BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

223 related articles for article (PubMed ID: 29880605)

  • 1. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.
    Wu D; Wang W; Chen W; Lian F; Lang L; Huang Y; Xu Y; Zhang N; Chen Y; Liu M; Nussinov R; Cheng F; Lu W; Huang J
    Haematologica; 2018 Sep; 103(9):1472-1483. PubMed ID: 29880605
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia.
    Zhou J; Yiying Quah J; Ng Y; Chooi JY; Hui-Min Toh S; Lin B; Zea Tan T; Hosoi H; Osato M; Seet Q; Ooi LAG; Lindmark B; McHale M; Chng WJ
    Haematologica; 2020 Sep; 105(9):2286-2297. PubMed ID: 33054053
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
    Sykes DB; Kfoury YS; Mercier FE; Wawer MJ; Law JM; Haynes MK; Lewis TA; Schajnovitz A; Jain E; Lee D; Meyer H; Pierce KA; Tolliday NJ; Waller A; Ferrara SJ; Eheim AL; Stoeckigt D; Maxcy KL; Cobert JM; Bachand J; Szekely BA; Mukherjee S; Sklar LA; Kotz JD; Clish CB; Sadreyev RI; Clemons PA; Janzer A; Schreiber SL; Scadden DT
    Cell; 2016 Sep; 167(1):171-186.e15. PubMed ID: 27641501
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
    Christian S; Merz C; Evans L; Gradl S; Seidel H; Friberg A; Eheim A; Lejeune P; Brzezinka K; Zimmermann K; Ferrara S; Meyer H; Lesche R; Stoeckigt D; Bauser M; Haegebarth A; Sykes DB; Scadden DT; Losman JA; Janzer A
    Leukemia; 2019 Oct; 33(10):2403-2415. PubMed ID: 30940908
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia.
    Sykes DB
    Expert Opin Ther Targets; 2018 Nov; 22(11):893-898. PubMed ID: 30318938
    [No Abstract]   [Full Text] [Related]  

  • 6. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-
    Sainas S; Giorgis M; Circosta P; Gaidano V; Bonanni D; Pippione AC; Bagnati R; Passoni A; Qiu Y; Cojocaru CF; Canepa B; Bona A; Rolando B; Mishina M; Ramondetti C; Buccinnà B; Piccinini M; Houshmand M; Cignetti A; Giraudo E; Al-Karadaghi S; Boschi D; Saglio G; Lolli ML
    J Med Chem; 2021 May; 64(9):5404-5428. PubMed ID: 33844533
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
    DeRatt LG; Christine Pietsch E; Tanner A; Shaffer P; Jacoby E; Wang W; Kazmi F; Zhang X; Attar RM; Edwards JP; Kuduk SD
    Bioorg Med Chem Lett; 2020 Nov; 30(22):127589. PubMed ID: 33007394
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mysteries of partial dihydroorotate dehydrogenase inhibition and leukemia terminal differentiation.
    Saunthararajah Y
    Haematologica; 2020 Sep; 105(9):2191-2193. PubMed ID: 33054042
    [No Abstract]   [Full Text] [Related]  

  • 9. Inhibition of mitochondrial complex III induces differentiation in acute myeloid leukemia.
    Zhang Y; Luo T; Ding X; Chang Y; Liu C; Zhang Y; Hao S; Yin Q; Jiang B
    Biochem Biophys Res Commun; 2021 Apr; 547():162-168. PubMed ID: 33610916
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity.
    Hu S; Ueda M; Stetson L; Ignatz-Hoover J; Moreton S; Chakrabarti A; Xia Z; Karan G; de Lima M; Agrawal MK; Wald DN
    Mol Cancer Ther; 2016 Jul; 15(7):1485-1494. PubMed ID: 27196775
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bifunctional Naphtho[2,3-
    Zuo Z; Liu X; Qian X; Zeng T; Sang N; Liu H; Zhou Y; Tao L; Zhou X; Su N; Yu Y; Chen Q; Luo Y; Zhao Y
    J Med Chem; 2020 Jul; 63(14):7633-7652. PubMed ID: 32496056
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.
    Wang X; Gao M; Zhang J; Ma Y; Qu W; Liang J; Wu H; Wen H
    Redox Biol; 2019 Jun; 24():101153. PubMed ID: 30909158
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells.
    Baumann P; Mandl-Weber S; Völkl A; Adam C; Bumeder I; Oduncu F; Schmidmaier R
    Mol Cancer Ther; 2009 Feb; 8(2):366-75. PubMed ID: 19174558
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents.
    Vyas VK; Variya B; Ghate MD
    Eur J Med Chem; 2014 Jul; 82():385-93. PubMed ID: 24929289
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia.
    Demajo S; Uribesalgo I; Gutiérrez A; Ballaré C; Capdevila S; Roth M; Zuber J; Martín-Caballero J; Di Croce L
    Oncogene; 2014 Nov; 33(48):5501-10. PubMed ID: 24292673
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Isobavachalcone isolated from
    Li Y; Qin X; Li P; Zhang H; Lin T; Miao Z; Ma S
    Drug Des Devel Ther; 2019; 13():1449-1460. PubMed ID: 31118579
    [No Abstract]   [Full Text] [Related]  

  • 17. Pivotal role of dihydroorotate dehydrogenase as a therapeutic target in adult T-cell leukemia.
    Ishikawa C; Mori N
    Eur J Haematol; 2024 Jul; 113(1):99-109. PubMed ID: 38558052
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.
    Sainas S; Pippione AC; Lupino E; Giorgis M; Circosta P; Gaidano V; Goyal P; Bonanni D; Rolando B; Cignetti A; Ducime A; Andersson M; Järvå M; Friemann R; Piccinini M; Ramondetti C; Buccinnà B; Al-Karadaghi S; Boschi D; Saglio G; Lolli ML
    J Med Chem; 2018 Jul; 61(14):6034-6055. PubMed ID: 29939742
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth.
    Kawatani M; Aono H; Shimizu T; Ohkura S; Hiranuma S; Muroi M; Ogawa N; Ohishi T; Ohba SI; Kawada M; Yamazaki K; Dan S; Osada H
    ACS Chem Biol; 2021 Nov; 16(11):2570-2580. PubMed ID: 34730931
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in
    Jiang X; Mak PY; Mu H; Tao W; Mak DH; Kornblau S; Zhang Q; Ruvolo P; Burks JK; Zhang W; McQueen T; Pan R; Zhou H; Konopleva M; Cortes J; Liu Q; Andreeff M; Carter BZ
    Clin Cancer Res; 2018 May; 24(10):2417-2429. PubMed ID: 29463558
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 12.