These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 29860311)

  • 1. PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.
    Bondar VV; Adamski CJ; Onur TS; Tan Q; Wang L; Diaz-Garcia J; Park J; Orr HT; Botas J; Zoghbi HY
    Hum Mol Genet; 2018 Aug; 27(16):2863-2873. PubMed ID: 29860311
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
    Lee WS; Lavery L; Rousseaux MWC; Rutledge EB; Jang Y; Wan YW; Wu SR; Kim W; Al-Ramahi I; Rath S; Adamski CJ; Bondar VV; Tewari A; Soleimani S; Mota S; Yalamanchili HK; Orr HT; Liu Z; Botas J; Zoghbi HY
    EMBO J; 2021 Apr; 40(7):e106106. PubMed ID: 33709453
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).
    Sánchez I; Balagué E; Matilla-Dueñas A
    Hum Mol Genet; 2016 Sep; 25(18):4021-4040. PubMed ID: 27466200
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
    Nitschke L; Coffin SL; Xhako E; El-Najjar DB; Orengo JP; Alcala E; Dai Y; Wan YW; Liu Z; Orr HT; Zoghbi HY
    JCI Insight; 2021 Feb; 6(3):. PubMed ID: 33554954
    [TBL] [Abstract][Full Text] [Related]  

  • 5. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
    Park J; Al-Ramahi I; Tan Q; Mollema N; Diaz-Garcia JR; Gallego-Flores T; Lu HC; Lagalwar S; Duvick L; Kang H; Lee Y; Jafar-Nejad P; Sayegh LS; Richman R; Liu X; Gao Y; Shaw CA; Arthur JSC; Orr HT; Westbrook TF; Botas J; Zoghbi HY
    Nature; 2013 Jun; 498(7454):325-331. PubMed ID: 23719381
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
    Ju H; Kokubu H; Todd TW; Kahle JJ; Kim S; Richman R; Chirala K; Orr HT; Zoghbi HY; Lim J
    J Neurosci; 2013 May; 33(22):9328-36. PubMed ID: 23719801
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.
    Pérez Ortiz JM; Mollema N; Toker N; Adamski CJ; O'Callaghan B; Duvick L; Friedrich J; Walters MA; Strasser J; Hawkinson JE; Zoghbi HY; Henzler C; Orr HT; Lagalwar S
    Neurobiol Dis; 2018 Aug; 116():93-105. PubMed ID: 29758256
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1.
    Lee WS; Al-Ramahi I; Jeong HH; Jang Y; Lin T; Adamski CJ; Lavery LA; Rath S; Richman R; Bondar VV; Alcala E; Revelli JP; Orr HT; Liu Z; Botas J; Zoghbi HY
    J Clin Invest; 2022 May; 132(9):. PubMed ID: 35499073
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
    Rousseaux MWC; Tschumperlin T; Lu HC; Lackey EP; Bondar VV; Wan YW; Tan Q; Adamski CJ; Friedrich J; Twaroski K; Chen W; Tolar J; Henzler C; Sharma A; Bajić A; Lin T; Duvick L; Liu Z; Sillitoe RV; Zoghbi HY; Orr HT
    Neuron; 2018 Mar; 97(6):1235-1243.e5. PubMed ID: 29526553
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
    Crespo-Barreto J; Fryer JD; Shaw CA; Orr HT; Zoghbi HY
    PLoS Genet; 2010 Jul; 6(7):e1001021. PubMed ID: 20628574
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Spinocerebellar Ataxia Type 1: Molecular Mechanisms of Neurodegeneration and Preclinical Studies.
    Pérez Ortiz JM; Orr HT
    Adv Exp Med Biol; 2018; 1049():135-145. PubMed ID: 29427101
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phosphorylation of ATXN1 at Ser776 in the cerebellum.
    Jorgensen ND; Andresen JM; Lagalwar S; Armstrong B; Stevens S; Byam CE; Duvick LA; Lai S; Jafar-Nejad P; Zoghbi HY; Clark HB; Orr HT
    J Neurochem; 2009 Jul; 110(2):675-86. PubMed ID: 19500214
    [TBL] [Abstract][Full Text] [Related]  

  • 13. SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.
    Orr HT
    Prog Neurobiol; 2012 Dec; 99(3):179-85. PubMed ID: 22531670
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles.
    Handler HP; Duvick L; Mitchell JS; Cvetanovic M; Reighard M; Soles A; Mather KB; Rainwater O; Serres S; Nichols-Meade T; Coffin SL; You Y; Ruis BL; O'Callaghan B; Henzler C; Zoghbi HY; Orr HT
    Neuron; 2023 Feb; 111(4):493-507.e6. PubMed ID: 36577403
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
    Ju H; Kokubu H; Lim J
    Mol Neurobiol; 2014 Dec; 50(3):866-874. PubMed ID: 24752589
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1.
    Shuvaev AN; Belozor OS; Mozhei OI; Shuvaev AN; Fritsler YV; Khilazheva ED; Mosyagina AI; Hirai H; Teschemacher AG; Kasparov S
    Cells; 2022 Jul; 11(14):. PubMed ID: 35883691
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.
    Suart CE; Perez AM; Al-Ramahi I; Maiuri T; Botas J; Truant R
    Hum Mol Genet; 2021 May; 30(8):706-715. PubMed ID: 33772540
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Focused cerebellar laser light induced hyperthermia improves symptoms and pathology of polyglutamine disease SCA1 in a mouse model.
    Hearst SM; Shao Q; Lopez M; Raucher D; Vig PJ
    Cerebellum; 2014 Oct; 13(5):596-606. PubMed ID: 24930030
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.
    Sánchez I; Piñol P; Corral-Juan M; Pandolfo M; Matilla-Dueñas A
    Hum Mol Genet; 2013 Sep; 22(17):3425-37. PubMed ID: 23630944
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
    Gehrking KM; Andresen JM; Duvick L; Lough J; Zoghbi HY; Orr HT
    Hum Mol Genet; 2011 Jun; 20(11):2204-12. PubMed ID: 21427130
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.