mol Pharmacol; 1987 May; 31(5):493-9. PubMed ID: 3033468
[TBL] [Abstract][Full Text] [Related]
17. Differential binding affinities of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine for herpes simplex virus-induced and human cellular deoxythymidine kinases.
Zou FC; Dutschman GE; De Clercq E; Cheng YC
Biochem Pharmacol; 1984 Jun; 33(11):1797-800. PubMed ID: 6329218
[TBL] [Abstract][Full Text] [Related]
18. Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
Degrève B; De Clercq E; Balzarini J
Gene Ther; 2000 Sep; 7(18):1543-52. PubMed ID: 11021592
[TBL] [Abstract][Full Text] [Related]
19. Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Wilber BA; Docherty JJ
J Gen Virol; 1994 Jul; 75 ( Pt 7)():1743-7. PubMed ID: 8021603
[TBL] [Abstract][Full Text] [Related]
20. Comparison of thymidine kinase activities indiced in cells productively infected with herpesvirus saimiri and herpes simplex virus.
Honess RW; O'Hare P; Young D
J Gen Virol; 1982 Feb; 58(Pt 2):237-49. PubMed ID: 6278057
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
