124 related articles for article (PubMed ID: 29903660)
1. Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy.
Nishiura Y; Matsumura A; Kobayashi N; Shimazaki A; Sakamoto S; Kitade N; Tonomura Y; Ino A; Okuno T
Bioorg Med Chem Lett; 2018 Aug; 28(14):2498-2503. PubMed ID: 29903660
[TBL] [Abstract][Full Text] [Related]
2. A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways.
Takagi H; Tanimoto K; Shimazaki A; Tonomura Y; Momosaki S; Sakamoto S; Abe K; Notoya M; Yukioka H
J Pharmacol Exp Ther; 2020 Mar; 372(3):256-263. PubMed ID: 31900320
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Clark RF; Zhang T; Xin Z; Liu G; Wang Y; Hansen TM; Wang X; Wang R; Zhang X; Frevert EU; Camp HS; Beutel BA; Sham HL; Gu YG
Bioorg Med Chem Lett; 2006 Dec; 16(23):6078-81. PubMed ID: 16973360
[TBL] [Abstract][Full Text] [Related]
4. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.
Okazaki S; Noguchi-Yachide T; Sakai T; Ishikawa M; Makishima M; Hashimoto Y; Yamaguchi T
Bioorg Med Chem; 2016 Nov; 24(21):5258-5269. PubMed ID: 27591006
[TBL] [Abstract][Full Text] [Related]
5. Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.
Bourbeau MP; Siegmund A; Allen JG; Shu H; Fotsch C; Bartberger MD; Kim KW; Komorowski R; Graham M; Busby J; Wang M; Meyer J; Xu Y; Salyers K; Fielden M; Véniant MM; Gu W
J Med Chem; 2013 Dec; 56(24):10132-41. PubMed ID: 24294923
[TBL] [Abstract][Full Text] [Related]
6. Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.
Clark RF; Zhang T; Wang X; Wang R; Zhang X; Camp HS; Beutel BA; Sham HL; Gu YG
Bioorg Med Chem Lett; 2007 Apr; 17(7):1961-5. PubMed ID: 17267221
[TBL] [Abstract][Full Text] [Related]
7. Acetyl-CoA carboxylase 2 inhibition reduces skeletal muscle bioactive lipid content and attenuates progression of type 2 diabetes in Zucker diabetic fatty rats.
Takagi H; Ikehara T; Hashimoto K; Tanimoto K; Shimazaki A; Kashiwagi Y; Sakamoto S; Yukioka H
Eur J Pharmacol; 2021 Nov; 910():174451. PubMed ID: 34454928
[TBL] [Abstract][Full Text] [Related]
8. Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors.
Mizojiri R; Tomita D; Sasaki M; Satoh Y; Yamamoto Y; Sumi H; Maezaki H
Bioorg Med Chem; 2021 Apr; 35():116056. PubMed ID: 33607488
[TBL] [Abstract][Full Text] [Related]
9. Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
Haque TS; Liang N; Golla R; Seethala R; Ma Z; Ewing WR; Cooper CB; Pelleymounter MA; Poss MA; Cheng D
Bioorg Med Chem Lett; 2009 Oct; 19(20):5872-6. PubMed ID: 19740659
[TBL] [Abstract][Full Text] [Related]
10. WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice.
Gao YS; Qian MY; Wei QQ; Duan XB; Wang SL; Hu HY; Liu J; Pan CY; Zhang SQ; Qi LW; Zhou JP; Zhang HB; Wang LR
Acta Pharmacol Sin; 2020 Mar; 41(3):336-347. PubMed ID: 31645659
[TBL] [Abstract][Full Text] [Related]
11. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bengtsson C; Blaho S; Saitton DB; Brickmann K; Broddefalk J; Davidsson O; Drmota T; Folmer R; Hallberg K; Hallén S; Hovland R; Isin E; Johannesson P; Kull B; Larsson LO; Löfgren L; Nilsson KE; Noeske T; Oakes N; Plowright AT; Schnecke V; Ståhlberg P; Sörme P; Wan H; Wellner E; Oster L
Bioorg Med Chem; 2011 May; 19(10):3039-53. PubMed ID: 21515056
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
Yamashita T; Kamata M; Endo S; Yamamoto M; Kakegawa K; Watanabe H; Miwa K; Yamano T; Funata M; Sakamoto J; Tani A; Mol CD; Zou H; Dougan DR; Sang B; Snell G; Fukatsu K
Bioorg Med Chem Lett; 2011 Nov; 21(21):6314-8. PubMed ID: 21944854
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors.
Wei Q; Mei L; Yang Y; Ma H; Chen H; Zhang H; Zhou J
Bioorg Med Chem; 2018 Aug; 26(14):3866-3874. PubMed ID: 30049586
[TBL] [Abstract][Full Text] [Related]
14. Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.
Mizojiri R; Asano M; Tomita D; Banno H; Nii N; Sasaki M; Sumi H; Satoh Y; Yamamoto Y; Moriya T; Satomi Y; Maezaki H
J Med Chem; 2018 Feb; 61(3):1098-1117. PubMed ID: 29232514
[TBL] [Abstract][Full Text] [Related]
15. Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Kung DW; Griffith DA; Esler WP; Vajdos FF; Mathiowetz AM; Doran SD; Amor PA; Bagley SW; Banks T; Cabral S; Ford K; Garcia-Irizarry CN; Landis MS; Loomis K; McPherson K; Niosi M; Rockwell KL; Rose C; Smith AC; Southers JA; Tapley S; Tu M; Valentine JJ
Bioorg Med Chem Lett; 2015 Nov; 25(22):5352-6. PubMed ID: 26411795
[TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.
Chonan T; Tanaka H; Yamamoto D; Yashiro M; Oi T; Wakasugi D; Ohoka-Sugita A; Io F; Koretsune H; Hiratate A
Bioorg Med Chem Lett; 2010 Jul; 20(13):3965-8. PubMed ID: 20537533
[TBL] [Abstract][Full Text] [Related]
17. Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Corbett JW; Freeman-Cook KD; Elliott R; Vajdos F; Rajamohan F; Kohls D; Marr E; Zhang H; Tong L; Tu M; Murdande S; Doran SD; Houser JA; Song W; Jones CJ; Coffey SB; Buzon L; Minich ML; Dirico KJ; Tapley S; McPherson RK; Sugarman E; Harwood HJ; Esler W
Bioorg Med Chem Lett; 2010 Apr; 20(7):2383-8. PubMed ID: 20219367
[TBL] [Abstract][Full Text] [Related]
18. The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
Xu X; Weitzberg M; Keyes RF; Li Q; Wang R; Wang X; Zhang X; Frevert EU; Camp HS; Beutel BA; Sham HL; Gu YG
Bioorg Med Chem Lett; 2007 Mar; 17(6):1803-7. PubMed ID: 17234407
[TBL] [Abstract][Full Text] [Related]
19. Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
Bagley SW; Southers JA; Cabral S; Rose CR; Bernhardson DJ; Edmonds DJ; Polivkova J; Yang X; Kung DW; Griffith DA; Bader SJ
J Org Chem; 2012 Feb; 77(3):1497-506. PubMed ID: 22239115
[TBL] [Abstract][Full Text] [Related]
20. Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors.
Huang T; Sun J; Wang Q; Gao J; Liu Y
Molecules; 2015 Sep; 20(9):16221-34. PubMed ID: 26370948
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
