BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

192 related articles for article (PubMed ID: 29877701)

  • 1. α-Helix or β-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
    Oddo A; Mortensen S; Thøgersen H; De Maria L; Hennen S; McGuire JN; Kofoed J; Linderoth L; Reedtz-Runge S
    Biochemistry; 2018 Jul; 57(28):4148-4154. PubMed ID: 29877701
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
    Deganutti G; Liang YL; Zhang X; Khoshouei M; Clydesdale L; Belousoff MJ; Venugopal H; Truong TT; Glukhova A; Keller AN; Gregory KJ; Leach K; Christopoulos A; Danev R; Reynolds CA; Zhao P; Sexton PM; Wootten D
    Nat Commun; 2022 Jan; 13(1):92. PubMed ID: 35013280
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).
    Yang D; de Graaf C; Yang L; Song G; Dai A; Cai X; Feng Y; Reedtz-Runge S; Hanson MA; Yang H; Jiang H; Stevens RC; Wang MW
    J Biol Chem; 2016 Jun; 291(25):12991-3004. PubMed ID: 27059958
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
    Swedberg JE; Schroeder CI; Mitchell JM; Fairlie DP; Edmonds DJ; Griffith DA; Ruggeri RB; Derksen DR; Loria PM; Price DA; Liras S; Craik DJ
    J Biol Chem; 2016 Jul; 291(30):15778-87. PubMed ID: 27226591
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics.
    Gómez Santiago C; Paci E; Donnelly D
    Biochem Biophys Res Commun; 2018 Mar; 498(2):359-365. PubMed ID: 29397068
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.
    Plisson F; Hill TA; Mitchell JM; Hoang HN; de Araujo AD; Xu W; Cotterell A; Edmonds DJ; Stanton RV; Derksen DR; Loria PM; Griffith DA; Price DA; Liras S; Fairlie DP
    Eur J Med Chem; 2017 Feb; 127():703-714. PubMed ID: 27823886
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.
    Runge S; Thøgersen H; Madsen K; Lau J; Rudolph R
    J Biol Chem; 2008 Apr; 283(17):11340-7. PubMed ID: 18287102
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Investigation of ECD conformational transition mechanism of GLP-1R by molecular dynamics simulations and Markov state model.
    Zhang J; Bai Q; Pérez-Sánchez H; Shang S; An X; Yao X
    Phys Chem Chem Phys; 2019 Apr; 21(16):8470-8481. PubMed ID: 30957116
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.
    Underwood CR; Garibay P; Knudsen LB; Hastrup S; Peters GH; Rudolph R; Reedtz-Runge S
    J Biol Chem; 2010 Jan; 285(1):723-30. PubMed ID: 19861722
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R).
    Koole C; Reynolds CA; Mobarec JC; Hick C; Sexton PM; Sakmar TP
    J Biol Chem; 2017 Apr; 292(17):7131-7144. PubMed ID: 28283573
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Exendin-4 Derivatives with an Albumin-Binding Moiety Show Decreased Renal Retention and Improved GLP-1 Receptor Targeting.
    Kaeppeli SAM; Jodal A; Gotthardt M; Schibli R; Béhé M
    Mol Pharm; 2019 Sep; 16(9):3760-3769. PubMed ID: 31393738
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking.
    Lucey M; Ashik T; Marzook A; Wang Y; Goulding J; Oishi A; Broichhagen J; Hodson DJ; Minnion J; Elani Y; Jockers R; Briddon SJ; Bloom SR; Tomas A; Jones B
    Mol Pharmacol; 2021 Oct; 100(4):319-334. PubMed ID: 34315812
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.
    Coopman K; Wallis R; Robb G; Brown AJ; Wilkinson GF; Timms D; Willars GB
    Mol Endocrinol; 2011 Oct; 25(10):1804-18. PubMed ID: 21868452
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1.
    López de Maturana R; Willshaw A; Kuntzsch A; Rudolph R; Donnelly D
    J Biol Chem; 2003 Mar; 278(12):10195-200. PubMed ID: 12524435
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.
    Runge S; Schimmer S; Oschmann J; Schiødt CB; Knudsen SM; Jeppesen CB; Madsen K; Lau J; Thøgersen H; Rudolph R
    Biochemistry; 2007 May; 46(19):5830-40. PubMed ID: 17444618
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists.
    Evers A; Haack T; Lorenz M; Bossart M; Elvert R; Henkel B; Stengelin S; Kurz M; Glien M; Dudda A; Lorenz K; Kadereit D; Wagner M
    J Med Chem; 2017 May; 60(10):4293-4303. PubMed ID: 28448133
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Exendin-4 from Heloderma suspectum venom: From discovery to its latest application as type II diabetes combatant.
    Yap MKK; Misuan N
    Basic Clin Pharmacol Toxicol; 2019 May; 124(5):513-527. PubMed ID: 30417596
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses.
    Lee CH; Jeon SJ; Cho KS; Moon E; Sapkota A; Jun HS; Ryu JH; Choi JW
    Mol Neurobiol; 2018 Apr; 55(4):3007-3020. PubMed ID: 28456941
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel Site-Specific Fatty Chain-Modified GLP-1 Receptor Agonist with Potent Antidiabetic Effects.
    Zhong X; Chen Z; Chen Q; Zhao W; Chen Z
    Molecules; 2019 Feb; 24(4):. PubMed ID: 30795583
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural and functional diversity among agonist-bound states of the GLP-1 receptor.
    Cary BP; Deganutti G; Zhao P; Truong TT; Piper SJ; Liu X; Belousoff MJ; Danev R; Sexton PM; Wootten D; Gellman SH
    Nat Chem Biol; 2022 Mar; 18(3):256-263. PubMed ID: 34937906
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.