BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 29874096)

  • 1. Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening.
    Koyama R; Fukuda Y; Kamada Y; Nakagawa H; Witmer D; Ambrus-Aikelin G; Sang BC; Nakayama M; Iwata H
    Assay Drug Dev Technol; 2018; 16(4):194-204. PubMed ID: 29874096
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists.
    Ma X; Sun N; Li X; Fu W
    Eur J Med Chem; 2021 Oct; 222():113585. PubMed ID: 34118722
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases.
    Sun N; Ma X; Zhou K; Zhu C; Cao Z; Wang Y; Xu J; Fu W
    Eur J Med Chem; 2020 Feb; 187():111984. PubMed ID: 31881455
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
    Yukawa T; Nara Y; Kono M; Sato A; Oda T; Takagi T; Sato T; Banno Y; Taya N; Imada T; Shiokawa Z; Negoro N; Kawamoto T; Koyama R; Uchiyama N; Skene R; Hoffman I; Chen CH; Sang B; Snell G; Katsuyama R; Yamamoto S; Shirai J
    J Med Chem; 2019 Feb; 62(3):1167-1179. PubMed ID: 30652849
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular Mechanism of Action of RORγt Agonists and Inverse Agonists: Insights from Molecular Dynamics Simulation.
    Sun N; Yuan C; Ma X; Wang Y; Gu X; Fu W
    Molecules; 2018 Dec; 23(12):. PubMed ID: 30513894
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Agonist Lock Touched and Untouched Retinoic Acid Receptor-Related Orphan Receptor-γt (RORγt) Inverse Agonists: Classification Based on the Molecular Mechanisms of Action.
    Sun N; Xie Q; Dang Y; Wang Y
    J Med Chem; 2021 Aug; 64(15):10519-10536. PubMed ID: 34264059
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists.
    Lu L; Chen S; Yu M; Zhou R; Guo S; Chen JA; Wang H; Chen S; Luo C; Xie Q; Wang Y
    Eur J Med Chem; 2023 Aug; 256():115424. PubMed ID: 37167779
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.
    Kallen J; Izaac A; Be C; Arista L; Orain D; Kaupmann K; Guntermann C; Hoegenauer K; Hintermann S
    ChemMedChem; 2017 Jul; 12(13):1014-1021. PubMed ID: 28590087
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of novel quinazolinedione derivatives as RORγt inverse agonist.
    Fukase Y; Sato A; Tomata Y; Ochida A; Kono M; Yonemori K; Koga K; Okui T; Yamasaki M; Fujitani Y; Nakagawa H; Koyama R; Nakayama M; Skene R; Sang BC; Hoffman I; Shirai J; Yamamoto S
    Bioorg Med Chem; 2018 Feb; 26(3):721-736. PubMed ID: 29342416
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of biaryls as RORγ inverse agonists by using structure-based design.
    Enyedy IJ; Powell NA; Caravella J; van Vloten K; Chao J; Banerjee D; Marcotte D; Silvian L; McKenzie A; Hong VS; Fontenot JD
    Bioorg Med Chem Lett; 2016 May; 26(10):2459-2463. PubMed ID: 27080181
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of Interleukin-23-Mediated Inflammation with a Novel Small Molecule Inverse Agonist of ROR
    Gauld SB; Jacquet S; Gauvin D; Wallace C; Wang Y; McCarthy R; Goess C; Leys L; Huang S; Su Z; Edelmayer R; Wetter J; Salte K; McGaraughty SP; Argiriadi MA; Honore P; Luccarini JM; Bressac D; Desino K; Breinlinger E; Cusack K; Potin D; Kort ME; Masson PJ
    J Pharmacol Exp Ther; 2019 Oct; 371(1):208-218. PubMed ID: 31375639
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.
    Li X; Anderson M; Collin D; Muegge I; Wan J; Brennan D; Kugler S; Terenzio D; Kennedy C; Lin S; Labadia ME; Cook B; Hughes R; Farrow NA
    J Biol Chem; 2017 Jul; 292(28):11618-11630. PubMed ID: 28546429
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-Based Design and Synthesis of Fluorene Derivatives as Novel RORγt Inverse Agonists.
    Gabr MT; Abdel-Raziq MS
    Chem Biodivers; 2018 Sep; 15(9):e1800244. PubMed ID: 29935095
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 6-Substituted quinolines as RORγt inverse agonists.
    Barbay JK; Cummings MD; Abad M; Castro G; Kreutter KD; Kummer DA; Maharoof U; Milligan C; Nishimura R; Pierce J; Schalk-Hihi C; Spurlino J; Tanis VM; Urbanski M; Venkatesan H; Wang A; Woods C; Wolin R; Xue X; Edwards JP; Fourie AM; Leonard K
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5277-5283. PubMed ID: 29079472
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
    Gege C; Albers M; Kinzel O; Kleymann G; Schlüter T; Steeneck C; Hoffmann T; Xue X; Cummings MD; Spurlino J; Milligan C; Fourie AM; Edwards JP; Leonard K; Coe K; Scott B; Pippel D; Goldberg SD
    Bioorg Med Chem Lett; 2020 Jun; 30(12):127205. PubMed ID: 32336498
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity.
    Pastwińska J; Karaś K; Sałkowska A; Karwaciak I; Chałaśkiewicz K; Wojtczak BA; Bachorz RA; Ratajewski M
    Int J Mol Sci; 2022 Feb; 23(3):. PubMed ID: 35163824
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of N-indanyl benzamides as potent RORγt inverse agonists.
    Tian J; Sun N; Yu M; Gu X; Xie Q; Shao L; Liu J; Liu L; Wang Y
    Eur J Med Chem; 2019 Apr; 167():37-48. PubMed ID: 30743096
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular dynamics simulations on RORγt: insights into its functional agonism and inverse agonism.
    Yuan CM; Chen HH; Sun NN; Ma XJ; Xu J; Fu W
    Acta Pharmacol Sin; 2019 Nov; 40(11):1480-1489. PubMed ID: 31316175
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.
    Gege C; Schlüter T; Hoffmann T
    Bioorg Med Chem Lett; 2014 Nov; 24(22):5265-7. PubMed ID: 25305688
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt.
    Leijten-van de Gevel IA; Brunsveld L
    J Biol Chem; 2020 Jul; 295(27):9183-9191. PubMed ID: 32439807
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.