194 related articles for article (PubMed ID: 29899115)
1. Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond.
Ong SC; Belgi A; van Lierop B; Delaine C; Andrikopoulos S; MacRaild CA; Norton RS; Haworth NL; Robinson AJ; Forbes BE
J Biol Chem; 2018 Jul; 293(30):11928-11943. PubMed ID: 29899115
[TBL] [Abstract][Full Text] [Related]
2. Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.
van Lierop B; Ong SC; Belgi A; Delaine C; Andrikopoulos S; Haworth NL; Menting JG; Lawrence MC; Robinson AJ; Forbes BE
Sci Rep; 2017 Dec; 7(1):17239. PubMed ID: 29222417
[TBL] [Abstract][Full Text] [Related]
3. Hierarchical protein "un-design": insulin's intrachain disulfide bridge tethers a recognition alpha-helix.
Weiss MA; Hua QX; Jia W; Chu YC; Wang RY; Katsoyannis PG
Biochemistry; 2000 Dec; 39(50):15429-40. PubMed ID: 11112528
[TBL] [Abstract][Full Text] [Related]
4. Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond.
Ong SC; Belgi A; Merriman AL; Delaine CA; van Lierop B; Andrikopoulos S; Robinson AJ; Forbes BE
Front Endocrinol (Lausanne); 2022; 13():907864. PubMed ID: 35832429
[TBL] [Abstract][Full Text] [Related]
5. Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
Glidden MD; Yang Y; Smith NA; Phillips NB; Carr K; Wickramasinghe NP; Ismail-Beigi F; Lawrence MC; Smith BJ; Weiss MA
J Biol Chem; 2018 Jan; 293(1):69-88. PubMed ID: 29114034
[TBL] [Abstract][Full Text] [Related]
6. Semisynthesis of A6-A11 lactam insulin.
Xu R; Jap E; Gubbins B; Hagemeyer CE; Karas JA
J Pept Sci; 2024 Feb; 30(2):e3542. PubMed ID: 37697741
[TBL] [Abstract][Full Text] [Related]
7. Insulin analog with additional disulfide bond has increased stability and preserved activity.
Vinther TN; Norrman M; Ribel U; Huus K; Schlein M; Steensgaard DB; Pedersen TÅ; Pettersson I; Ludvigsen S; Kjeldsen T; Jensen KJ; Hubálek F
Protein Sci; 2013 Mar; 22(3):296-305. PubMed ID: 23281053
[TBL] [Abstract][Full Text] [Related]
8. Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues.
Jirácek J; Záková L; Antolíková E; Watson CJ; Turkenburg JP; Dodson GG; Brzozowski AM
Proc Natl Acad Sci U S A; 2010 Feb; 107(5):1966-70. PubMed ID: 20133841
[TBL] [Abstract][Full Text] [Related]
9. Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin.
Weil-Ktorza O; Rege N; Lansky S; Shalev DE; Shoham G; Weiss MA; Metanis N
Chemistry; 2019 Jun; 25(36):8513-8521. PubMed ID: 31012517
[TBL] [Abstract][Full Text] [Related]
10. Characteristic, activity and conformational studies of [A6-Ser, A11-Ser]-insulin.
Dai Y; Tang JG
Biochim Biophys Acta; 1996 Aug; 1296(1):63-8. PubMed ID: 8765230
[TBL] [Abstract][Full Text] [Related]
11. Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability.
Vinther TN; Pettersson I; Huus K; Schlein M; Steensgaard DB; Sørensen A; Jensen KJ; Kjeldsen T; Hubalek F
Protein Sci; 2015 May; 24(5):779-88. PubMed ID: 25627966
[TBL] [Abstract][Full Text] [Related]
12. Role of disulfide bonds in the structure and activity of human insulin.
Chang SG; Choi KD; Jang SH; Shin HC
Mol Cells; 2003 Dec; 16(3):323-30. PubMed ID: 14744022
[TBL] [Abstract][Full Text] [Related]
13. The road to the first, fully active and more stable human insulin variant with an additional disulfide bond.
Vinther TN; Kjeldsen TB; Jensen KJ; Hubálek F
J Pept Sci; 2015 Nov; 21(11):797-806. PubMed ID: 26382042
[TBL] [Abstract][Full Text] [Related]
14. A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers.
Hua QX; Jia W; Frank BH; Phillips NF; Weiss MA
Biochemistry; 2002 Dec; 41(50):14700-15. PubMed ID: 12475219
[TBL] [Abstract][Full Text] [Related]
15. Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity.
Hossain MA; Rosengren KJ; Zhang S; Bathgate RA; Tregear GW; van Lierop BJ; Robinson AJ; Wade JD
Org Biomol Chem; 2009 Apr; 7(8):1547-53. PubMed ID: 19343240
[TBL] [Abstract][Full Text] [Related]
16. pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity.
Kohn WD; Micanovic R; Myers SL; Vick AM; Kahl SD; Zhang L; Strifler BA; Li S; Shang J; Beals JM; Mayer JP; DiMarchi RD
Peptides; 2007 Apr; 28(4):935-48. PubMed ID: 17328992
[TBL] [Abstract][Full Text] [Related]
17. Receptor-isoform-selective insulin analogues give tissue-preferential effects.
Vienberg SG; Bouman SD; Sørensen H; Stidsen CE; Kjeldsen T; Glendorf T; Sørensen AR; Olsen GS; Andersen B; Nishimura E
Biochem J; 2011 Dec; 440(3):301-8. PubMed ID: 21851336
[TBL] [Abstract][Full Text] [Related]
18. Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability.
Hossain MA; Haugaard-Kedström LM; Rosengren KJ; Bathgate RA; Wade JD
Org Biomol Chem; 2015 Nov; 13(44):10895-903. PubMed ID: 26368576
[TBL] [Abstract][Full Text] [Related]
19. Beyond amino acid sequence: disulfide bonds and the origins of the extreme amyloidogenic properties of insulin's H-fragment.
Dec R; Koliński M; Dzwolak W
FEBS J; 2019 Aug; 286(16):3194-3205. PubMed ID: 30980592
[TBL] [Abstract][Full Text] [Related]
20. Flexibility exists in the region of [A6-A11, A7-B7] disulfide bonds during insulin precursor folding.
Liu Y; Wang ZH; Tang JG
J Biochem; 2004 Jan; 135(1):1-6. PubMed ID: 14999003
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
