These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

115 related articles for article (PubMed ID: 29863866)

  • 1. A Surprising Recipe for Designing Biased Ligands.
    Topiol S
    J Med Chem; 2019 Jan; 62(1):141-143. PubMed ID: 29863866
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
    Wilczynski A; Wang XS; Joseph CG; Xiang Z; Bauzo RM; Scott JW; Sorensen NB; Shaw AM; Millard WJ; Richards NG; Haskell-Luevano C
    J Med Chem; 2004 Apr; 47(9):2194-207. PubMed ID: 15084118
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.
    McCorvy JD; Butler KV; Kelly B; Rechsteiner K; Karpiak J; Betz RM; Kormos BL; Shoichet BK; Dror RO; Jin J; Roth BL
    Nat Chem Biol; 2018 Feb; 14(2):126-134. PubMed ID: 29227473
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.
    Lensing CJ; Freeman KT; Schnell SM; Speth RC; Zarth AT; Haskell-Luevano C
    J Med Chem; 2019 Jan; 62(1):144-158. PubMed ID: 29669202
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enhanced targeting with heterobivalent ligands.
    Xu L; Vagner J; Josan J; Lynch RM; Morse DL; Baggett B; Han H; Mash EA; Hruby VJ; Gillies RJ
    Mol Cancer Ther; 2009 Aug; 8(8):2356-65. PubMed ID: 19671749
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics.
    Xiao K; Sun J
    Cell Signal; 2018 Jan; 41():56-64. PubMed ID: 28939107
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Determination of the melanocortin-4 receptor structure identifies Ca
    Yu J; Gimenez LE; Hernandez CC; Wu Y; Wein AH; Han GW; McClary K; Mittal SR; Burdsall K; Stauch B; Wu L; Stevens SN; Peisley A; Williams SY; Chen V; Millhauser GL; Zhao S; Cone RD; Stevens RC
    Science; 2020 Apr; 368(6489):428-433. PubMed ID: 32327598
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors.
    Nivedha AK; Tautermann CS; Bhattacharya S; Lee S; Casarosa P; Kollak I; Kiechle T; Vaidehi N
    Mol Pharmacol; 2018 Apr; 93(4):288-296. PubMed ID: 29367258
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Understanding the GPCR biased signaling through G protein and arrestin complex structures.
    Zhou XE; Melcher K; Xu HE
    Curr Opin Struct Biol; 2017 Aug; 45():150-159. PubMed ID: 28558341
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Beta-arrestin-biased ligands at seven-transmembrane receptors.
    Violin JD; Lefkowitz RJ
    Trends Pharmacol Sci; 2007 Aug; 28(8):416-22. PubMed ID: 17644195
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
    Tan L; Yan W; McCorvy JD; Cheng J
    J Med Chem; 2018 Nov; 61(22):9841-9878. PubMed ID: 29939744
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity.
    Szewczyk JR; Laudeman CP; Sammond DM; Villeneuve M; Minick DJ; Grizzle MK; Daniels AJ; Andrews JL; Ignar DM
    Bioorg Med Chem; 2010 Mar; 18(5):1822-33. PubMed ID: 20172734
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Emergent biological properties of arrestin pathway-selective biased agonism.
    Appleton KM; Luttrell LM
    J Recept Signal Transduct Res; 2013 Jun; 33(3):153-61. PubMed ID: 23448506
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The structural basis of arrestin-mediated regulation of G-protein-coupled receptors.
    Gurevich VV; Gurevich EV
    Pharmacol Ther; 2006 Jun; 110(3):465-502. PubMed ID: 16460808
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.
    Yang Z; Tao YX
    Biochim Biophys Acta; 2016 Sep; 1862(9):1485-94. PubMed ID: 27208795
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Biased ligands at G-protein-coupled receptors: promise and progress.
    Violin JD; Crombie AL; Soergel DG; Lark MW
    Trends Pharmacol Sci; 2014 Jul; 35(7):308-16. PubMed ID: 24878326
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Emerging structural insights into biased GPCR signaling.
    Shukla AK; Singh G; Ghosh E
    Trends Biochem Sci; 2014 Dec; 39(12):594-602. PubMed ID: 25458114
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Agonist-dependent internalization of the human melanocortin-4 receptors in human embryonic kidney 293 cells.
    Gao Z; Lei D; Welch J; Le K; Lin J; Leng S; Duhl D
    J Pharmacol Exp Ther; 2003 Dec; 307(3):870-7. PubMed ID: 14534363
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity.
    Nargund RP; Strack AM; Fong TM
    J Med Chem; 2006 Jul; 49(14):4035-43. PubMed ID: 16821763
    [No Abstract]   [Full Text] [Related]  

  • 20. Computer-aided identification of ligands for GPCR anti-obesity targets.
    Min KH; Yoo J; Park HJ
    Curr Top Med Chem; 2009; 9(6):539-53. PubMed ID: 19689364
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.