231 related articles for article (PubMed ID: 29886325)
1. Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR).
Francesconi V; Giovannini L; Santucci M; Cichero E; Costi MP; Naesens L; Giordanetto F; Tonelli M
Eur J Med Chem; 2018 Jul; 155():229-243. PubMed ID: 29886325
[TBL] [Abstract][Full Text] [Related]
2. Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Tonelli M; Naesens L; Gazzarrini S; Santucci M; Cichero E; Tasso B; Moroni A; Costi MP; Loddo R
Eur J Med Chem; 2017 Jul; 135():467-478. PubMed ID: 28477572
[TBL] [Abstract][Full Text] [Related]
3. Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.
Ng HL; Chen S; Chew EH; Chui WK
Eur J Med Chem; 2016 Jun; 115():63-74. PubMed ID: 26994844
[TBL] [Abstract][Full Text] [Related]
4. Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors.
Göktaş F; Özbil M; Cesur N; Vanderlinden E; Naesens L; Cesur Z
Arch Pharm (Weinheim); 2019 Nov; 352(11):e1900028. PubMed ID: 31531897
[TBL] [Abstract][Full Text] [Related]
5. Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives.
Göktaş F; Vanderlinden E; Naesens L; Cesur N; Cesur Z
Bioorg Med Chem; 2012 Dec; 20(24):7155-9. PubMed ID: 23117173
[TBL] [Abstract][Full Text] [Related]
6. Antifolate and antiproliferative activity of 6,8,10-triazaspiro[4.5]deca-6,8-dienes and 1,3,5-triazaspiro[5.5]undeca-1,3-dienes.
Ma X; Chui WK
Bioorg Med Chem; 2010 Jan; 18(2):737-43. PubMed ID: 20036565
[TBL] [Abstract][Full Text] [Related]
7. Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.
Srinivasan B; Tonddast-Navaei S; Skolnick J
Eur J Med Chem; 2015 Oct; 103():600-14. PubMed ID: 26414808
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro[4.5]decan-3-one derivatives.
Apaydın ÇB; Cesur N; Stevaert A; Naesens L; Cesur Z
Arch Pharm (Weinheim); 2019 Jun; 352(6):e1800330. PubMed ID: 31073993
[TBL] [Abstract][Full Text] [Related]
9. Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
Yuthavong Y; Vilaivan T; Chareonsethakul N; Kamchonwongpaisan S; Sirawaraporn W; Quarrell R; Lowe G
J Med Chem; 2000 Jul; 43(14):2738-44. PubMed ID: 10893311
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors.
Zhou X; Lin K; Ma X; Chui WK; Zhou W
Eur J Med Chem; 2017 Jan; 125():1279-1288. PubMed ID: 27886545
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis and anti-influenza virus activity of furan-substituted spirothiazolidinones.
Apaydın ÇB; Tansuyu M; Cesur Z; Naesens L; Göktaş F
Bioorg Chem; 2021 Jul; 112():104958. PubMed ID: 33979734
[TBL] [Abstract][Full Text] [Related]
12. 3D-QSAR Study on dihydro-1,3,5-triazines and their spiro derivatives as DHFR inhibitors by comparative molecular field analysis (CoMFA).
Ma X; Xiang G; Yap CW; Chui WK
Bioorg Med Chem Lett; 2012 May; 22(9):3194-7. PubMed ID: 22483391
[TBL] [Abstract][Full Text] [Related]
13. 1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity.
Yang X; Wedajo W; Yamada Y; Dahlroth SL; Neo JJ; Dick T; Chui WK
Eur J Med Chem; 2018 Jan; 144():262-276. PubMed ID: 29274493
[TBL] [Abstract][Full Text] [Related]
14. In silico ADMET study, docking, synthesis and antimalarial evaluation of thiazole-1,3,5-triazine derivatives as Pf-DHFR inhibitor.
Sahu S; Ghosh SK; Gahtori P; Pratap Singh U; Bhattacharyya DR; Bhat HR
Pharmacol Rep; 2019 Oct; 71(5):762-767. PubMed ID: 31351317
[TBL] [Abstract][Full Text] [Related]
15. In vitro biological evaluation of biguanides and dihydrotriazines against Brugia malayi and folate reversal studies.
Bag S; Tawari NR; Sharma R; Goswami K; Reddy MV; Degani MS
Acta Trop; 2010 Jan; 113(1):48-51. PubMed ID: 19769933
[TBL] [Abstract][Full Text] [Related]
16. Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase.
Bibi M; Qureshi NA; Sadiq A; Farooq U; Hassan A; Shaheen N; Asghar I; Umer D; Ullah A; Khan FA; Salman M; Bibi A; Rashid U
Eur J Med Chem; 2021 Jan; 210():112986. PubMed ID: 33187806
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A
J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
Bag S; Tawari NR; Queener SF; Degani MS
J Enzyme Inhib Med Chem; 2010 Jun; 25(3):331-9. PubMed ID: 19874136
[TBL] [Abstract][Full Text] [Related]
19. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
[TBL] [Abstract][Full Text] [Related]
20. Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates.
Ma X; Woon RS; Ho PC; Chui WK
Chem Biol Drug Des; 2009 Sep; 74(3):322-6. PubMed ID: 19703036
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]