These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

118 related articles for article (PubMed ID: 29903660)

  • 1. Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy.
    Nishiura Y; Matsumura A; Kobayashi N; Shimazaki A; Sakamoto S; Kitade N; Tonomura Y; Ino A; Okuno T
    Bioorg Med Chem Lett; 2018 Aug; 28(14):2498-2503. PubMed ID: 29903660
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways.
    Takagi H; Tanimoto K; Shimazaki A; Tonomura Y; Momosaki S; Sakamoto S; Abe K; Notoya M; Yukioka H
    J Pharmacol Exp Ther; 2020 Mar; 372(3):256-263. PubMed ID: 31900320
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
    Clark RF; Zhang T; Xin Z; Liu G; Wang Y; Hansen TM; Wang X; Wang R; Zhang X; Frevert EU; Camp HS; Beutel BA; Sham HL; Gu YG
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6078-81. PubMed ID: 16973360
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.
    Okazaki S; Noguchi-Yachide T; Sakai T; Ishikawa M; Makishima M; Hashimoto Y; Yamaguchi T
    Bioorg Med Chem; 2016 Nov; 24(21):5258-5269. PubMed ID: 27591006
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.
    Bourbeau MP; Siegmund A; Allen JG; Shu H; Fotsch C; Bartberger MD; Kim KW; Komorowski R; Graham M; Busby J; Wang M; Meyer J; Xu Y; Salyers K; Fielden M; Véniant MM; Gu W
    J Med Chem; 2013 Dec; 56(24):10132-41. PubMed ID: 24294923
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.
    Clark RF; Zhang T; Wang X; Wang R; Zhang X; Camp HS; Beutel BA; Sham HL; Gu YG
    Bioorg Med Chem Lett; 2007 Apr; 17(7):1961-5. PubMed ID: 17267221
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Acetyl-CoA carboxylase 2 inhibition reduces skeletal muscle bioactive lipid content and attenuates progression of type 2 diabetes in Zucker diabetic fatty rats.
    Takagi H; Ikehara T; Hashimoto K; Tanimoto K; Shimazaki A; Kashiwagi Y; Sakamoto S; Yukioka H
    Eur J Pharmacol; 2021 Nov; 910():174451. PubMed ID: 34454928
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors.
    Mizojiri R; Tomita D; Sasaki M; Satoh Y; Yamamoto Y; Sumi H; Maezaki H
    Bioorg Med Chem; 2021 Apr; 35():116056. PubMed ID: 33607488
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
    Haque TS; Liang N; Golla R; Seethala R; Ma Z; Ewing WR; Cooper CB; Pelleymounter MA; Poss MA; Cheng D
    Bioorg Med Chem Lett; 2009 Oct; 19(20):5872-6. PubMed ID: 19740659
    [TBL] [Abstract][Full Text] [Related]  

  • 10. WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice.
    Gao YS; Qian MY; Wei QQ; Duan XB; Wang SL; Hu HY; Liu J; Pan CY; Zhang SQ; Qi LW; Zhou JP; Zhang HB; Wang LR
    Acta Pharmacol Sin; 2020 Mar; 41(3):336-347. PubMed ID: 31645659
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
    Bengtsson C; Blaho S; Saitton DB; Brickmann K; Broddefalk J; Davidsson O; Drmota T; Folmer R; Hallberg K; Hallén S; Hovland R; Isin E; Johannesson P; Kull B; Larsson LO; Löfgren L; Nilsson KE; Noeske T; Oakes N; Plowright AT; Schnecke V; Ståhlberg P; Sörme P; Wan H; Wellner E; Oster L
    Bioorg Med Chem; 2011 May; 19(10):3039-53. PubMed ID: 21515056
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
    Yamashita T; Kamata M; Endo S; Yamamoto M; Kakegawa K; Watanabe H; Miwa K; Yamano T; Funata M; Sakamoto J; Tani A; Mol CD; Zou H; Dougan DR; Sang B; Snell G; Fukatsu K
    Bioorg Med Chem Lett; 2011 Nov; 21(21):6314-8. PubMed ID: 21944854
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors.
    Wei Q; Mei L; Yang Y; Ma H; Chen H; Zhang H; Zhou J
    Bioorg Med Chem; 2018 Aug; 26(14):3866-3874. PubMed ID: 30049586
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.
    Mizojiri R; Asano M; Tomita D; Banno H; Nii N; Sasaki M; Sumi H; Satoh Y; Yamamoto Y; Moriya T; Satomi Y; Maezaki H
    J Med Chem; 2018 Feb; 61(3):1098-1117. PubMed ID: 29232514
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
    Kung DW; Griffith DA; Esler WP; Vajdos FF; Mathiowetz AM; Doran SD; Amor PA; Bagley SW; Banks T; Cabral S; Ford K; Garcia-Irizarry CN; Landis MS; Loomis K; McPherson K; Niosi M; Rockwell KL; Rose C; Smith AC; Southers JA; Tapley S; Tu M; Valentine JJ
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5352-6. PubMed ID: 26411795
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.
    Chonan T; Tanaka H; Yamamoto D; Yashiro M; Oi T; Wakasugi D; Ohoka-Sugita A; Io F; Koretsune H; Hiratate A
    Bioorg Med Chem Lett; 2010 Jul; 20(13):3965-8. PubMed ID: 20537533
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
    Corbett JW; Freeman-Cook KD; Elliott R; Vajdos F; Rajamohan F; Kohls D; Marr E; Zhang H; Tong L; Tu M; Murdande S; Doran SD; Houser JA; Song W; Jones CJ; Coffey SB; Buzon L; Minich ML; Dirico KJ; Tapley S; McPherson RK; Sugarman E; Harwood HJ; Esler W
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2383-8. PubMed ID: 20219367
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
    Xu X; Weitzberg M; Keyes RF; Li Q; Wang R; Wang X; Zhang X; Frevert EU; Camp HS; Beutel BA; Sham HL; Gu YG
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1803-7. PubMed ID: 17234407
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
    Bagley SW; Southers JA; Cabral S; Rose CR; Bernhardson DJ; Edmonds DJ; Polivkova J; Yang X; Kung DW; Griffith DA; Bader SJ
    J Org Chem; 2012 Feb; 77(3):1497-506. PubMed ID: 22239115
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors.
    Huang T; Sun J; Wang Q; Gao J; Liu Y
    Molecules; 2015 Sep; 20(9):16221-34. PubMed ID: 26370948
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.